Motif ID: Epas1_Bcl3

Z-value: 2.017

Transcription factors associated with Epas1_Bcl3:

Gene SymbolEntrez IDGene Name
Bcl3 ENSMUSG00000053175.10 Bcl3
Epas1 ENSMUSG00000024140.9 Epas1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Epas1mm10_v2_chr17_+_86753900_867539140.341.0e-02Click!


Activity profile for motif Epas1_Bcl3.

activity profile for motif Epas1_Bcl3


Sorted Z-values histogram for motif Epas1_Bcl3

Sorted Z-values for motif Epas1_Bcl3



Network of associatons between targets according to the STRING database.



First level regulatory network of Epas1_Bcl3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_48932368 34.778 ENSMUST00000046254.2
 Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
chr14_-_60177482 25.076 ENSMUST00000140924.1
 Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr8_-_48555846 24.737 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr2_+_169632996 22.998 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr19_+_8664005 22.163 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr2_-_113217051 22.050 ENSMUST00000080673.5
 Ryr3
ryanodine receptor 3
chr4_+_123183722 20.356 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr6_+_65671590 19.651 ENSMUST00000054351.4
 Ndnf
neuron-derived neurotrophic factor
chr9_-_29963112 19.615 ENSMUST00000075069.4
 Ntm
neurotrimin
chr12_-_67221221 19.522 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr5_-_128953303 19.470 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr4_+_48045144 18.686 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr7_-_119184374 17.118 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr19_+_23758819 16.409 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr12_+_61523889 16.248 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr1_+_75507077 15.700 ENSMUST00000037330.4
 Inha
inhibin alpha
chr12_-_14152038 15.408 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr17_+_86167777 15.243 ENSMUST00000097275.2
 Prkce
protein kinase C, epsilon
chr7_-_27446599 14.460 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr5_+_27261916 14.283 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 40.8 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
3.3 26.4 GO:0097264 self proteolysis(GO:0097264)
1.5 26.1 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.5 25.0 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
4.9 24.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
4.1 24.6 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.3 23.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 23.4 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
1.1 22.0 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.5 21.0 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
2.3 20.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 19.4 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
6.2 18.7 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 18.7 GO:0010977 negative regulation of neuron projection development(GO:0010977)
2.7 16.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.3 15.6 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.4 15.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
3.8 15.2 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
1.6 14.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.4 14.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 39.9 GO:0016021 integral component of membrane(GO:0016021)
0.1 37.8 GO:0045211 postsynaptic membrane(GO:0045211)
1.6 34.3 GO:0032279 asymmetric synapse(GO:0032279)
0.3 26.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 25.4 GO:0000139 Golgi membrane(GO:0000139)
0.1 25.2 GO:0043005 neuron projection(GO:0043005)
8.2 24.6 GO:0043512 inhibin A complex(GO:0043512)
0.2 24.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 23.1 GO:0005802 trans-Golgi network(GO:0005802)
4.4 22.0 GO:0030314 junctional membrane complex(GO:0030314)
0.1 22.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 20.0 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 17.5 GO:0005768 endosome(GO:0005768)
0.1 16.5 GO:0043197 dendritic spine(GO:0043197)
1.0 16.2 GO:0031143 pseudopodium(GO:0031143)
0.4 15.4 GO:0097440 apical dendrite(GO:0097440)
0.6 14.7 GO:0031430 M band(GO:0031430)
2.4 14.5 GO:0008091 spectrin(GO:0008091)
0.3 12.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 11.9 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 40.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.6 36.1 GO:0030507 spectrin binding(GO:0030507)
0.5 29.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.7 28.6 GO:0005246 calcium channel regulator activity(GO:0005246)
4.9 24.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
2.7 24.6 GO:0034711 inhibin binding(GO:0034711)
0.4 23.4 GO:0015459 potassium channel regulator activity(GO:0015459)
7.3 22.0 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 19.6 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.5 18.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.5 18.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.9 17.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.5 17.0 GO:0043015 gamma-tubulin binding(GO:0043015)
5.4 16.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 15.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 15.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
3.8 15.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
1.2 13.6 GO:0004017 adenylate kinase activity(GO:0004017)
2.2 13.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
2.0 11.8 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 36.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.6 23.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.6 18.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.3 13.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 13.0 PID_LKB1_PATHWAY LKB1 signaling events
0.3 11.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 8.2 PID_ALK1_PATHWAY ALK1 signaling events
0.2 8.2 PID_SHP2_PATHWAY SHP2 signaling
0.3 8.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 7.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 6.9 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 6.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 6.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 5.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 4.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 4.3 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.2 3.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 2.2 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.0 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 40.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.9 29.5 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
2.0 26.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.9 24.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
6.2 24.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.6 18.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.5 17.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.7 16.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.8 14.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.4 14.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 13.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 11.4 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.2 10.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.5 10.1 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.7 8.5 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.7 7.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 7.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.4 7.1 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 6.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.6 6.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors