Motif ID: Erg

Z-value: 1.043


Transcription factors associated with Erg:

Gene SymbolEntrez IDGene Name
Erg ENSMUSG00000040732.12 Erg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ergmm10_v2_chr16_-_95459245_954593840.412.0e-03Click!


Activity profile for motif Erg.

activity profile for motif Erg


Sorted Z-values histogram for motif Erg

Sorted Z-values for motif Erg



Network of associatons between targets according to the STRING database.



First level regulatory network of Erg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 5.969 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr1_-_56969827 5.246 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 5.194 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56972437 5.004 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr9_-_54661870 4.840 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr13_-_41487306 4.805 ENSMUST00000021794.6
 Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr5_+_75152274 4.725 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr14_-_25769033 4.669 ENSMUST00000069180.7
 Zcchc24
zinc finger, CCHC domain containing 24
chr4_+_144893077 4.470 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr16_-_38713235 4.446 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr11_-_55419898 4.170 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr11_-_101785252 3.906 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr12_+_75308308 3.814 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr4_+_144893127 3.792 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_68869563 3.566 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr9_-_54661666 3.508 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr18_+_5593566 3.250 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr10_-_58675631 3.123 ENSMUST00000003312.4
 Edar
ectodysplasin-A receptor
chr16_+_43363855 3.050 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chrX_+_110814390 2.972 ENSMUST00000078229.3
 Pou3f4
POU domain, class 3, transcription factor 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 226 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 15.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.3 14.2 GO:0042572 retinol metabolic process(GO:0042572)
0.2 8.0 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 5.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 5.7 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 5.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.6 4.7 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.3 4.2 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 4.1 GO:0070207 protein homotrimerization(GO:0070207)
0.4 3.8 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.4 3.8 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.6 3.7 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.2 3.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 3.6 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.3 3.2 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.3 3.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.3 3.0 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.6 2.8 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.5 2.7 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 2.7 GO:0008654 phospholipid biosynthetic process(GO:0008654)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 24.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 7.5 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.1 6.4 GO:0005902 microvillus(GO:0005902)
0.0 5.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 4.7 GO:0030131 clathrin adaptor complex(GO:0030131)
1.1 4.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.0 4.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 4.1 GO:0000922 spindle pole(GO:0000922)
0.1 3.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.1 GO:0031225 anchored component of membrane(GO:0031225)
0.5 2.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.9 2.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 2.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 2.6 GO:0001739 sex chromatin(GO:0001739)
0.2 2.6 GO:0032426 stereocilium tip(GO:0032426)
0.0 2.6 GO:0043235 receptor complex(GO:0043235)
0.2 2.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.1 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 21.9 GO:0003682 chromatin binding(GO:0003682)
2.0 14.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.8 8.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 7.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 7.6 GO:0005518 collagen binding(GO:0005518)
0.1 7.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.3 6.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 5.9 GO:0017124 SH3 domain binding(GO:0017124)
0.2 3.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 3.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 3.6 GO:0051015 actin filament binding(GO:0051015)
0.2 3.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 3.2 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.3 2.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.9 2.8 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.4 2.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 2.7 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 2.6 GO:0030274 LIM domain binding(GO:0030274)
0.2 2.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 9.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 7.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 4.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.3 PID_FGF_PATHWAY FGF signaling pathway
0.1 3.0 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.5 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 2.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.3 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 2.1 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.1 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.8 PID_VEGFR1_PATHWAY VEGFR1 specific signals

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 6.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 6.1 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.3 4.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 3.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 3.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 3.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 2.8 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 2.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 2.3 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.3 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.2 2.2 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 2.1 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 2.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.6 1.8 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 1.7 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 1.6 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL