Motif ID: Esr1

Z-value: 0.874


Transcription factors associated with Esr1:

Gene SymbolEntrez IDGene Name
Esr1 ENSMUSG00000019768.10 Esr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr1mm10_v2_chr10_+_4611971_46120210.085.6e-01Click!


Activity profile for motif Esr1.

activity profile for motif Esr1


Sorted Z-values histogram for motif Esr1

Sorted Z-values for motif Esr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_66860458 2.873 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr16_-_76373827 2.451 ENSMUST00000121927.1
 Nrip1
nuclear receptor interacting protein 1
chr4_+_152199805 2.259 ENSMUST00000105652.2
 Acot7
acyl-CoA thioesterase 7
chr18_-_38211957 2.249 ENSMUST00000159405.1
ENSMUST00000160721.1
 Pcdh1

protocadherin 1

chr4_-_141598206 2.190 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr1_+_34579693 2.176 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr3_+_117575268 2.142 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr1_-_87573825 2.138 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor
chr2_-_166155272 2.096 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr12_+_109747903 2.045 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr13_+_31806627 2.032 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr10_-_125308809 1.923 ENSMUST00000105257.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr19_-_57182293 1.868 ENSMUST00000133369.1
 Ablim1
actin-binding LIM protein 1
chr5_-_77408034 1.850 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7

chr14_+_57999305 1.746 ENSMUST00000180534.1
 3110083C13Rik
RIKEN cDNA 3110083C13 gene
chr2_+_122147680 1.721 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr5_-_143909782 1.718 ENSMUST00000031613.4
ENSMUST00000100483.2
 Aimp2

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

chr8_-_68735058 1.678 ENSMUST00000136060.1
ENSMUST00000130214.1
ENSMUST00000078350.6
 Csgalnact1


chondroitin sulfate N-acetylgalactosaminyltransferase 1


chr5_+_127632238 1.566 ENSMUST00000118139.1
 Glt1d1
glycosyltransferase 1 domain containing 1
chr15_-_93595877 1.559 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.2 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.6 2.9 GO:0002024 diet induced thermogenesis(GO:0002024)
0.5 2.7 GO:0032439 endosome localization(GO:0032439)
0.1 2.7 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.8 2.5 GO:0001543 ovarian follicle rupture(GO:0001543)
0.8 2.4 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.6 2.4 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.0 2.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.5 2.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.5 2.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 2.1 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.7 2.0 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.4 2.0 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.5 1.9 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.2 1.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.6 1.8 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.4 1.8 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.6 1.7 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)
0.4 1.7 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 1.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.5 2.7 GO:0045179 apical cortex(GO:0045179)
0.5 2.5 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.4 2.4 GO:0061689 tricellular tight junction(GO:0061689)
0.2 2.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.3 2.3 GO:0061574 ASAP complex(GO:0061574)
0.1 2.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.3 GO:0005911 cell-cell junction(GO:0005911)
0.2 1.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.2 1.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 1.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 1.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 1.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 1.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 1.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 1.2 GO:0097452 GAIT complex(GO:0097452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 178 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 3.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 3.0 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
1.0 2.9 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 2.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.4 2.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 2.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.5 2.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 2.0 GO:0008301 DNA binding, bending(GO:0008301)
0.5 1.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 1.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.9 GO:0008201 heparin binding(GO:0008201)
0.0 1.8 GO:0050699 WW domain binding(GO:0050699)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.8 GO:0015485 cholesterol binding(GO:0015485)
0.4 1.7 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.2 1.7 GO:0048495 Roundabout binding(GO:0048495)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 3.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 2.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 1.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.6 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 1.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.4 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.3 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.2 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.9 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 2.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.3 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.2 2.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.0 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 2.0 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.8 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 1.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.7 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.6 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 1.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.5 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation