Motif ID: Esr2

Z-value: 1.714


Transcription factors associated with Esr2:

Gene SymbolEntrez IDGene Name
Esr2 ENSMUSG00000021055.7 Esr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr2mm10_v2_chr12_-_76177251_761772650.085.6e-01Click!


Activity profile for motif Esr2.

activity profile for motif Esr2


Sorted Z-values histogram for motif Esr2

Sorted Z-values for motif Esr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78499087 10.560 ENSMUST00000017488.4
 Vtn
vitronectin
chr2_-_25470031 9.825 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr18_+_20665250 9.261 ENSMUST00000075312.3
 Ttr
transthyretin
chr4_-_136892867 9.127 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr2_-_25469742 9.030 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr11_-_6065538 6.923 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr6_-_35308110 5.561 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr8_+_70501116 5.360 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr5_+_35056813 5.228 ENSMUST00000101298.2
ENSMUST00000114270.1
ENSMUST00000133381.1
 Dok7


docking protein 7


chr10_-_86732409 4.824 ENSMUST00000070435.4
 Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr15_-_66801577 4.773 ENSMUST00000168589.1
 Sla
src-like adaptor
chr2_-_131042682 4.770 ENSMUST00000028787.5
ENSMUST00000110239.1
ENSMUST00000110234.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr11_+_101246960 4.747 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr15_+_80287234 4.492 ENSMUST00000160424.1
 Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit
chr19_+_44992127 4.292 ENSMUST00000179305.1
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr4_-_46991842 4.288 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr19_+_8591254 4.281 ENSMUST00000010251.3
ENSMUST00000170817.1
 Slc22a8

solute carrier family 22 (organic anion transporter), member 8

chr4_+_128058962 4.276 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr13_+_38345716 4.257 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr5_-_113015473 4.230 ENSMUST00000065167.4
 Adrbk2
adrenergic receptor kinase, beta 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 823 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 18.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.2 11.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
3.5 10.6 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430)
0.3 10.6 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
1.2 9.9 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
1.9 9.6 GO:0070327 thyroid hormone transport(GO:0070327)
1.4 9.6 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.8 9.1 GO:0097421 liver regeneration(GO:0097421)
0.3 8.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.8 8.6 GO:0043589 skin morphogenesis(GO:0043589)
1.3 7.6 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.3 7.0 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
2.3 6.9 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.6 6.8 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.4 6.8 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
1.1 6.6 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
1.0 6.3 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.7 6.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.8 6.2 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.5 6.0 GO:0008272 sulfate transport(GO:0008272)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 303 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 38.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 36.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 24.3 GO:0005768 endosome(GO:0005768)
0.0 22.9 GO:0016021 integral component of membrane(GO:0016021)
0.2 16.8 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.3 14.5 GO:0034704 calcium channel complex(GO:0034704)
0.2 14.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 13.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 12.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
2.3 11.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 9.7 GO:0051233 spindle midzone(GO:0051233)
0.1 9.7 GO:0072562 blood microparticle(GO:0072562)
0.1 9.3 GO:0005884 actin filament(GO:0005884)
1.0 8.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
2.6 7.9 GO:0005584 collagen type I trimer(GO:0005584)
0.2 7.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 7.8 GO:0000139 Golgi membrane(GO:0000139)
0.2 7.5 GO:0097440 apical dendrite(GO:0097440)
0.5 7.2 GO:0043203 axon hillock(GO:0043203)
1.4 7.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 490 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.8 GO:0005096 GTPase activator activity(GO:0005096)
4.7 18.8 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.8 14.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.4 14.0 GO:0005158 insulin receptor binding(GO:0005158)
0.4 13.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 12.8 GO:0003779 actin binding(GO:0003779)
1.3 11.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.4 10.5 GO:0043274 phospholipase binding(GO:0043274)
0.6 10.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 10.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 9.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.4 8.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3 8.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.2 8.1 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 7.2 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
1.2 7.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 7.1 GO:0008565 protein transporter activity(GO:0008565)
0.2 7.0 GO:0030742 GTP-dependent protein binding(GO:0030742)
2.3 6.9 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
2.3 6.9 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 27.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 16.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 12.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.5 12.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 11.8 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.2 10.2 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.5 9.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 6.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 6.0 PID_ARF_3PATHWAY Arf1 pathway
0.1 5.6 PID_LKB1_PATHWAY LKB1 signaling events
0.3 5.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 5.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 5.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.2 4.5 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 4.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.2 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.1 4.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 3.7 PID_S1P_S1P2_PATHWAY S1P2 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 13.1 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 11.8 REACTOME_AMYLOIDS Genes involved in Amyloids
0.9 11.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 10.4 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.6 9.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.7 9.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 9.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
1.5 8.7 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 8.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 8.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 7.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 7.7 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 7.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 7.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 7.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.5 6.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 6.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 5.9 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 5.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 5.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression