Motif ID: Esrrb_Esrra

Z-value: 1.256

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrramm10_v2_chr19_-_6921753_6921803-0.143.2e-01Click!
Esrrbmm10_v2_chr12_+_86421628_864216620.066.6e-01Click!


Activity profile for motif Esrrb_Esrra.

activity profile for motif Esrrb_Esrra


Sorted Z-values histogram for motif Esrrb_Esrra

Sorted Z-values for motif Esrrb_Esrra



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 14.083 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr11_+_7063423 11.663 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr19_-_57314896 8.690 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr3_-_54915867 8.675 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr2_+_121357714 8.343 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr15_-_79804717 7.407 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chrX_-_72656135 7.407 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr4_+_13751297 7.306 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_-_167393826 7.179 ENSMUST00000028005.2
 Mgst3
microsomal glutathione S-transferase 3
chr2_+_121358591 7.124 ENSMUST00000000317.6
ENSMUST00000129130.1
 Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr1_-_84696182 7.035 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chr15_+_84669565 6.862 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr5_-_110343009 6.541 ENSMUST00000058016.9
ENSMUST00000112478.3
 P2rx2

purinergic receptor P2X, ligand-gated ion channel, 2

chr7_-_74554474 6.482 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr7_-_141429351 6.448 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
 Cend1


cell cycle exit and neuronal differentiation 1


chr6_+_38663061 6.405 ENSMUST00000114874.3
 Clec2l
C-type lectin domain family 2, member L
chr8_+_124793061 6.337 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr8_+_124793013 6.299 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr11_+_98741805 5.912 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha
chr7_-_141429433 5.683 ENSMUST00000124444.1
 Cend1
cell cycle exit and neuronal differentiation 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 262 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.1 GO:0032091 negative regulation of protein binding(GO:0032091)
0.3 12.7 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.5 12.6 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.2 12.2 GO:0071277 cellular response to calcium ion(GO:0071277)
4.0 12.1 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.8 11.7 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.9 11.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
1.2 11.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 9.4 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.8 8.3 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.3 7.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 7.9 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.4 7.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.5 7.0 GO:0007220 Notch receptor processing(GO:0007220)
0.8 6.9 GO:0038203 TORC2 signaling(GO:0038203)
0.1 6.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.7 6.5 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
2.0 5.9 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
1.1 5.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.4 5.5 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 18.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 18.3 GO:0043204 perikaryon(GO:0043204)
0.0 17.1 GO:0030054 cell junction(GO:0030054)
0.8 12.3 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.2 11.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.6 11.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 10.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 8.1 GO:0009986 cell surface(GO:0009986)
0.8 7.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.5 6.9 GO:0031932 TORC2 complex(GO:0031932)
0.8 6.8 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.5 6.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.4 6.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 6.6 GO:0005604 basement membrane(GO:0005604)
0.6 6.4 GO:0032426 stereocilium tip(GO:0032426)
0.1 6.2 GO:0016363 nuclear matrix(GO:0016363)
0.7 5.9 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 5.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 5.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 5.3 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
4.2 16.7 GO:0004111 creatine kinase activity(GO:0004111)
0.8 13.1 GO:0004890 GABA-A receptor activity(GO:0004890)
1.9 11.7 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.4 11.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.5 10.8 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.5 10.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 10.4 GO:0030246 carbohydrate binding(GO:0030246)
0.6 8.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.9 7.4 GO:0001847 opsonin receptor activity(GO:0001847)
0.3 7.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.8 7.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 6.9 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 6.5 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) mercury ion binding(GO:0045340)
0.1 6.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 6.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.3 6.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.7 6.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
2.0 5.9 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.3 5.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.7 11.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 9.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 7.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 7.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 6.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 5.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.7 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 4.1 PID_MTOR_4PATHWAY mTOR signaling pathway
0.3 4.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 2.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.2 PID_ARF_3PATHWAY Arf1 pathway
0.2 2.0 PID_ALK2_PATHWAY ALK2 signaling events
0.1 1.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.8 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 1.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.3 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.9 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 22.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.6 20.1 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
1.2 18.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 12.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
1.0 11.7 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.6 11.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
1.3 10.8 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.3 8.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 7.2 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 7.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.5 6.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 6.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 6.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 5.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.7 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.6 4.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 4.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 4.0 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.5 3.8 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 3.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane