Motif ID: Ets1

Z-value: 0.777


Transcription factors associated with Ets1:

Gene SymbolEntrez IDGene Name
Ets1 ENSMUSG00000032035.9 Ets1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets1mm10_v2_chr9_+_32696005_32696121-0.384.0e-03Click!


Activity profile for motif Ets1.

activity profile for motif Ets1


Sorted Z-values histogram for motif Ets1

Sorted Z-values for motif Ets1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 4.631 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr11_-_20112876 3.456 ENSMUST00000000137.7
 Actr2
ARP2 actin-related protein 2
chr6_-_115994953 2.884 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr11_-_76509419 2.613 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr14_-_19977249 2.481 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr11_+_87592145 2.343 ENSMUST00000103179.3
ENSMUST00000092802.5
ENSMUST00000146871.1
 Mtmr4


myotubularin related protein 4


chr6_+_5725639 2.321 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr7_+_62348277 2.285 ENSMUST00000038775.4
 Ndn
necdin
chr14_-_19977040 2.258 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_19977151 2.195 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr9_+_110476985 2.193 ENSMUST00000084948.4
ENSMUST00000061155.6
ENSMUST00000140686.1
ENSMUST00000084952.5
 Kif9



kinesin family member 9



chr10_-_6980376 2.182 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr6_+_5725812 2.112 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr3_+_98382438 2.035 ENSMUST00000056096.8
 Zfp697
zinc finger protein 697
chr11_-_105944412 1.982 ENSMUST00000019734.4
ENSMUST00000184269.1
ENSMUST00000150563.1
 Cyb561


cytochrome b-561


chr3_+_98382538 1.948 ENSMUST00000178372.1
 Zfp697
zinc finger protein 697
chr12_+_112760652 1.936 ENSMUST00000063888.3
 Pld4
phospholipase D family, member 4
chr3_+_82358056 1.738 ENSMUST00000091014.4
 Map9
microtubule-associated protein 9
chr18_+_23803962 1.737 ENSMUST00000025127.3
 Mapre2
microtubule-associated protein, RP/EB family, member 2
chr3_-_89245159 1.721 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 457 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.4 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 4.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.2 3.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.2 3.5 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.2 3.3 GO:0015693 magnesium ion transport(GO:0015693)
0.1 3.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.8 3.2 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.1 3.2 GO:0018279 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.3 3.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 3.1 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.1 3.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.6 2.9 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.5 2.9 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 2.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 2.7 GO:0017085 response to insecticide(GO:0017085)
0.5 2.6 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.3 2.5 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.2 2.5 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.1 2.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.8 2.4 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 217 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.1 GO:0030018 Z disc(GO:0030018)
0.1 4.8 GO:0002102 podosome(GO:0002102)
1.1 4.6 GO:1990769 proximal neuron projection(GO:1990769)
1.5 4.4 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.2 3.8 GO:0030008 TRAPP complex(GO:0030008)
0.1 3.8 GO:0031430 M band(GO:0031430)
0.2 3.7 GO:0000145 exocyst(GO:0000145)
0.0 3.7 GO:0031225 anchored component of membrane(GO:0031225)
0.4 3.5 GO:0030478 actin cap(GO:0030478)
0.1 3.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 3.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 3.2 GO:0000242 pericentriolar material(GO:0000242)
0.5 3.0 GO:0097443 sorting endosome(GO:0097443)
0.0 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 2.5 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306)
0.2 2.3 GO:0031209 SCAR complex(GO:0031209)
0.1 2.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 2.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 2.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 286 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0008017 microtubule binding(GO:0008017)
0.1 7.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.4 7.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 5.5 GO:0008565 protein transporter activity(GO:0008565)
0.1 4.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 4.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 3.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 3.9 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 3.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.8 GO:0050699 WW domain binding(GO:0050699)
0.1 3.6 GO:0019003 GDP binding(GO:0019003)
0.2 3.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 3.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 3.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 3.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 3.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 3.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 3.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 3.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 2.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.5 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 7.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.5 6.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 4.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 3.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.3 PID_ARF_3PATHWAY Arf1 pathway
0.1 3.3 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.0 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.9 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 2.8 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 2.7 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.1 2.7 PID_INSULIN_PATHWAY Insulin Pathway
0.2 2.6 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 1.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.4 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.2 6.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 5.8 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.2 5.7 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 4.5 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 4.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.2 4.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 4.3 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 3.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 3.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 2.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.6 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 2.3 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 2.1 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.9 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.9 1.8 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS Genes involved in Host Interactions of HIV factors
0.0 1.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors