Motif ID: Ets2

Z-value: 1.120


Transcription factors associated with Ets2:

Gene SymbolEntrez IDGene Name
Ets2 ENSMUSG00000022895.8 Ets2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets2mm10_v2_chr16_+_95702044_957020940.821.2e-14Click!


Activity profile for motif Ets2.

activity profile for motif Ets2


Sorted Z-values histogram for motif Ets2

Sorted Z-values for motif Ets2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 17.293 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr6_+_5725812 14.698 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr15_-_66969616 10.116 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr9_-_29411736 9.748 ENSMUST00000115236.1
 Ntm
neurotrimin
chr1_-_56969864 9.230 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr5_-_44799643 8.924 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr1_-_56969827 8.899 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr17_+_3397189 8.845 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr7_-_4546567 7.439 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr4_+_128058962 6.955 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr11_-_67922136 6.860 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr10_+_85386813 6.707 ENSMUST00000105307.1
ENSMUST00000020231.3
 Btbd11

BTB (POZ) domain containing 11

chr17_-_68004075 6.609 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr2_-_5714490 6.060 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr13_+_109632760 5.291 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr3_-_87768932 5.279 ENSMUST00000173184.1
ENSMUST00000172621.1
ENSMUST00000174759.1
ENSMUST00000172590.1
ENSMUST00000079083.5
 Pear1




platelet endothelial aggregation receptor 1




chr9_-_110476637 4.976 ENSMUST00000111934.1
ENSMUST00000068025.6
 Klhl18

kelch-like 18

chr7_+_30413744 4.927 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr19_-_57360668 4.900 ENSMUST00000181921.1
 B230217O12Rik
RIKEN cDNA B230217O12 gene
chr11_+_70647258 4.840 ENSMUST00000037534.7
 Rnf167
ring finger protein 167

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 32.0 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 32.0 GO:0007266 Rho protein signal transduction(GO:0007266)
1.1 18.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.3 11.8 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.9 10.1 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
1.0 8.8 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.5 7.7 GO:0036296 cellular response to increased oxygen levels(GO:0036295) response to increased oxygen levels(GO:0036296)
0.2 7.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 6.7 GO:0060395 SMAD protein signal transduction(GO:0060395)
1.7 6.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 6.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.9 6.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
1.2 5.9 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.7 5.9 GO:0030259 lipid glycosylation(GO:0030259)
0.5 5.8 GO:0002281 macrophage activation involved in immune response(GO:0002281)
1.8 5.5 GO:0019085 early viral transcription(GO:0019085)
0.9 5.3 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.4 5.3 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 5.2 GO:0016579 protein deubiquitination(GO:0016579)
1.0 4.8 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.7 32.0 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.3 14.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.4 11.8 GO:0031430 M band(GO:0031430)
0.2 11.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 10.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 9.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 9.7 GO:0045211 postsynaptic membrane(GO:0045211)
1.0 8.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 8.0 GO:0000118 histone deacetylase complex(GO:0000118)
1.9 7.4 GO:1990769 proximal neuron projection(GO:1990769)
0.0 7.4 GO:0000139 Golgi membrane(GO:0000139)
0.1 6.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 6.2 GO:0005802 trans-Golgi network(GO:0005802)
1.0 5.9 GO:0097443 sorting endosome(GO:0097443)
0.3 5.4 GO:0032279 asymmetric synapse(GO:0032279)
0.1 5.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 5.0 GO:0000421 autophagosome membrane(GO:0000421)
0.8 4.8 GO:0000235 astral microtubule(GO:0000235)
0.7 4.8 GO:0071439 clathrin complex(GO:0071439)
0.2 4.8 GO:0001891 phagocytic cup(GO:0001891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 32.0 GO:0045504 dynein heavy chain binding(GO:0045504)
0.3 24.1 GO:0030276 clathrin binding(GO:0030276)
0.2 20.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 14.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 12.3 GO:0005096 GTPase activator activity(GO:0005096)
0.2 11.8 GO:0030507 spectrin binding(GO:0030507)
0.0 11.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 9.3 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 9.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.4 8.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 8.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 6.3 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 5.6 GO:0008432 JUN kinase binding(GO:0008432)
0.4 5.5 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 5.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.2 5.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 5.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 5.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 4.9 GO:0008013 beta-catenin binding(GO:0008013)
0.2 4.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 11.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 7.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 7.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 6.7 PID_INSULIN_PATHWAY Insulin Pathway
0.2 6.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 4.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 4.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 4.6 PID_ARF_3PATHWAY Arf1 pathway
0.2 4.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 4.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.3 PID_BCR_5PATHWAY BCR signaling pathway
0.1 3.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.3 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.1 2.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.8 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 2.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 2.7 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 2.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.2 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 33.8 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.6 12.2 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 11.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.5 10.3 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 9.8 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.6 8.7 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.4 8.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.5 6.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 6.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 6.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 5.5 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.3 5.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 5.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 4.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 4.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 3.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 3.3 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 3.1 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 2.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 2.7 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1