Motif ID: Etv1_Etv5_Gabpa

Z-value: 1.406

Transcription factors associated with Etv1_Etv5_Gabpa:

Gene SymbolEntrez IDGene Name
Etv1 ENSMUSG00000004151.10 Etv1
Etv5 ENSMUSG00000013089.9 Etv5
Gabpa ENSMUSG00000008976.10 Gabpa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv5mm10_v2_chr16_-_22439570_22439603-0.551.5e-05Click!
Gabpamm10_v2_chr16_+_84834901_84834941-0.104.7e-01Click!
Etv1mm10_v2_chr12_+_38783503_387835270.085.6e-01Click!


Activity profile for motif Etv1_Etv5_Gabpa.

activity profile for motif Etv1_Etv5_Gabpa


Sorted Z-values histogram for motif Etv1_Etv5_Gabpa

Sorted Z-values for motif Etv1_Etv5_Gabpa



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv1_Etv5_Gabpa

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_127042420 12.873 ENSMUST00000032915.6
 Kif22
kinesin family member 22
chr2_+_5845243 10.487 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr11_-_94653964 10.357 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr16_-_22161450 10.309 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr2_+_118814237 10.082 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr2_+_152847961 10.000 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
 Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)


chr2_+_152847993 9.483 ENSMUST00000028969.8
 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr19_+_6084983 9.416 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr2_+_118814195 9.357 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr2_+_105682463 9.240 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr4_-_43499608 8.921 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr16_+_48994185 8.587 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr2_+_118813995 8.425 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr1_+_187215501 8.219 ENSMUST00000097443.3
ENSMUST00000065573.7
ENSMUST00000110943.2
ENSMUST00000044812.5
 Gpatch2



G patch domain containing 2



chrX_+_100625737 7.550 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr17_-_33890584 7.371 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr3_+_87930256 6.931 ENSMUST00000055984.6
 Isg20l2
interferon stimulated exonuclease gene 20-like 2
chr4_-_45320580 6.813 ENSMUST00000030003.3
 Exosc3
exosome component 3
chr2_-_130179310 6.714 ENSMUST00000103199.4
 Snrpb
small nuclear ribonucleoprotein B
chr16_-_18811972 6.689 ENSMUST00000000028.7
ENSMUST00000115585.1
 Cdc45

cell division cycle 45


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 676 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 74.0 GO:0008380 RNA splicing(GO:0008380)
1.9 34.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.0 32.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.3 27.4 GO:0051028 mRNA transport(GO:0051028)
0.3 26.4 GO:0006413 translational initiation(GO:0006413)
0.6 23.3 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
5.3 21.1 GO:0019323 pentose catabolic process(GO:0019323)
0.9 19.9 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.2 15.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 14.9 GO:0008360 regulation of cell shape(GO:0008360)
4.5 13.6 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.5 13.5 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.5 13.3 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.9 12.0 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.8 11.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 11.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.6 11.0 GO:0045116 protein neddylation(GO:0045116)
0.4 10.9 GO:0006270 DNA replication initiation(GO:0006270)
0.5 10.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
1.2 10.6 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 314 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 41.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.5 33.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.9 30.5 GO:0035371 microtubule plus-end(GO:0035371)
0.6 30.1 GO:0005871 kinesin complex(GO:0005871)
0.5 25.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.3 24.1 GO:0031616 spindle pole centrosome(GO:0031616)
2.7 21.5 GO:0005818 aster(GO:0005818)
0.0 20.2 GO:0005730 nucleolus(GO:0005730)
0.1 17.9 GO:0005667 transcription factor complex(GO:0005667)
1.5 15.0 GO:0031595 nuclear proteasome complex(GO:0031595)
0.2 14.7 GO:0005681 spliceosomal complex(GO:0005681)
0.1 14.7 GO:0016607 nuclear speck(GO:0016607)
2.3 13.8 GO:0031262 Ndc80 complex(GO:0031262)
0.2 13.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.6 12.8 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.7 12.5 GO:0022624 proteasome accessory complex(GO:0022624)
0.2 10.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 10.9 GO:0031965 nuclear membrane(GO:0031965)
2.1 10.6 GO:0048476 Holliday junction resolvase complex(GO:0048476)
1.2 10.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 420 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 73.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 27.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.4 26.3 GO:0003777 microtubule motor activity(GO:0003777)
2.1 18.6 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.6 16.7 GO:0017025 TBP-class protein binding(GO:0017025)
5.5 16.5 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
1.0 15.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
1.0 14.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 13.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.8 13.0 GO:0003680 AT DNA binding(GO:0003680)
0.3 12.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.7 11.6 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 11.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.4 11.0 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.2 10.8 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.2 10.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 10.7 GO:0005525 GTP binding(GO:0005525)
0.8 10.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 10.2 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.6 10.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 37.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.6 29.2 PID_ATR_PATHWAY ATR signaling pathway
0.2 23.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 19.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 13.5 PID_MYC_PATHWAY C-MYC pathway
0.2 10.0 PID_E2F_PATHWAY E2F transcription factor network
0.1 9.2 PID_CDC42_PATHWAY CDC42 signaling events
0.3 8.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 8.1 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.3 7.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 7.6 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 7.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.2 7.4 PID_PLK1_PATHWAY PLK1 signaling events
0.1 7.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 6.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.2 6.8 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.2 6.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 6.2 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.3 4.7 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 4.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 42.1 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.5 41.1 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.4 39.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 36.4 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
1.3 35.5 REACTOME_KINESINS Genes involved in Kinesins
0.6 34.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.8 21.6 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 20.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 13.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 11.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.8 10.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 10.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.4 9.7 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 8.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.4 8.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5 8.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 7.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 7.2 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.7 7.0 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.2 6.9 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC