Motif ID: Etv3_Erf_Fev_Elk4_Elk1_Elk3
Z-value: 0.813






Transcription factors associated with Etv3_Erf_Fev_Elk4_Elk1_Elk3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Elk1 | ENSMUSG00000009406.7 | Elk1 |
Elk3 | ENSMUSG00000008398.8 | Elk3 |
Elk4 | ENSMUSG00000026436.9 | Elk4 |
Erf | ENSMUSG00000040857.9 | Erf |
Etv3 | ENSMUSG00000003382.12 | Etv3 |
Fev | ENSMUSG00000055197.4 | Fev |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Elk1 | mm10_v2_chrX_-_20950597_20950613 | 0.64 | 1.6e-07 | Click! |
Elk4 | mm10_v2_chr1_+_132007606_132007634 | 0.60 | 1.1e-06 | Click! |
Erf | mm10_v2_chr7_-_25250720_25250761 | -0.42 | 1.4e-03 | Click! |
Etv3 | mm10_v2_chr3_+_87525572_87525643 | 0.40 | 2.3e-03 | Click! |
Elk3 | mm10_v2_chr10_-_93311073_93311161 | -0.26 | 5.8e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 454 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 12.4 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
0.7 | 11.8 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
0.2 | 9.8 | GO:0045761 | regulation of adenylate cyclase activity(GO:0045761) |
0.3 | 9.6 | GO:0006829 | zinc II ion transport(GO:0006829) |
0.1 | 9.5 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
3.0 | 9.0 | GO:0048611 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) |
0.4 | 9.0 | GO:0030033 | microvillus assembly(GO:0030033) |
1.0 | 8.3 | GO:0036506 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
0.5 | 7.3 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
0.4 | 7.1 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
2.0 | 6.1 | GO:0019085 | early viral transcription(GO:0019085) |
1.2 | 6.1 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
0.3 | 6.0 | GO:0002076 | osteoblast development(GO:0002076) |
0.1 | 5.9 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
1.4 | 5.5 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
0.6 | 5.5 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
0.1 | 5.5 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
0.2 | 5.2 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
1.2 | 4.9 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
0.5 | 4.9 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 188 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 18.0 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
0.0 | 12.1 | GO:0005768 | endosome(GO:0005768) |
1.5 | 11.8 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
0.1 | 11.7 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
2.2 | 11.1 | GO:1990745 | EARP complex(GO:1990745) |
0.1 | 9.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.3 | 8.8 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
0.0 | 8.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
1.2 | 8.3 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
0.4 | 7.9 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
0.8 | 7.6 | GO:0071439 | clathrin complex(GO:0071439) |
0.8 | 7.0 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
0.0 | 6.8 | GO:0005769 | early endosome(GO:0005769) |
1.6 | 6.3 | GO:1990769 | proximal neuron projection(GO:1990769) |
0.0 | 6.3 | GO:0016324 | apical plasma membrane(GO:0016324) |
1.0 | 5.8 | GO:0097443 | sorting endosome(GO:0097443) |
0.0 | 5.8 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
0.9 | 5.5 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807) |
0.7 | 5.5 | GO:0097427 | microtubule bundle(GO:0097427) |
0.1 | 5.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 270 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 28.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
0.0 | 19.9 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
0.0 | 16.6 | GO:0008270 | zinc ion binding(GO:0008270) |
0.2 | 16.2 | GO:0030276 | clathrin binding(GO:0030276) |
0.1 | 14.6 | GO:0017137 | Rab GTPase binding(GO:0017137) |
0.3 | 13.4 | GO:0070063 | RNA polymerase binding(GO:0070063) |
0.2 | 12.2 | GO:0019905 | syntaxin binding(GO:0019905) |
0.6 | 11.3 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
0.6 | 9.8 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
0.6 | 8.1 | GO:0015643 | toxic substance binding(GO:0015643) |
0.3 | 7.4 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
0.3 | 6.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.1 | 6.2 | GO:0051219 | phosphoprotein binding(GO:0051219) |
0.1 | 5.6 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
1.4 | 5.5 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
0.1 | 5.5 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
0.0 | 5.4 | GO:0046873 | metal ion transmembrane transporter activity(GO:0046873) |
0.0 | 5.1 | GO:0003779 | actin binding(GO:0003779) |
0.4 | 5.0 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
1.0 | 4.9 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 53 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 15.0 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
0.2 | 8.6 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
0.2 | 7.2 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
0.2 | 6.7 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
0.2 | 5.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
0.2 | 5.3 | PID_ARF_3PATHWAY | Arf1 pathway |
0.1 | 4.9 | PID_BMP_PATHWAY | BMP receptor signaling |
0.2 | 4.8 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.1 | 4.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.1 | 4.3 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
0.1 | 4.2 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
0.0 | 4.2 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
0.0 | 2.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.2 | 2.7 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
0.1 | 2.6 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
0.3 | 2.4 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.1 | 2.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.1 | 2.3 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.1 | 2.2 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
0.1 | 2.0 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 92 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 19.7 | REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
0.3 | 12.0 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
0.2 | 9.4 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.4 | 9.1 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
0.6 | 8.6 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
0.4 | 7.5 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
0.0 | 6.5 | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | Genes involved in Generic Transcription Pathway |
0.0 | 6.2 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.2 | 5.0 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.4 | 4.5 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.3 | 4.5 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
0.3 | 4.5 | REACTOME_PHOSPHORYLATION_OF_THE_APC_C | Genes involved in Phosphorylation of the APC/C |
0.2 | 3.9 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.3 | 3.7 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
0.1 | 3.7 | REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
0.1 | 3.7 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
0.2 | 3.4 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
0.1 | 3.3 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
0.0 | 3.3 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
0.2 | 3.1 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |