Motif ID: Etv3_Erf_Fev_Elk4_Elk1_Elk3

Z-value: 0.813


Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elk1mm10_v2_chrX_-_20950597_209506130.641.6e-07Click!
Elk4mm10_v2_chr1_+_132007606_1320076340.601.1e-06Click!
Erfmm10_v2_chr7_-_25250720_25250761-0.421.4e-03Click!
Etv3mm10_v2_chr3_+_87525572_875256430.402.3e-03Click!
Elk3mm10_v2_chr10_-_93311073_93311161-0.265.8e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Etv3_Erf_Fev_Elk4_Elk1_Elk3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_163602331 9.108 ENSMUST00000152135.1
Ttpal
tocopherol (alpha) transfer protein-like
chr11_+_54522872 6.078 ENSMUST00000108895.1
ENSMUST00000101206.3
Rapgef6

Rap guanine nucleotide exchange factor (GEF) 6

chr12_+_80644212 6.038 ENSMUST00000085245.5
Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr12_-_84970814 5.394 ENSMUST00000165886.1
ENSMUST00000167448.1
ENSMUST00000043169.7
Arel1


apoptosis resistant E3 ubiquitin protein ligase 1


chr6_+_86849488 5.378 ENSMUST00000089519.6
ENSMUST00000113668.1
Aak1

AP2 associated kinase 1

chr17_+_33955902 4.999 ENSMUST00000173196.2
Vps52
vacuolar protein sorting 52 (yeast)
chr8_-_69791170 4.940 ENSMUST00000131784.1
Zfp866
zinc finger protein 866
chr16_-_87432597 4.902 ENSMUST00000039449.7
Ltn1
listerin E3 ubiquitin protein ligase 1
chr7_+_122067164 4.900 ENSMUST00000033158.4
Ubfd1
ubiquitin family domain containing 1
chr9_-_44965519 4.867 ENSMUST00000125642.1
ENSMUST00000117506.1
ENSMUST00000117549.1
Ube4a


ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)


chr11_+_83299005 4.740 ENSMUST00000176944.1
Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr5_-_3803081 4.701 ENSMUST00000043551.6
Ankib1
ankyrin repeat and IBR domain containing 1
chr1_-_133025330 4.650 ENSMUST00000067429.3
ENSMUST00000067398.6
Mdm4

transformed mouse 3T3 cell double minute 4

chr12_-_64965496 4.613 ENSMUST00000021331.7
Klhl28
kelch-like 28
chrX_-_12762069 4.562 ENSMUST00000096495.4
ENSMUST00000076016.5
Med14

mediator complex subunit 14

chr9_-_110476637 4.555 ENSMUST00000111934.1
ENSMUST00000068025.6
Klhl18

kelch-like 18

chr1_+_118389058 4.360 ENSMUST00000049404.6
ENSMUST00000070989.7
ENSMUST00000165223.1
ENSMUST00000178710.1
Clasp1



CLIP associating protein 1



chr9_+_56418624 4.353 ENSMUST00000034879.3
Hmg20a
high mobility group 20A
chr9_-_29411736 4.341 ENSMUST00000115236.1
Ntm
neurotrimin
chr7_+_127876796 4.298 ENSMUST00000131000.1
Zfp646
zinc finger protein 646

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 454 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 12.4 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.7 11.8 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.2 9.8 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.3 9.6 GO:0006829 zinc II ion transport(GO:0006829)
0.1 9.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
3.0 9.0 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.4 9.0 GO:0030033 microvillus assembly(GO:0030033)
1.0 8.3 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.5 7.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.4 7.1 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
2.0 6.1 GO:0019085 early viral transcription(GO:0019085)
1.2 6.1 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.3 6.0 GO:0002076 osteoblast development(GO:0002076)
0.1 5.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
1.4 5.5 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.6 5.5 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.1 5.5 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.2 5.2 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
1.2 4.9 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
0.5 4.9 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 18.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 12.1 GO:0005768 endosome(GO:0005768)
1.5 11.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 11.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
2.2 11.1 GO:1990745 EARP complex(GO:1990745)
0.1 9.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 8.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 8.8 GO:0005802 trans-Golgi network(GO:0005802)
1.2 8.3 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.4 7.9 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.8 7.6 GO:0071439 clathrin complex(GO:0071439)
0.8 7.0 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 6.8 GO:0005769 early endosome(GO:0005769)
1.6 6.3 GO:1990769 proximal neuron projection(GO:1990769)
0.0 6.3 GO:0016324 apical plasma membrane(GO:0016324)
1.0 5.8 GO:0097443 sorting endosome(GO:0097443)
0.0 5.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.9 5.5 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.7 5.5 GO:0097427 microtubule bundle(GO:0097427)
0.1 5.5 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 270 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 28.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 19.9 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 16.6 GO:0008270 zinc ion binding(GO:0008270)
0.2 16.2 GO:0030276 clathrin binding(GO:0030276)
0.1 14.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 13.4 GO:0070063 RNA polymerase binding(GO:0070063)
0.2 12.2 GO:0019905 syntaxin binding(GO:0019905)
0.6 11.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.6 9.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.6 8.1 GO:0015643 toxic substance binding(GO:0015643)
0.3 7.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3 6.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 6.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 5.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
1.4 5.5 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 5.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 5.4 GO:0046873 metal ion transmembrane transporter activity(GO:0046873)
0.0 5.1 GO:0003779 actin binding(GO:0003779)
0.4 5.0 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
1.0 4.9 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.0 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 8.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.2 7.2 SIG_CHEMOTAXIS Genes related to chemotaxis
0.2 6.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.2 5.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 5.3 PID_ARF_3PATHWAY Arf1 pathway
0.1 4.9 PID_BMP_PATHWAY BMP receptor signaling
0.2 4.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 4.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 4.3 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.1 4.2 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 4.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 2.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 2.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 2.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.3 2.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.2 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 2.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 19.7 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.3 12.0 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 9.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.4 9.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.6 8.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.4 7.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 6.5 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.0 6.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 5.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4 4.5 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.3 4.5 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.3 4.5 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.2 3.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 3.7 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.1 3.7 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 3.7 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 3.4 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 3.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 3.3 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 3.1 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC