Motif ID: Etv4

Z-value: 0.707


Transcription factors associated with Etv4:

Gene SymbolEntrez IDGene Name
Etv4 ENSMUSG00000017724.8 Etv4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv4mm10_v2_chr11_-_101785252_1017853710.162.6e-01Click!


Activity profile for motif Etv4.

activity profile for motif Etv4


Sorted Z-values histogram for motif Etv4

Sorted Z-values for motif Etv4



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_56133817 6.630 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr6_+_5725639 6.378 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr15_-_66969616 6.144 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr15_-_66812593 5.491 ENSMUST00000100572.3
 Sla
src-like adaptor
chr9_-_29411736 5.319 ENSMUST00000115236.1
 Ntm
neurotrimin
chr9_+_107935876 5.208 ENSMUST00000035700.8
 Camkv
CaM kinase-like vesicle-associated
chr11_-_76509419 4.495 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr13_+_83504032 4.432 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr7_+_45627482 4.360 ENSMUST00000057927.7
 Rasip1
Ras interacting protein 1
chr3_+_95526777 4.308 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr1_-_56969864 4.062 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr6_+_8259288 4.022 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr8_+_70501116 3.925 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr1_-_56969827 3.786 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr6_+_125552948 3.769 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr13_+_109632760 3.753 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr7_+_30413744 3.452 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr17_+_3397189 3.252 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr9_-_29412204 3.237 ENSMUST00000115237.1
 Ntm
neurotrimin
chr11_+_103171081 3.154 ENSMUST00000042286.5
 Fmnl1
formin-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 301 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.7 GO:0002076 osteoblast development(GO:0002076)
0.1 6.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.6 6.4 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 5.7 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.5 5.5 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.9 5.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.5 4.7 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.5 4.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 4.6 GO:0032526 response to retinoic acid(GO:0032526)
0.9 4.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
1.5 4.4 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.8 4.2 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.3 4.2 GO:0010447 response to acidic pH(GO:0010447)
0.0 4.0 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.7 3.9 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 3.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.9 3.8 GO:0014042 positive regulation of neuron maturation(GO:0014042)
0.3 3.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 3.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 3.5 GO:2001204 regulation of osteoclast development(GO:2001204)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 10.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 8.4 GO:0009986 cell surface(GO:0009986)
0.2 7.1 GO:0030131 clathrin adaptor complex(GO:0030131)
2.1 6.4 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.1 5.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.1 5.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.2 5.2 GO:0031430 M band(GO:0031430)
0.1 4.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 4.0 GO:0000139 Golgi membrane(GO:0000139)
1.3 3.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.8 3.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 3.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.4 3.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.5 3.4 GO:0071439 clathrin complex(GO:0071439)
0.5 3.3 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.5 3.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 3.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 3.2 GO:0030017 sarcomere(GO:0030017)
0.0 3.2 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 GO:0008565 protein transporter activity(GO:0008565)
0.2 7.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 6.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 6.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 6.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 6.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 5.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 5.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 5.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.1 5.3 GO:0097643 amylin receptor activity(GO:0097643)
0.1 4.7 GO:0008083 growth factor activity(GO:0008083)
0.0 4.6 GO:0017124 SH3 domain binding(GO:0017124)
0.2 4.4 GO:0035198 miRNA binding(GO:0035198)
0.0 4.4 GO:0000149 SNARE binding(GO:0000149)
0.4 4.3 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 4.3 GO:0043394 proteoglycan binding(GO:0043394)
0.2 4.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.6 3.9 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.2 3.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.9 3.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 5.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 5.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 5.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 5.4 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 4.6 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.1 4.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 3.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 3.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 3.4 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 3.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 2.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.5 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 2.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.1 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.0 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 7.3 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.2 7.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 5.3 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.2 5.0 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.3 4.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 4.6 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ Genes involved in Formation of RNA Pol II elongation complex
1.4 4.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 4.1 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 4.0 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.4 3.6 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 3.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 3.0 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.2 2.8 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0 2.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.4 2.3 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 2.3 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 2.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 2.2 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation