Motif ID: Etv6
Z-value: 0.757
Transcription factors associated with Etv6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Etv6 | ENSMUSG00000030199.10 | Etv6 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Etv6 | mm10_v2_chr6_+_134035691_134035717 | -0.26 | 5.6e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.4 | 1.7 | GO:0018307 | tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307) |
| 0.4 | 1.2 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 0.4 | 1.1 | GO:1903538 | meiotic sister chromatid cohesion, centromeric(GO:0051754) meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
| 0.4 | 1.1 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
| 0.4 | 1.1 | GO:0090004 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.3 | 2.2 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.3 | 2.4 | GO:0036506 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 0.2 | 0.7 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.2 | 0.7 | GO:0016561 | protein import into peroxisome matrix, translocation(GO:0016561) |
| 0.2 | 0.6 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.2 | 0.6 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.2 | 1.6 | GO:0071569 | protein ufmylation(GO:0071569) |
| 0.2 | 1.4 | GO:0060046 | regulation of acrosome reaction(GO:0060046) |
| 0.2 | 0.5 | GO:0060084 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084) |
| 0.2 | 0.6 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.2 | 0.9 | GO:0035878 | nail development(GO:0035878) |
| 0.2 | 0.6 | GO:1903750 | MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135) regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 0.2 | 0.6 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.1 | 0.4 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.1 | 0.8 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.1 | 0.9 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.1 | 0.5 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.1 | 1.1 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.1 | 0.6 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.1 | 2.0 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.1 | 0.6 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
| 0.1 | 0.2 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
| 0.1 | 0.3 | GO:0031990 | mRNA export from nucleus in response to heat stress(GO:0031990) |
| 0.1 | 0.3 | GO:0039533 | regulation of MDA-5 signaling pathway(GO:0039533) |
| 0.1 | 0.5 | GO:0000393 | spliceosomal conformational changes to generate catalytic conformation(GO:0000393) |
| 0.1 | 0.3 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.1 | 1.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 1.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 0.3 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.1 | 0.5 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.1 | 1.3 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.1 | 0.4 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
| 0.1 | 0.3 | GO:0019043 | establishment of viral latency(GO:0019043) |
| 0.1 | 0.8 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 0.1 | 0.9 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.1 | 0.4 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
| 0.1 | 0.8 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.1 | 0.6 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 0.1 | 0.5 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.1 | 0.9 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.1 | 0.9 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.1 | 0.6 | GO:0023035 | CD40 signaling pathway(GO:0023035) |
| 0.1 | 0.5 | GO:0048318 | axial mesoderm development(GO:0048318) |
| 0.1 | 0.4 | GO:0048793 | pronephros development(GO:0048793) |
| 0.1 | 1.7 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 0.7 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.1 | 0.6 | GO:0070365 | hepatocyte differentiation(GO:0070365) |
| 0.1 | 1.6 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.1 | 0.2 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
| 0.1 | 0.1 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.1 | 0.3 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.1 | 0.5 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.1 | 0.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.9 | GO:0007289 | spermatid nucleus differentiation(GO:0007289) |
| 0.0 | 0.4 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.0 | 0.2 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.0 | 0.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 1.9 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.0 | 0.4 | GO:2001197 | regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197) |
| 0.0 | 1.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.5 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.0 | 0.6 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.3 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 0.3 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.0 | 0.9 | GO:0006903 | vesicle targeting(GO:0006903) |
| 0.0 | 3.4 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 0.3 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.0 | 0.3 | GO:0010324 | membrane invagination(GO:0010324) |
| 0.0 | 0.1 | GO:1901069 | guanosine-containing compound catabolic process(GO:1901069) |
| 0.0 | 0.2 | GO:0070197 | meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.0 | 0.2 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.0 | 0.1 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) |
| 0.0 | 0.4 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.0 | 0.7 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 0.1 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.0 | 0.2 | GO:0006983 | ER overload response(GO:0006983) |
| 0.0 | 0.4 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 0.9 | GO:0070266 | necroptotic process(GO:0070266) |
| 0.0 | 0.2 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.0 | 0.5 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 0.6 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.1 | GO:0032055 | negative regulation of translation in response to stress(GO:0032055) |
| 0.0 | 0.4 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.1 | GO:0030913 | paranodal junction assembly(GO:0030913) |
| 0.0 | 0.5 | GO:0035357 | peroxisome proliferator activated receptor signaling pathway(GO:0035357) |
| 0.0 | 0.3 | GO:0048008 | platelet-derived growth factor receptor signaling pathway(GO:0048008) |
| 0.0 | 0.7 | GO:0045026 | plasma membrane fusion(GO:0045026) |
| 0.0 | 0.7 | GO:1903427 | negative regulation of reactive oxygen species biosynthetic process(GO:1903427) |
| 0.0 | 1.1 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
| 0.0 | 0.2 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 0.5 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.4 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.3 | GO:1904424 | regulation of GTP binding(GO:1904424) |
| 0.0 | 2.2 | GO:0006413 | translational initiation(GO:0006413) |
| 0.0 | 1.0 | GO:0001510 | RNA methylation(GO:0001510) |
| 0.0 | 0.7 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.0 | 0.0 | GO:0045896 | regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897) |
| 0.0 | 0.7 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 0.0 | 0.2 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 0.0 | 2.6 | GO:0008643 | carbohydrate transport(GO:0008643) |
| 0.0 | 0.3 | GO:0044364 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 0.0 | 0.7 | GO:0061512 | protein localization to cilium(GO:0061512) |
| 0.0 | 0.5 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.5 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.7 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 0.9 | GO:0097190 | apoptotic signaling pathway(GO:0097190) |
| 0.0 | 0.1 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.0 | 0.4 | GO:0071174 | mitotic spindle checkpoint(GO:0071174) |
| 0.0 | 0.0 | GO:0044130 | negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:1903095 | microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095) |
| 0.6 | 1.7 | GO:0099631 | postsynaptic endocytic zone cytoplasmic component(GO:0099631) |
| 0.4 | 1.6 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.3 | 2.4 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.3 | 1.3 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.3 | 0.8 | GO:0044614 | nuclear pore cytoplasmic filaments(GO:0044614) |
| 0.2 | 2.0 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.2 | 0.7 | GO:0031533 | mRNA cap methyltransferase complex(GO:0031533) |
| 0.2 | 1.4 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
| 0.2 | 0.8 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.2 | 1.7 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.2 | 1.3 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.2 | 0.9 | GO:0097441 | basilar dendrite(GO:0097441) |
| 0.2 | 2.0 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.2 | 0.5 | GO:0034657 | GID complex(GO:0034657) |
| 0.2 | 0.6 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.1 | 1.9 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 0.6 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.1 | 0.6 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.1 | 0.5 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.1 | 0.4 | GO:0098888 | extrinsic component of presynaptic membrane(GO:0098888) |
| 0.1 | 0.6 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 1.7 | GO:0033178 | proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178) |
| 0.1 | 0.4 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.1 | 0.6 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.1 | 0.5 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 0.5 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 0.4 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.1 | 0.7 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 1.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 0.5 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.1 | 0.6 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 0.7 | GO:0033176 | proton-transporting V-type ATPase complex(GO:0033176) |
| 0.1 | 0.3 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.1 | 0.6 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.1 | 0.9 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 0.8 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 0.4 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.1 | 0.6 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 0.7 | GO:0044439 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.1 | 1.2 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.7 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 1.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.9 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 1.4 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.2 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.0 | 0.4 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.4 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 0.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 1.0 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.3 | GO:0000243 | commitment complex(GO:0000243) |
| 0.0 | 1.9 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 0.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.4 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 1.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.1 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.6 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.3 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 2.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.4 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.0 | 0.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.2 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 0.2 | GO:0034518 | mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518) |
| 0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 1.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 1.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.0 | GO:0044753 | amphisome(GO:0044753) |
| 0.0 | 0.2 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.3 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.0 | 4.0 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.3 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.4 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.6 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 0.4 | 2.2 | GO:0004525 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.3 | 1.7 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.3 | 0.8 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.2 | 0.7 | GO:0004482 | mRNA (guanine-N7-)-methyltransferase activity(GO:0004482) |
| 0.2 | 0.6 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.2 | 2.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.2 | 0.5 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.2 | 0.6 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) arginine binding(GO:0034618) |
| 0.1 | 0.4 | GO:0000992 | polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) |
| 0.1 | 1.7 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 1.2 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 1.3 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.1 | 1.1 | GO:0071253 | connexin binding(GO:0071253) |
| 0.1 | 0.6 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 0.9 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.1 | 0.4 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.1 | 1.6 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.1 | 1.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 0.5 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.1 | 0.3 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.1 | 0.6 | GO:0046790 | virion binding(GO:0046790) |
| 0.1 | 0.7 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.1 | 0.8 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.1 | 0.4 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 0.3 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.1 | 0.9 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.1 | 0.4 | GO:0089720 | caspase binding(GO:0089720) |
| 0.1 | 0.2 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.1 | 0.3 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.1 | 3.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 0.4 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.1 | 0.5 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 1.2 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.7 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.0 | 0.2 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.0 | 0.6 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 1.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.7 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.0 | 1.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.3 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.0 | 0.4 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.6 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.5 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.5 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) |
| 0.0 | 2.2 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.0 | 1.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 2.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 1.6 | GO:0001786 | phosphatidylserine binding(GO:0001786) calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 1.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.4 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.5 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.5 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 1.2 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.0 | 0.3 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.6 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.0 | 0.3 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 0.3 | GO:0035004 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) phosphatidylinositol 3-kinase activity(GO:0035004) |
| 0.0 | 0.4 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 1.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.8 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 0.9 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.9 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 1.5 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 1.1 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 0.1 | GO:0050347 | trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347) |
| 0.0 | 1.2 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.0 | 0.1 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.0 | 0.1 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.0 | 0.8 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 0.5 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.8 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.5 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.5 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.0 | 0.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.7 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.1 | 2.9 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 1.7 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.5 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.5 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 3.7 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 0.3 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.4 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.9 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.3 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.9 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 2.0 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 1.6 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.1 | 0.8 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 2.5 | REACTOME_MICRORNA_MIRNA_BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 2.3 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 1.7 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 1.3 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 0.6 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 1.9 | REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.1 | 0.9 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 0.4 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 2.6 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 0.5 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 0.7 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 0.9 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 1.9 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.9 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 1.1 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 2.5 | REACTOME_ER_PHAGOSOME_PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 0.4 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.9 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.6 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.3 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.1 | REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 1.3 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.3 | REACTOME_SIGNAL_TRANSDUCTION_BY_L1 | Genes involved in Signal transduction by L1 |
| 0.0 | 1.7 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.4 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.9 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 2.0 | REACTOME_REGULATION_OF_INSULIN_SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.0 | 0.3 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.3 | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 0.6 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.3 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 1.3 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.4 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.5 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.6 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.8 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.2 | REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 0.8 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.9 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
