Motif ID: Evx2
Z-value: 0.799
Transcription factors associated with Evx2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Evx2 | ENSMUSG00000001815.9 | Evx2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.8 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 1.0 | 3.1 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 0.7 | 14.5 | GO:0007530 | sex determination(GO:0007530) |
| 0.7 | 2.8 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.6 | 11.2 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.5 | 8.4 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.4 | 9.0 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.3 | 1.9 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.2 | 4.6 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.2 | 1.6 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.2 | 1.4 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.2 | 1.6 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 7.3 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.1 | 6.3 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.1 | 4.3 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 2.8 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.1 | 0.8 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 0.8 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.1 | 4.1 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 0.7 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 0.3 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.0 | 0.7 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.2 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.0 | 3.9 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 0.4 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 0.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.0 | 2.2 | GO:0048489 | synaptic vesicle transport(GO:0048489) establishment of synaptic vesicle localization(GO:0097480) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.4 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 1.9 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 9.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 12.9 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.1 | 4.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 6.3 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 0.2 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 0.9 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 11.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.4 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.8 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 4.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.5 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 1.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.1 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.3 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 1.1 | 6.3 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.7 | 9.0 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.7 | 2.8 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.6 | 4.4 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.4 | 14.5 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.3 | 1.6 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 1.4 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 1.6 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 3.1 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 0.2 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.0 | 4.0 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.3 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.0 | 0.7 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 1.9 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 26.8 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 0.8 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 3.9 | GO:0008017 | microtubule binding(GO:0008017) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.3 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 11.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 3.9 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 6.3 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.6 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.7 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.2 | 4.1 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.2 | 3.9 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 7.2 | REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.1 | 1.4 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 1.6 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.8 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 1.9 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.8 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.8 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.1 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
