Motif ID: Ezh2_Atf2_Ikzf1

Z-value: 1.690

Transcription factors associated with Ezh2_Atf2_Ikzf1:

Gene SymbolEntrez IDGene Name
Atf2 ENSMUSG00000027104.12 Atf2
Ezh2 ENSMUSG00000029687.10 Ezh2
Ikzf1 ENSMUSG00000018654.11 Ikzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf2mm10_v2_chr2_-_73892588_738926160.776.9e-12Click!
Ezh2mm10_v2_chr6_-_47594967_475950470.201.5e-01Click!


Activity profile for motif Ezh2_Atf2_Ikzf1.

activity profile for motif Ezh2_Atf2_Ikzf1


Sorted Z-values histogram for motif Ezh2_Atf2_Ikzf1

Sorted Z-values for motif Ezh2_Atf2_Ikzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ezh2_Atf2_Ikzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_34745952 16.502 ENSMUST00000123823.1
ENSMUST00000136907.1
ENSMUST00000126181.1
 Cald1


caldesmon 1


chr1_-_190170671 16.336 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr6_+_34746368 13.006 ENSMUST00000142716.1
 Cald1
caldesmon 1
chr9_-_117252450 12.491 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
 Rbms3


RNA binding motif, single stranded interacting protein


chr2_+_152081529 12.154 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr1_-_190170178 11.186 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr6_+_141524379 10.678 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr2_+_4300462 9.616 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr4_-_82505707 8.333 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr14_+_28504736 7.528 ENSMUST00000063465.4
 Wnt5a
wingless-related MMTV integration site 5A
chr2_-_66410064 7.186 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chr16_+_43503607 7.045 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chr3_-_86548268 6.859 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr4_-_53159885 6.720 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr1_+_66175272 6.650 ENSMUST00000156636.2
 Map2
microtubule-associated protein 2
chr17_-_90455872 6.546 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr16_+_43363855 6.413 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr4_-_110290884 6.315 ENSMUST00000142722.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr13_+_54371340 6.278 ENSMUST00000026985.8
 Cplx2
complexin 2
chr16_+_43247278 6.119 ENSMUST00000114691.1
ENSMUST00000079441.6
 Zbtb20

zinc finger and BTB domain containing 20


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 433 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 31.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
9.8 29.4 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.4 18.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.3 16.2 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
3.9 15.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 13.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 12.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.8 12.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 11.8 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.3 11.0 GO:2001222 regulation of neuron migration(GO:2001222)
0.9 10.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
3.2 9.7 GO:0060067 cervix development(GO:0060067)
1.6 9.6 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
2.3 9.1 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 8.3 GO:0045727 positive regulation of translation(GO:0045727)
0.8 8.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 8.0 GO:0001919 regulation of receptor recycling(GO:0001919)
0.3 7.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
1.4 7.2 GO:2000481 positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.3 7.1 GO:0010172 embryonic body morphogenesis(GO:0010172)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 31.7 GO:0030478 actin cap(GO:0030478)
2.1 18.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.8 16.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 14.0 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 12.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.8 12.6 GO:0042788 polysomal ribosome(GO:0042788)
0.0 11.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 9.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
1.1 9.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.6 9.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.7 8.2 GO:0032584 growth cone membrane(GO:0032584)
0.4 7.9 GO:0032279 asymmetric synapse(GO:0032279)
0.2 7.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.6 6.3 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.3 5.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.3 5.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 5.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.9 5.2 GO:0044308 axonal spine(GO:0044308)
0.2 5.1 GO:0071565 nBAF complex(GO:0071565)
0.1 5.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 283 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 29.4 GO:0050693 LBD domain binding(GO:0050693)
0.0 20.4 GO:0003779 actin binding(GO:0003779)
0.5 18.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
2.2 17.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 17.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.6 11.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.7 10.7 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 10.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.8 9.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.9 9.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 8.9 GO:0005509 calcium ion binding(GO:0005509)
0.4 8.8 GO:0031402 sodium ion binding(GO:0031402)
0.1 8.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 8.1 GO:0030674 protein binding, bridging(GO:0030674)
1.3 8.0 GO:0005042 netrin receptor activity(GO:0005042)
1.1 8.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
2.5 7.5 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 7.5 GO:0017124 SH3 domain binding(GO:0017124)
0.5 7.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 7.0 GO:0017091 AU-rich element binding(GO:0017091)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.7 PID_LKB1_PATHWAY LKB1 signaling events
0.2 12.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 12.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 11.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 7.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 5.9 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 5.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 5.1 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 4.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.9 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 2.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 2.0 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 1.9 ST_GA13_PATHWAY G alpha 13 Pathway
0.1 1.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.7 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 1.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 1.7 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 28.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.5 13.0 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.5 11.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.3 10.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.2 10.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.7 7.3 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 7.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 6.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4 4.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 4.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 4.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 4.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 3.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 3.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 3.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.5 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.3 3.3 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 3.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.9 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 2.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation