Motif ID: Figla

Z-value: 0.684


Transcription factors associated with Figla:

Gene SymbolEntrez IDGene Name
Figla ENSMUSG00000030001.3 Figla



Activity profile for motif Figla.

activity profile for motif Figla


Sorted Z-values histogram for motif Figla

Sorted Z-values for motif Figla



Network of associatons between targets according to the STRING database.



First level regulatory network of Figla

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_164769892 8.762 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr15_-_78773452 6.824 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_+_99864476 6.531 ENSMUST00000092694.3
 Gm11559
predicted gene 11559
chr10_+_26229707 6.406 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_-_119053339 5.885 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr5_+_123749696 5.492 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr1_+_74791516 5.226 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr7_+_19094594 5.213 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr13_-_100786402 5.201 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr15_+_25622525 4.946 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr2_+_19909769 4.409 ENSMUST00000114610.1
 Etl4
enhancer trap locus 4
chr14_-_20181773 4.289 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr2_+_20519776 4.077 ENSMUST00000114604.2
ENSMUST00000066509.3
 Etl4

enhancer trap locus 4

chr12_+_109459843 4.028 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr7_-_127218390 3.900 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr7_-_144939823 3.892 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr2_+_168081004 3.857 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr8_+_127064107 3.759 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr6_+_47244359 3.696 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chrX_-_23266751 3.624 ENSMUST00000115316.2
 Klhl13
kelch-like 13

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.5 GO:0048706 embryonic skeletal system development(GO:0048706)
1.8 8.8 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
1.8 7.4 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
1.7 6.9 GO:0060032 notochord regression(GO:0060032)
0.6 6.8 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.1 5.5 GO:0035063 nuclear speck organization(GO:0035063)
1.7 5.2 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.5 5.2 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.4 5.2 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.1 4.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 4.0 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.6 3.9 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.6 3.8 GO:0003383 apical constriction(GO:0003383)
0.7 3.7 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.4 3.7 GO:0030035 microspike assembly(GO:0030035)
0.0 3.6 GO:0000910 cytokinesis(GO:0000910)
0.0 3.4 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.3 3.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.0 3.1 GO:0036292 DNA rewinding(GO:0036292)
1.0 3.0 GO:1904274 tricellular tight junction assembly(GO:1904274)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.8 7.4 GO:0072687 meiotic spindle(GO:0072687)
0.5 6.9 GO:0097542 ciliary tip(GO:0097542)
0.1 6.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 6.7 GO:0030496 midbody(GO:0030496)
1.8 5.5 GO:1990423 RZZ complex(GO:1990423)
1.3 5.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 4.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 4.4 GO:0016459 myosin complex(GO:0016459)
0.1 3.9 GO:0030673 axolemma(GO:0030673)
0.1 3.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 3.8 GO:0033269 internode region of axon(GO:0033269)
0.8 3.4 GO:0008537 proteasome activator complex(GO:0008537)
0.0 3.3 GO:0031594 neuromuscular junction(GO:0031594)
0.1 3.1 GO:0043596 nuclear replication fork(GO:0043596)
0.4 3.0 GO:0042627 chylomicron(GO:0042627)
0.0 2.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 2.5 GO:0016605 PML body(GO:0016605)
0.1 2.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 2.3 GO:0005938 cell cortex(GO:0005938)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 8.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 7.7 GO:0005525 GTP binding(GO:0005525)
2.3 6.8 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 6.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.3 5.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 5.2 GO:0005109 frizzled binding(GO:0005109)
0.1 4.9 GO:0030507 spectrin binding(GO:0030507)
0.2 4.6 GO:0070064 proline-rich region binding(GO:0070064)
0.3 4.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 3.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4 3.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.4 3.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 3.1 GO:0036310 annealing helicase activity(GO:0036310)
0.3 2.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 2.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.6 GO:0002039 p53 binding(GO:0002039)
0.8 2.5 GO:0070052 collagen V binding(GO:0070052)
0.1 2.3 GO:0030276 clathrin binding(GO:0030276)
0.4 2.2 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 5.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 5.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.4 5.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 4.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.7 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 3.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 2.6 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 2.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 2.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.1 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 2.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 1.8 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.5 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.3 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 15.2 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.2 7.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 7.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 6.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 5.9 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 5.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 4.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 3.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.9 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0 2.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 2.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 2.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.0 REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR
0.0 2.0 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.2 1.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.6 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions