Motif ID: Fli1

Z-value: 1.387


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_325416020.104.8e-01Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 155 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_175491130 55.813 ENSMUST00000027812.5
 Rgs7
regulator of G protein signaling 7
chrX_-_136868537 30.346 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chr10_+_26229707 23.234 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr7_-_140082489 18.439 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr1_-_191318090 14.922 ENSMUST00000046770.9
 Nenf
neuron derived neurotrophic factor
chr11_+_32000452 12.277 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr11_+_32000496 11.373 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr8_+_23035116 11.087 ENSMUST00000117296.1
ENSMUST00000141784.2
 Ank1

ankyrin 1, erythroid

chr4_+_43406435 10.712 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr1_-_126492900 8.734 ENSMUST00000161954.1
 Nckap5
NCK-associated protein 5
chr8_+_23035099 8.589 ENSMUST00000117662.1
 Ank1
ankyrin 1, erythroid
chr5_+_117133567 7.666 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr2_+_65845833 7.584 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr16_-_42340595 7.576 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr6_-_77979515 7.501 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
 Ctnna2


catenin (cadherin associated protein), alpha 2


chr2_+_65845767 7.171 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr6_-_77979652 7.014 ENSMUST00000161846.1
ENSMUST00000160894.1
 Ctnna2

catenin (cadherin associated protein), alpha 2

chr13_+_118714678 6.113 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr17_+_79051906 5.764 ENSMUST00000040789.4
 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr9_+_74848437 5.604 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
 Gm16551


Gm20649
predicted gene 16551


predicted gene 20649

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 55.8 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
1.5 42.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 30.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.5 19.7 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 15.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.4 14.9 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
1.2 14.5 GO:0051823 radial glia guided migration of Purkinje cell(GO:0021942) regulation of synapse structural plasticity(GO:0051823)
1.3 13.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.3 9.5 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.4 7.7 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.8 7.6 GO:0016198 axon choice point recognition(GO:0016198)
0.8 7.1 GO:0009644 response to high light intensity(GO:0009644)
2.0 6.1 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
1.9 5.8 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 5.7 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
1.4 5.6 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 5.4 GO:0042391 regulation of membrane potential(GO:0042391)
0.2 5.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 4.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 4.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 55.8 GO:0044292 dendrite terminus(GO:0044292)
1.7 33.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 32.2 GO:0005768 endosome(GO:0005768)
0.5 30.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 14.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 7.8 GO:0005887 integral component of plasma membrane(GO:0005887)
1.3 7.6 GO:0044308 axonal spine(GO:0044308)
0.4 7.6 GO:0031527 filopodium membrane(GO:0031527)
0.0 6.8 GO:0009986 cell surface(GO:0009986)
0.1 5.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 5.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 5.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 4.8 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.1 4.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 4.4 GO:0045202 synapse(GO:0045202)
0.5 4.2 GO:0001520 outer dense fiber(GO:0001520)
0.1 4.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.5 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 63.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
5.3 42.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.5 31.1 GO:0019003 GDP binding(GO:0019003)
2.5 19.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 13.9 GO:0030507 spectrin binding(GO:0030507)
0.0 13.3 GO:0045296 cadherin binding(GO:0045296)
1.5 10.7 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 10.3 GO:0008083 growth factor activity(GO:0008083)
0.1 9.7 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 6.6 GO:0017137 Rab GTPase binding(GO:0017137)
1.5 6.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.4 5.8 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
1.9 5.6 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.1 5.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 5.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 5.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.4 4.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 4.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 4.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 4.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.3 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.2 7.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 7.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 6.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.4 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.2 3.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 3.3 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 2.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 2.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.0 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 55.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.9 33.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 9.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 7.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.5 6.1 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 6.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 5.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 4.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 4.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 3.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 3.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 3.1 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 3.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 2.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.9 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 1.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation