Motif ID: Fli1

Z-value: 1.387


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_325416020.104.8e-01Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_175491130 55.813 ENSMUST00000027812.5
Rgs7
regulator of G protein signaling 7
chrX_-_136868537 30.346 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr10_+_26229707 23.234 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr7_-_140082489 18.439 ENSMUST00000026541.7
Caly
calcyon neuron-specific vesicular protein
chr1_-_191318090 14.922 ENSMUST00000046770.9
Nenf
neuron derived neurotrophic factor
chr11_+_32000452 12.277 ENSMUST00000020537.2
ENSMUST00000109409.1
Nsg2

neuron specific gene family member 2

chr11_+_32000496 11.373 ENSMUST00000093219.3
Nsg2
neuron specific gene family member 2
chr8_+_23035116 11.087 ENSMUST00000117296.1
ENSMUST00000141784.2
Ank1

ankyrin 1, erythroid

chr4_+_43406435 10.712 ENSMUST00000098106.2
ENSMUST00000139198.1
Rusc2

RUN and SH3 domain containing 2

chr1_-_126492900 8.734 ENSMUST00000161954.1
Nckap5
NCK-associated protein 5
chr8_+_23035099 8.589 ENSMUST00000117662.1
Ank1
ankyrin 1, erythroid
chr5_+_117133567 7.666 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
Taok3


TAO kinase 3


chr2_+_65845833 7.584 ENSMUST00000053910.3
Csrnp3
cysteine-serine-rich nuclear protein 3
chr16_-_42340595 7.576 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr6_-_77979515 7.501 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
Ctnna2


catenin (cadherin associated protein), alpha 2


chr2_+_65845767 7.171 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr6_-_77979652 7.014 ENSMUST00000161846.1
ENSMUST00000160894.1
Ctnna2

catenin (cadherin associated protein), alpha 2

chr13_+_118714678 6.113 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr17_+_79051906 5.764 ENSMUST00000040789.4
Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr9_+_74848437 5.604 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chrX_+_123581700 5.112 ENSMUST00000178457.1
Gm6604
predicted gene 6604
chr11_-_100759740 5.091 ENSMUST00000107361.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chrX_-_72656135 5.000 ENSMUST00000055966.6
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chrX_+_123793665 4.857 ENSMUST00000178148.1
Gm5167
predicted gene 5167
chr6_-_120822680 4.771 ENSMUST00000019354.8
Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr11_-_100759942 4.607 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr7_+_3390629 4.523 ENSMUST00000182222.1
Cacng8
calcium channel, voltage-dependent, gamma subunit 8
chr1_+_182763961 4.337 ENSMUST00000153348.1
Susd4
sushi domain containing 4
chr13_+_42709482 4.304 ENSMUST00000066928.5
ENSMUST00000148891.1
Phactr1

phosphatase and actin regulator 1

chr11_-_68927049 4.240 ENSMUST00000038932.7
Odf4
outer dense fiber of sperm tails 4
chr17_-_53539411 4.153 ENSMUST00000056198.3
Pp2d1
protein phosphatase 2C-like domain containing 1
chr13_+_109260481 4.059 ENSMUST00000153234.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr5_-_36398090 4.036 ENSMUST00000037370.7
ENSMUST00000070720.6
Sorcs2

sortilin-related VPS10 domain containing receptor 2

chr10_+_69533761 4.019 ENSMUST00000182884.1
Ank3
ankyrin 3, epithelial
chr10_+_69533803 3.872 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
Ank3


ankyrin 3, epithelial


chr1_+_42952872 3.829 ENSMUST00000179766.1
Gpr45
G protein-coupled receptor 45
chr11_+_57011945 3.808 ENSMUST00000094179.4
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr11_+_57011798 3.750 ENSMUST00000036315.9
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr6_-_28831747 3.614 ENSMUST00000062304.5
Lrrc4
leucine rich repeat containing 4
chr15_-_76126538 3.574 ENSMUST00000054022.5
ENSMUST00000089654.3
BC024139

cDNA sequence BC024139

chr10_+_69534208 3.366 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
Ank3





ankyrin 3, epithelial





chr10_+_21993890 3.274 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chr9_+_111439063 3.226 ENSMUST00000111879.3
Dclk3
doublecortin-like kinase 3
chr7_-_4445595 3.133 ENSMUST00000119485.1
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr18_-_75697639 3.104 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr15_+_84167804 3.095 ENSMUST00000045289.4
Pnpla3
patatin-like phospholipase domain containing 3
chr7_+_24862193 3.030 ENSMUST00000052897.4
ENSMUST00000170837.2
Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr4_+_42655251 2.923 ENSMUST00000177785.1
Ccl27b
chemokine (C-C motif) ligand 27b
chr9_+_104569671 2.707 ENSMUST00000057742.8
Cpne4
copine IV
chr12_+_86678685 2.687 ENSMUST00000021681.3
Vash1
vasohibin 1
chr2_+_4017727 2.641 ENSMUST00000177457.1
Frmd4a
FERM domain containing 4A
chr15_-_76521902 2.623 ENSMUST00000164703.1
ENSMUST00000096365.3
Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr10_+_69534039 2.621 ENSMUST00000182557.1
Ank3
ankyrin 3, epithelial
chr9_+_104569754 2.595 ENSMUST00000077190.6
Cpne4
copine IV
chr14_+_76487759 2.571 ENSMUST00000142683.1
Tsc22d1
TSC22 domain family, member 1
chr4_+_42158092 2.543 ENSMUST00000098122.2
Gm13306
predicted gene 13306
chr5_-_73338580 2.464 ENSMUST00000087195.5
Ociad2
OCIA domain containing 2
chr15_-_97020322 2.246 ENSMUST00000166223.1
Slc38a4
solute carrier family 38, member 4
chr2_-_33086366 2.236 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr7_-_4445637 2.235 ENSMUST00000008579.7
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr10_-_127620960 2.213 ENSMUST00000121829.1
Lrp1
low density lipoprotein receptor-related protein 1
chr3_+_156562141 2.153 ENSMUST00000175773.1
Negr1
neuronal growth regulator 1
chr13_+_55464237 2.143 ENSMUST00000046533.7
Prr7
proline rich 7 (synaptic)
chr3_+_156561792 2.129 ENSMUST00000074015.4
Negr1
neuronal growth regulator 1
chr17_-_33358832 2.116 ENSMUST00000054072.8
Zfp81
zinc finger protein 81
chr5_-_120711927 2.099 ENSMUST00000031607.6
Dtx1
deltex 1 homolog (Drosophila)
chr17_+_8849974 2.042 ENSMUST00000115720.1
Pde10a
phosphodiesterase 10A
chr12_+_100199435 2.015 ENSMUST00000110082.3
Calm1
calmodulin 1
chr1_+_42953106 1.950 ENSMUST00000179655.1
Gpr45
G protein-coupled receptor 45
chr10_-_71285234 1.929 ENSMUST00000020085.6
Ube2d1
ubiquitin-conjugating enzyme E2D 1
chr17_-_24644933 1.901 ENSMUST00000019684.5
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr3_+_156561950 1.896 ENSMUST00000041425.5
ENSMUST00000106065.1
Negr1

neuronal growth regulator 1

chr18_+_61953048 1.895 ENSMUST00000051720.5
Sh3tc2
SH3 domain and tetratricopeptide repeats 2
chr10_-_127620922 1.857 ENSMUST00000118455.1
Lrp1
low density lipoprotein receptor-related protein 1
chr2_-_45112890 1.845 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr7_-_4445181 1.741 ENSMUST00000138798.1
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr3_-_122619442 1.711 ENSMUST00000162947.1
Fnbp1l
formin binding protein 1-like
chr15_-_98762992 1.706 ENSMUST00000156572.1
Arf3
ADP-ribosylation factor 3
chr6_+_4505493 1.700 ENSMUST00000031668.8
Col1a2
collagen, type I, alpha 2
chr15_-_98763195 1.669 ENSMUST00000053183.9
Arf3
ADP-ribosylation factor 3
chr13_+_83732438 1.640 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr5_-_106458440 1.545 ENSMUST00000086795.6
Barhl2
BarH-like 2 (Drosophila)
chr2_+_181520485 1.535 ENSMUST00000072334.5
Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr10_-_127621107 1.490 ENSMUST00000049149.8
Lrp1
low density lipoprotein receptor-related protein 1
chr2_-_45113255 1.483 ENSMUST00000068415.4
ENSMUST00000127520.1
Zeb2

zinc finger E-box binding homeobox 2

chrX_-_167209149 1.459 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr11_+_87595646 1.452 ENSMUST00000134216.1
Mtmr4
myotubularin related protein 4
chr9_+_70679016 1.431 ENSMUST00000144537.1
Adam10
a disintegrin and metallopeptidase domain 10
chr10_+_84917616 1.407 ENSMUST00000038523.7
ENSMUST00000095385.3
Ric8b

resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

chrX_-_8175890 1.387 ENSMUST00000143984.1
Tbc1d25
TBC1 domain family, member 25
chr11_-_5915124 1.365 ENSMUST00000109823.2
ENSMUST00000109822.1
Gck

glucokinase

chr2_+_91082362 1.308 ENSMUST00000169852.1
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_95076657 1.288 ENSMUST00000001548.7
Itga3
integrin alpha 3
chr6_+_145934113 1.246 ENSMUST00000032383.7
Sspn
sarcospan
chr4_+_109280266 1.111 ENSMUST00000102729.3
Eps15
epidermal growth factor receptor pathway substrate 15
chr5_+_123252087 1.085 ENSMUST00000121964.1
Wdr66
WD repeat domain 66
chr11_-_95076797 1.081 ENSMUST00000145671.1
ENSMUST00000120375.1
Itga3

integrin alpha 3

chr7_+_35186370 1.071 ENSMUST00000135452.1
ENSMUST00000001854.5
Slc7a10

solute carrier family 7 (cationic amino acid transporter, y+ system), member 10

chr11_+_17257558 1.063 ENSMUST00000000594.2
ENSMUST00000156784.1
C1d

C1D nuclear receptor co-repressor

chr17_+_48346465 1.036 ENSMUST00000113237.3
Trem2
triggering receptor expressed on myeloid cells 2
chr6_+_142414012 1.028 ENSMUST00000141548.1
B230216G23Rik
RIKEN cDNA B230216G23 gene
chr16_-_36666067 0.988 ENSMUST00000089620.4
Cd86
CD86 antigen
chr14_+_70077375 0.984 ENSMUST00000035908.1
Egr3
early growth response 3
chrX_+_109095359 0.935 ENSMUST00000033598.8
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr9_+_70678950 0.888 ENSMUST00000067880.6
Adam10
a disintegrin and metallopeptidase domain 10
chr4_+_40723084 0.878 ENSMUST00000149794.1
Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr17_+_48346401 0.812 ENSMUST00000024791.8
Trem2
triggering receptor expressed on myeloid cells 2
chr6_-_145250177 0.775 ENSMUST00000111710.1
ENSMUST00000155145.1
ENSMUST00000032399.5
Kras


v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog


chr2_+_121956411 0.773 ENSMUST00000110578.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr12_-_118301429 0.766 ENSMUST00000026367.9
Sp4
trans-acting transcription factor 4
chr17_+_6106880 0.753 ENSMUST00000149756.1
Tulp4
tubby like protein 4
chr3_-_30793549 0.746 ENSMUST00000180833.1
4933429H19Rik
RIKEN cDNA 4933429H19 gene
chr9_-_65021645 0.732 ENSMUST00000036615.5
Ptplad1
protein tyrosine phosphatase-like A domain containing 1
chr4_+_40722912 0.705 ENSMUST00000164233.1
ENSMUST00000137246.1
ENSMUST00000125442.1
Dnaja1


DnaJ (Hsp40) homolog, subfamily A, member 1


chr6_+_4504814 0.698 ENSMUST00000141483.1
Col1a2
collagen, type I, alpha 2
chr2_+_121956651 0.692 ENSMUST00000110574.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr4_+_148602527 0.691 ENSMUST00000105701.2
ENSMUST00000052060.6
Masp2

mannan-binding lectin serine peptidase 2

chr2_-_45113216 0.668 ENSMUST00000124942.1
Zeb2
zinc finger E-box binding homeobox 2
chr16_-_18289199 0.659 ENSMUST00000009321.4
ENSMUST00000115633.1
Dgcr8

DiGeorge syndrome critical region gene 8

chr5_-_135349991 0.657 ENSMUST00000044972.7
Fkbp6
FK506 binding protein 6
chr3_+_89136572 0.577 ENSMUST00000107482.3
ENSMUST00000127058.1
Pklr

pyruvate kinase liver and red blood cell

chr7_+_28440927 0.557 ENSMUST00000078845.6
Gmfg
glia maturation factor, gamma
chr2_-_119547627 0.529 ENSMUST00000060009.2
Exd1
exonuclease 3'-5' domain containing 1
chr19_+_8735808 0.487 ENSMUST00000049424.9
Wdr74
WD repeat domain 74
chr2_+_152962485 0.482 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr18_-_56975333 0.480 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik

RIKEN cDNA C330018D20 gene

chr6_+_29279587 0.463 ENSMUST00000167131.1
Fam71f2
family with sequence similarity 71, member F2
chr7_-_4996044 0.460 ENSMUST00000162502.1
Zfp579
zinc finger protein 579
chr18_+_65581704 0.449 ENSMUST00000182979.1
Zfp532
zinc finger protein 532
chr8_-_71486037 0.445 ENSMUST00000093450.4
Ano8
anoctamin 8
chr7_+_116093296 0.443 ENSMUST00000032899.5
1110004F10Rik
RIKEN cDNA 1110004F10 gene
chr5_+_127632238 0.411 ENSMUST00000118139.1
Glt1d1
glycosyltransferase 1 domain containing 1
chr12_-_75596195 0.373 ENSMUST00000021447.7
Ppp2r5e
protein phosphatase 2, regulatory subunit B (B56), epsilon isoform
chr19_-_8880883 0.357 ENSMUST00000096253.5
AI462493
expressed sequence AI462493
chr2_-_121037048 0.334 ENSMUST00000102490.3
Epb4.2
erythrocyte protein band 4.2
chr9_-_62811592 0.323 ENSMUST00000034775.8
Fem1b
feminization 1 homolog b (C. elegans)
chr2_+_121955964 0.314 ENSMUST00000036647.6
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr9_-_106789130 0.309 ENSMUST00000046502.5
Rad54l2
RAD54 like 2 (S. cerevisiae)
chr2_-_165287755 0.259 ENSMUST00000109298.1
ENSMUST00000109299.1
ENSMUST00000130393.1
ENSMUST00000017808.7
ENSMUST00000131409.1
ENSMUST00000156134.1
ENSMUST00000133961.1
Slc35c2






solute carrier family 35, member C2






chr8_-_106893515 0.246 ENSMUST00000176090.1
Chtf8
CTF8, chromosome transmission fidelity factor 8
chr7_-_4996095 0.237 ENSMUST00000108572.1
Zfp579
zinc finger protein 579
chr5_+_92137896 0.236 ENSMUST00000031355.6
Uso1
USO1 vesicle docking factor
chr11_-_79296906 0.225 ENSMUST00000068448.2
Gm9964
predicted gene 9964
chr2_+_119547697 0.205 ENSMUST00000014221.6
ENSMUST00000119172.1
Chp1

calcineurin-like EF hand protein 1

chr16_+_11066292 0.161 ENSMUST00000089011.4
Snn
stannin
chr5_-_134456702 0.160 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr4_+_147940859 0.159 ENSMUST00000103232.1
2510039O18Rik
RIKEN cDNA 2510039O18 gene
chr5_-_90366176 0.127 ENSMUST00000014421.8
ENSMUST00000081914.6
ENSMUST00000168058.2
Ankrd17


ankyrin repeat domain 17


chr3_+_122245557 0.111 ENSMUST00000029769.7
Gclm
glutamate-cysteine ligase, modifier subunit
chr8_+_106893616 0.111 ENSMUST00000047629.5
Cirh1a
cirrhosis, autosomal recessive 1A (human)
chr11_+_109362771 0.110 ENSMUST00000020930.7
ENSMUST00000106702.3
Gna13

guanine nucleotide binding protein, alpha 13

chr11_+_44519405 0.089 ENSMUST00000101327.2
Rnf145
ring finger protein 145
chr7_+_44428938 0.073 ENSMUST00000127790.1
Lrrc4b
leucine rich repeat containing 4B
chr11_-_74723829 0.034 ENSMUST00000102520.2
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr2_-_84650676 0.027 ENSMUST00000067232.3
Ctnnd1
catenin (cadherin associated protein), delta 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
1.9 5.8 GO:0018199 peptidyl-glutamine modification(GO:0018199)
1.5 42.1 GO:0048268 clathrin coat assembly(GO:0048268)
1.4 5.6 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
1.4 14.9 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
1.3 13.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.2 14.5 GO:0051823 radial glia guided migration of Purkinje cell(GO:0021942) regulation of synapse structural plasticity(GO:0051823)
1.1 4.3 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.8 7.6 GO:0016198 axon choice point recognition(GO:0016198)
0.8 7.1 GO:0009644 response to high light intensity(GO:0009644)
0.7 2.7 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.7 4.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.6 1.8 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
0.5 19.7 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.5 2.3 GO:0042117 monocyte activation(GO:0042117)
0.5 1.4 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.4 55.8 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.4 7.7 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.4 30.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.3 2.4 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.3 9.5 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.3 4.1 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 1.9 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.3 1.1 GO:0015825 L-serine transport(GO:0015825)
0.3 1.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.2 3.6 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.2 3.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.2 3.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.2 4.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.2 1.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 1.0 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.2 15.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 2.4 GO:0043589 skin morphogenesis(GO:0043589)
0.2 5.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 4.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 1.6 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.2 0.7 GO:0031053 primary miRNA processing(GO:0031053)
0.2 0.8 GO:2000774 positive regulation of Rac protein signal transduction(GO:0035022) positive regulation of cellular senescence(GO:2000774)
0.1 1.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 1.4 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.1 2.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.0 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 0.3 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.6 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 0.6 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1 3.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.8 GO:0008016 regulation of heart contraction(GO:0008016)
0.1 2.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 2.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 0.3 GO:0015786 UDP-glucose transport(GO:0015786)
0.1 2.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 2.6 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.1 GO:0039533 regulation of MDA-5 signaling pathway(GO:0039533)
0.0 4.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.5 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 2.0 GO:0043388 positive regulation of DNA binding(GO:0043388)
0.0 3.9 GO:0007631 feeding behavior(GO:0007631)
0.0 3.2 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.1 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.1 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 1.7 GO:0006914 autophagy(GO:0006914)
0.0 5.7 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 5.4 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 1.6 GO:0030516 regulation of axon extension(GO:0030516)
0.0 3.5 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 1.5 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 0.4 GO:0006821 chloride transport(GO:0006821)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 55.8 GO:0044292 dendrite terminus(GO:0044292)
1.7 33.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.3 7.6 GO:0044308 axonal spine(GO:0044308)
0.8 2.4 GO:0005584 collagen type I trimer(GO:0005584)
0.8 2.4 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.5 4.2 GO:0001520 outer dense fiber(GO:0001520)
0.5 30.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.4 7.6 GO:0031527 filopodium membrane(GO:0031527)
0.3 5.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 2.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.3 4.8 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.2 0.7 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.1 14.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 4.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 4.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.4 GO:0045180 basal cortex(GO:0045180)
0.1 5.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.9 GO:0032420 stereocilium(GO:0032420)
0.1 1.1 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 2.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 32.2 GO:0005768 endosome(GO:0005768)
0.0 2.5 GO:0005811 lipid particle(GO:0005811)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.1 GO:0097440 apical dendrite(GO:0097440)
0.0 2.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 5.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.0 GO:0043204 perikaryon(GO:0043204)
0.0 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.5 GO:0043195 terminal bouton(GO:0043195)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 7.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 6.8 GO:0009986 cell surface(GO:0009986)
0.0 4.4 GO:0045202 synapse(GO:0045202)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 42.1 GO:0032051 clathrin light chain binding(GO:0032051)
3.5 63.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
2.5 19.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.9 5.6 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
1.5 6.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
1.5 10.7 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.5 2.0 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.5 31.1 GO:0019003 GDP binding(GO:0019003)
0.5 1.8 GO:0070891 peptidoglycan binding(GO:0042834) lipoteichoic acid binding(GO:0070891)
0.4 5.8 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.4 3.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.4 4.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 2.0 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.3 5.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.3 13.9 GO:0030507 spectrin binding(GO:0030507)
0.2 1.4 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.2 5.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 1.3 GO:0051525 NFAT protein binding(GO:0051525)
0.2 1.6 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 0.6 GO:0004743 pyruvate kinase activity(GO:0004743)
0.2 2.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 4.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.7 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 9.7 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 4.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 4.0 GO:0070412 R-SMAD binding(GO:0070412)
0.1 10.3 GO:0008083 growth factor activity(GO:0008083)
0.1 2.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 1.5 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.1 5.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.4 GO:0043236 laminin binding(GO:0043236)
0.1 1.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.7 GO:0001846 opsonin binding(GO:0001846)
0.1 1.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 2.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.3 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 6.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 13.3 GO:0045296 cadherin binding(GO:0045296)
0.0 3.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 2.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 1.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.0 2.6 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.3 GO:0005123 death receptor binding(GO:0005123)
0.0 4.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 2.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0008408 3'-5' exonuclease activity(GO:0008408)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 3.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 6.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 7.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 8.3 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 2.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 4.4 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 3.3 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 2.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.0 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 33.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 6.1 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.4 55.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 7.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 5.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 9.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 1.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 4.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 3.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.2 2.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 6.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 3.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 0.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.9 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 2.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.0 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.8 REACTOME_SHC_MEDIATED_CASCADE Genes involved in SHC-mediated cascade
0.0 0.4 REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 3.1 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.7 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.1 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 1.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+