Motif ID: Fos

Z-value: 1.032


Transcription factors associated with Fos:

Gene SymbolEntrez IDGene Name
Fos ENSMUSG00000021250.7 Fos

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosmm10_v2_chr12_+_85473883_85473896-0.066.4e-01Click!


Activity profile for motif Fos.

activity profile for motif Fos


Sorted Z-values histogram for motif Fos

Sorted Z-values for motif Fos



Network of associatons between targets according to the STRING database.



First level regulatory network of Fos

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_13573927 20.981 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr2_+_20737306 15.930 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr18_+_82910863 15.392 ENSMUST00000171238.1
 Zfp516
zinc finger protein 516
chr13_+_15463837 14.118 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr7_+_19083842 10.960 ENSMUST00000032568.7
ENSMUST00000122999.1
ENSMUST00000108473.3
ENSMUST00000108474.1
 Dmpk



dystrophia myotonica-protein kinase



chr10_-_42583628 9.875 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr17_+_35049966 9.459 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr8_-_61591130 9.281 ENSMUST00000135439.1
ENSMUST00000121200.1
 Palld

palladin, cytoskeletal associated protein

chr2_+_30078584 9.038 ENSMUST00000045246.7
 Pkn3
protein kinase N3
chr7_+_27486910 8.252 ENSMUST00000008528.7
 Sertad1
SERTA domain containing 1
chr10_+_88091070 8.250 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr18_+_35118880 8.212 ENSMUST00000042345.6
 Ctnna1
catenin (cadherin associated protein), alpha 1
chr19_+_36409719 7.874 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr6_+_53573364 7.483 ENSMUST00000047450.7
 Creb5
cAMP responsive element binding protein 5
chr7_-_126799163 7.366 ENSMUST00000032934.5
 Aldoa
aldolase A, fructose-bisphosphate
chr16_-_44558864 7.227 ENSMUST00000023370.4
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr17_+_78508063 7.185 ENSMUST00000024880.9
 Vit
vitrin
chr11_-_84067063 7.123 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr7_-_126799134 6.826 ENSMUST00000087566.4
 Aldoa
aldolase A, fructose-bisphosphate
chr8_+_94984399 6.802 ENSMUST00000093271.6
 Gpr56
G protein-coupled receptor 56

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 21.0 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.5 18.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.5 15.6 GO:0050873 brown fat cell differentiation(GO:0050873)
1.4 14.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
4.7 14.1 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.5 13.8 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 12.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
2.6 10.5 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
2.0 9.9 GO:0021764 amygdala development(GO:0021764)
0.5 9.5 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.5 8.7 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
1.4 8.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
2.7 8.2 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
2.1 8.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 7.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.3 7.6 GO:0043486 histone exchange(GO:0043486)
0.0 7.2 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.3 6.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 6.8 GO:0000910 cytokinesis(GO:0000910)
0.0 6.8 GO:0045444 fat cell differentiation(GO:0045444)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 23.5 GO:0044295 axonal growth cone(GO:0044295)
5.2 21.0 GO:0045098 type III intermediate filament(GO:0045098)
1.0 14.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 13.5 GO:0016592 mediator complex(GO:0016592)
0.3 12.0 GO:0034707 chloride channel complex(GO:0034707)
0.5 10.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 8.9 GO:0005925 focal adhesion(GO:0005925)
0.7 8.2 GO:0005915 zonula adherens(GO:0005915)
0.1 7.9 GO:0031519 PcG protein complex(GO:0031519)
0.1 7.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.4 7.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 7.0 GO:0005913 cell-cell adherens junction(GO:0005913)
2.2 6.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.3 6.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 6.1 GO:0030496 midbody(GO:0030496)
0.0 5.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 4.0 GO:0005802 trans-Golgi network(GO:0005802)
0.6 3.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.3 3.9 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 21.9 GO:0019208 phosphatase regulator activity(GO:0019208)
5.4 21.8 GO:1990254 keratin filament binding(GO:1990254)
0.4 19.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.2 18.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 14.8 GO:0033613 activating transcription factor binding(GO:0033613)
2.4 14.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 13.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.7 13.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 11.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.6 11.0 GO:0017166 vinculin binding(GO:0017166)
0.1 9.9 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 9.1 GO:0015108 chloride transmembrane transporter activity(GO:0015108)
0.4 9.0 GO:0004697 protein kinase C activity(GO:0004697)
1.4 8.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.5 8.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 7.9 GO:0035497 cAMP response element binding(GO:0035497)
0.2 7.9 GO:0001671 ATPase activator activity(GO:0001671)
1.6 6.6 GO:0050436 microfibril binding(GO:0050436)
0.5 5.9 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.3 5.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 26.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 21.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 15.2 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 14.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 14.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.4 13.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 13.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 6.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 5.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 5.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 4.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 4.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 3.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 3.3 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 2.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 2.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 2.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 1.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 29.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.9 21.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 9.8 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 9.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.4 6.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 6.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 5.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 5.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.8 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.2 4.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.6 4.4 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 3.9 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 3.4 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.2 3.3 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 2.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 2.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.2 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.3 2.1 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.9 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling