Motif ID: Fosl2_Bach2

Z-value: 0.725

Transcription factors associated with Fosl2_Bach2:

Gene SymbolEntrez IDGene Name
Bach2 ENSMUSG00000040270.10 Bach2
Fosl2 ENSMUSG00000029135.9 Fosl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl2mm10_v2_chr5_+_32136458_321365050.801.6e-13Click!
Bach2mm10_v2_chr4_+_32238950_322389640.431.1e-03Click!


Activity profile for motif Fosl2_Bach2.

activity profile for motif Fosl2_Bach2


Sorted Z-values histogram for motif Fosl2_Bach2

Sorted Z-values for motif Fosl2_Bach2



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosl2_Bach2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 12.690 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr6_+_17463927 8.167 ENSMUST00000115442.1
 Met
met proto-oncogene
chr18_+_32938955 6.204 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr3_+_55461758 5.358 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr9_-_20728219 5.279 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr14_+_65968483 5.189 ENSMUST00000022616.6
 Clu
clusterin
chr6_-_124769548 5.072 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr2_+_156475803 4.917 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr8_+_95703037 4.780 ENSMUST00000073139.7
ENSMUST00000080666.7
 Ndrg4

N-myc downstream regulated gene 4

chr2_+_156475844 4.744 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr9_+_60712989 4.648 ENSMUST00000038407.5
 Larp6
La ribonucleoprotein domain family, member 6
chr2_-_151632471 4.464 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr2_-_45110241 4.428 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr14_+_27622433 4.408 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr14_+_101840602 4.331 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr10_-_64090241 4.229 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr14_+_101840501 3.990 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr3_-_88503187 3.941 ENSMUST00000120377.1
 Lmna
lamin A
chr3_-_88503331 3.819 ENSMUST00000029699.6
 Lmna
lamin A
chrY_-_1286563 3.743 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.9 13.1 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.3 12.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 8.9 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
1.6 7.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.6 6.9 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
1.0 6.2 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.5 6.0 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.4 5.7 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 5.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.4 4.8 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.9 4.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.0 4.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 4.1 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.5 3.6 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 3.4 GO:0006417 regulation of translation(GO:0006417)
1.1 3.3 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.2 3.3 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.3 3.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 3.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.4 GO:0009925 basal plasma membrane(GO:0009925)
0.1 12.6 GO:0001650 fibrillar center(GO:0001650)
0.1 10.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 10.1 GO:0016324 apical plasma membrane(GO:0016324)
0.0 9.3 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
1.1 7.8 GO:0005638 lamin filament(GO:0005638)
0.1 7.6 GO:0055037 recycling endosome(GO:0055037)
0.7 7.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 7.1 GO:0014069 postsynaptic density(GO:0014069)
0.1 6.7 GO:0005604 basement membrane(GO:0005604)
0.1 5.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 5.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.6 5.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 5.1 GO:0031985 Golgi cisterna(GO:0031985)
0.2 4.7 GO:0032279 asymmetric synapse(GO:0032279)
0.3 4.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 3.9 GO:0031253 cell projection membrane(GO:0031253)
0.9 3.6 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 3.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 3.2 GO:0016461 unconventional myosin complex(GO:0016461)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 13.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 12.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 10.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 8.3 GO:0042805 actinin binding(GO:0042805)
0.3 7.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 7.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.6 7.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 6.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 6.6 GO:0005543 phospholipid binding(GO:0005543)
0.5 6.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.6 5.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 5.1 GO:0070412 R-SMAD binding(GO:0070412)
0.2 5.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 5.0 GO:0008017 microtubule binding(GO:0008017)
0.3 4.9 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 4.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 4.2 GO:0030165 PDZ domain binding(GO:0030165)
0.2 4.1 GO:0070064 proline-rich region binding(GO:0070064)
0.6 3.6 GO:0005042 netrin receptor activity(GO:0005042)
0.1 3.4 GO:0005518 collagen binding(GO:0005518)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.2 PID_ARF6_PATHWAY Arf6 signaling events
0.1 8.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 7.2 PID_ARF_3PATHWAY Arf1 pathway
0.1 6.7 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 6.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 3.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.9 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 2.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 2.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 2.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 2.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 1.9 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.4 7.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 6.4 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 6.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 4.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 3.6 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 3.5 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.3 3.3 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.9 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.7 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 2.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 2.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 2.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 2.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.2 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.1 2.1 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 2.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides