Motif ID: Foxa2_Foxa1

Z-value: 1.664

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa1mm10_v2_chr12_-_57546121_575461410.366.2e-03Click!
Foxa2mm10_v2_chr2_-_148045891_1480459480.358.5e-03Click!


Activity profile for motif Foxa2_Foxa1.

activity profile for motif Foxa2_Foxa1


Sorted Z-values histogram for motif Foxa2_Foxa1

Sorted Z-values for motif Foxa2_Foxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_84086379 25.586 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr17_-_70851710 25.060 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr14_+_73237891 24.988 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr13_-_60177357 21.461 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr4_-_58499398 21.325 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr2_+_25180737 19.981 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr1_-_138619687 15.894 ENSMUST00000027642.2
 Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr12_-_99883429 14.515 ENSMUST00000046485.3
 Efcab11
EF-hand calcium binding domain 11
chr18_-_62756275 14.281 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr14_+_13454010 13.964 ENSMUST00000112656.2
 Synpr
synaptoporin
chr4_+_11191726 13.784 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr10_-_93311073 13.708 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr14_-_48662740 13.307 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr7_+_67655414 13.206 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr10_-_93310963 12.568 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr17_+_29090969 12.375 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_+_181767283 12.175 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr2_+_181767040 12.141 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr12_-_56535047 12.106 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr10_-_128180265 11.491 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 32.9 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
1.8 29.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 28.2 GO:0006270 DNA replication initiation(GO:0006270)
2.4 26.8 GO:0060539 diaphragm development(GO:0060539)
8.5 25.6 GO:0060023 soft palate development(GO:0060023)
0.5 24.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 22.1 GO:0042060 wound healing(GO:0042060)
2.0 21.5 GO:0042473 outer ear morphogenesis(GO:0042473)
5.3 21.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.8 20.0 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.4 19.4 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
1.6 19.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.6 16.4 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.8 15.9 GO:1904355 positive regulation of telomere capping(GO:1904355)
5.3 15.8 GO:0021759 globus pallidus development(GO:0021759)
3.3 13.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.4 12.5 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
1.5 12.4 GO:0071493 cellular response to UV-B(GO:0071493)
1.2 12.0 GO:0071763 nuclear membrane organization(GO:0071763)
3.7 11.1 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 36.7 GO:0005654 nucleoplasm(GO:0005654)
7.8 23.4 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 21.3 GO:0043198 dendritic shaft(GO:0043198)
0.9 21.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.6 20.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
2.2 19.4 GO:0030478 actin cap(GO:0030478)
0.0 19.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 17.7 GO:0016607 nuclear speck(GO:0016607)
1.6 17.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 14.6 GO:0005615 extracellular space(GO:0005615)
0.1 14.0 GO:0031225 anchored component of membrane(GO:0031225)
4.1 12.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 12.3 GO:0031965 nuclear membrane(GO:0031965)
2.2 10.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
1.3 10.3 GO:0033269 internode region of axon(GO:0033269)
0.1 8.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 8.6 GO:0005876 spindle microtubule(GO:0005876)
0.2 7.4 GO:0030904 retromer complex(GO:0030904)
1.8 7.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.4 7.2 GO:0035189 Rb-E2F complex(GO:0035189)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 63.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
7.5 52.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
6.6 26.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.1 25.1 GO:0070410 co-SMAD binding(GO:0070410)
0.7 23.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 20.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
1.4 16.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 12.9 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
4.1 12.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.5 12.0 GO:0005521 lamin binding(GO:0005521)
0.6 11.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
3.7 11.1 GO:0016015 morphogen activity(GO:0016015)
0.2 10.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 10.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 9.3 GO:0051015 actin filament binding(GO:0051015)
0.3 9.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.8 8.5 GO:0070700 BMP receptor binding(GO:0070700)
0.2 7.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.4 7.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
2.4 7.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 30.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 29.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 24.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.7 22.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 21.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 16.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 14.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 12.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.4 12.5 PID_MYC_PATHWAY C-MYC pathway
1.5 12.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.3 10.3 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.3 9.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.8 8.5 PID_ALK2_PATHWAY ALK2 signaling events
0.2 8.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 7.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 5.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 5.5 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 4.8 PID_ATR_PATHWAY ATR signaling pathway
0.1 4.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 3.9 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 31.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
1.2 30.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 27.4 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.7 25.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.7 22.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.5 19.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 16.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 11.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 10.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.7 10.4 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.9 9.6 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.5 8.2 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.3 8.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 7.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 6.1 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.4 5.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 5.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 5.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 4.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 4.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling