Motif ID: Foxa2_Foxa1
Z-value: 1.664
Transcription factors associated with Foxa2_Foxa1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxa1 | ENSMUSG00000035451.6 | Foxa1 |
| Foxa2 | ENSMUSG00000037025.5 | Foxa2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxa1 | mm10_v2_chr12_-_57546121_57546141 | 0.36 | 6.2e-03 | Click! |
| Foxa2 | mm10_v2_chr2_-_148045891_148045948 | 0.35 | 8.5e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 25.6 | GO:0060023 | soft palate development(GO:0060023) |
| 5.3 | 21.3 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 5.3 | 15.8 | GO:0021759 | globus pallidus development(GO:0021759) |
| 3.7 | 11.1 | GO:1902524 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 3.7 | 11.1 | GO:1900108 | negative regulation of nodal signaling pathway(GO:1900108) |
| 3.3 | 13.3 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 2.8 | 8.5 | GO:0072076 | hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 2.5 | 7.5 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 2.4 | 26.8 | GO:0060539 | diaphragm development(GO:0060539) |
| 2.4 | 4.9 | GO:0072095 | regulation of branch elongation involved in ureteric bud branching(GO:0072095) |
| 2.4 | 7.2 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 2.3 | 7.0 | GO:0097402 | neuroblast migration(GO:0097402) |
| 2.0 | 21.5 | GO:0042473 | outer ear morphogenesis(GO:0042473) |
| 1.8 | 29.3 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 1.8 | 32.9 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 1.8 | 20.0 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 1.8 | 7.2 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 1.7 | 10.3 | GO:0003383 | apical constriction(GO:0003383) |
| 1.6 | 16.4 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 1.6 | 3.2 | GO:0002572 | pro-T cell differentiation(GO:0002572) |
| 1.6 | 4.8 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
| 1.6 | 19.0 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 1.5 | 12.4 | GO:0071493 | cellular response to UV-B(GO:0071493) |
| 1.5 | 4.5 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 1.5 | 7.4 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 1.4 | 12.5 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 1.4 | 5.5 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) |
| 1.4 | 8.2 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 1.3 | 3.9 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 1.3 | 3.8 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
| 1.2 | 9.6 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) anterior/posterior axon guidance(GO:0033564) |
| 1.2 | 12.0 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 1.2 | 5.8 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 1.1 | 4.2 | GO:0060686 | negative regulation of prostatic bud formation(GO:0060686) |
| 1.0 | 10.9 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.9 | 9.2 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
| 0.9 | 7.1 | GO:0015074 | DNA integration(GO:0015074) |
| 0.8 | 2.5 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.8 | 4.1 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
| 0.8 | 10.4 | GO:0072189 | ureter development(GO:0072189) |
| 0.8 | 3.9 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.8 | 15.9 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.7 | 28.2 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.7 | 7.4 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.7 | 2.0 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
| 0.7 | 2.6 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.6 | 4.4 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366) |
| 0.6 | 7.1 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.6 | 5.9 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.6 | 3.0 | GO:0015817 | glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365) |
| 0.6 | 3.5 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.6 | 1.7 | GO:0016332 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) |
| 0.6 | 6.1 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.5 | 1.1 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
| 0.5 | 2.7 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.5 | 24.4 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.5 | 0.9 | GO:0014834 | ectoderm formation(GO:0001705) skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834) |
| 0.5 | 2.8 | GO:0021830 | interneuron migration from the subpallium to the cortex(GO:0021830) |
| 0.5 | 3.3 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.4 | 1.3 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 0.4 | 2.2 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994) |
| 0.4 | 0.9 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 0.4 | 3.7 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.4 | 2.4 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.4 | 0.4 | GO:0060681 | branch elongation involved in ureteric bud branching(GO:0060681) |
| 0.4 | 3.1 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.4 | 2.3 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.4 | 4.9 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.4 | 1.9 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.4 | 4.4 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.4 | 19.4 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.3 | 2.0 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.3 | 1.0 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.3 | 1.0 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.3 | 1.2 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 0.3 | 3.0 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.3 | 1.8 | GO:1901072 | glucosamine-containing compound catabolic process(GO:1901072) |
| 0.3 | 0.9 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.2 | 7.9 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.2 | 6.2 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.2 | 1.2 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.2 | 3.9 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.2 | 1.8 | GO:0021559 | trigeminal nerve development(GO:0021559) |
| 0.2 | 2.5 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.2 | 5.2 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.2 | 0.8 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.2 | 0.4 | GO:0060528 | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528) |
| 0.2 | 1.0 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.2 | 0.6 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.2 | 1.2 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.2 | 2.7 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.2 | 3.6 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.2 | 7.4 | GO:0050982 | detection of mechanical stimulus(GO:0050982) |
| 0.2 | 1.9 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.2 | 0.7 | GO:0001865 | NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) |
| 0.2 | 0.6 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.1 | 0.6 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.1 | 0.8 | GO:0021937 | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) |
| 0.1 | 3.7 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.1 | 4.5 | GO:0035411 | catenin import into nucleus(GO:0035411) |
| 0.1 | 1.2 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.1 | 1.7 | GO:0060746 | parental behavior(GO:0060746) |
| 0.1 | 5.4 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.1 | 0.6 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.1 | 4.7 | GO:0002011 | morphogenesis of an epithelial sheet(GO:0002011) |
| 0.1 | 1.2 | GO:0017144 | drug metabolic process(GO:0017144) |
| 0.1 | 22.1 | GO:0042060 | wound healing(GO:0042060) |
| 0.1 | 1.2 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 1.1 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.1 | 1.9 | GO:0006625 | protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 4.5 | GO:0050868 | negative regulation of T cell activation(GO:0050868) |
| 0.1 | 8.0 | GO:0007098 | centrosome cycle(GO:0007098) |
| 0.1 | 1.7 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.1 | 0.4 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.1 | 1.3 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.1 | 0.5 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.1 | 0.5 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 0.9 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.1 | 5.4 | GO:0030326 | embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113) |
| 0.1 | 0.8 | GO:0060972 | left/right pattern formation(GO:0060972) |
| 0.0 | 0.7 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 1.2 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 1.4 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 0.3 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 1.1 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.0 | 1.7 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.0 | 0.6 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.0 | 0.3 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
| 0.0 | 1.2 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.0 | 1.5 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.0 | 0.6 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.6 | GO:1903846 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.0 | 1.0 | GO:0002224 | toll-like receptor signaling pathway(GO:0002224) |
| 0.0 | 2.8 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 1.1 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 0.5 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731) |
| 0.0 | 0.3 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
| 0.0 | 0.7 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.0 | 0.5 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.5 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 2.5 | GO:0006814 | sodium ion transport(GO:0006814) |
| 0.0 | 0.6 | GO:0032755 | positive regulation of interleukin-6 production(GO:0032755) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.8 | 23.4 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 4.1 | 12.4 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 2.2 | 10.9 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 2.2 | 19.4 | GO:0030478 | actin cap(GO:0030478) |
| 1.8 | 7.2 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 1.6 | 17.3 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 1.4 | 7.2 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 1.3 | 10.3 | GO:0033269 | internode region of axon(GO:0033269) |
| 1.0 | 5.9 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.9 | 21.2 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.8 | 5.8 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.7 | 7.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.6 | 20.3 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.5 | 2.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.3 | 4.8 | GO:0042555 | MCM complex(GO:0042555) |
| 0.3 | 3.5 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.3 | 1.9 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.2 | 1.2 | GO:1990357 | terminal web(GO:1990357) |
| 0.2 | 7.4 | GO:0030904 | retromer complex(GO:0030904) |
| 0.2 | 0.6 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.2 | 2.4 | GO:0043034 | costamere(GO:0043034) |
| 0.2 | 21.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.2 | 3.1 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.2 | 0.8 | GO:0001652 | granular component(GO:0001652) |
| 0.2 | 8.6 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.2 | 6.4 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.1 | 14.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 3.0 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.7 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.1 | 2.4 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.1 | 3.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 8.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 7.1 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 4.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 6.4 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 4.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 0.3 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.1 | 6.8 | GO:0030496 | midbody(GO:0030496) |
| 0.1 | 1.5 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 2.1 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 0.8 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.1 | 17.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 12.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 19.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 1.1 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 0.8 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 2.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 1.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.6 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 1.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.9 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.9 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 0.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.6 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 36.7 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 14.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 2.6 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 2.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 0.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.2 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.0 | 0.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.6 | GO:0000922 | spindle pole(GO:0000922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 52.8 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 6.6 | 26.3 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 4.1 | 12.4 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 3.7 | 11.1 | GO:0016015 | morphogen activity(GO:0016015) |
| 2.4 | 7.1 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 1.4 | 7.2 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 1.4 | 16.6 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 1.3 | 3.9 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 1.1 | 25.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 1.0 | 5.9 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 1.0 | 3.0 | GO:0015182 | L-asparagine transmembrane transporter activity(GO:0015182) |
| 0.8 | 8.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.8 | 4.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.8 | 4.8 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.8 | 3.8 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.7 | 23.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.6 | 2.4 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 0.6 | 11.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.5 | 3.8 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.5 | 2.6 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.5 | 12.0 | GO:0005521 | lamin binding(GO:0005521) |
| 0.4 | 1.3 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.4 | 6.5 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.4 | 1.2 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.4 | 3.1 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.4 | 7.0 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.3 | 63.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 0.9 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.3 | 9.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.3 | 7.0 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.3 | 5.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 2.0 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.2 | 3.6 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.2 | 10.3 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.2 | 4.7 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.2 | 2.5 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.2 | 2.5 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.2 | 1.0 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.2 | 2.7 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.2 | 20.8 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.2 | 0.5 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.2 | 2.5 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.2 | 0.5 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.2 | 7.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 2.5 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.1 | 3.2 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 4.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 2.5 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 4.7 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 2.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 5.5 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.1 | 2.8 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 1.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 1.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 1.2 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.1 | 0.6 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.1 | 0.6 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 6.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 1.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 1.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 1.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 2.2 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 1.9 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 2.0 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 0.5 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.1 | 1.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 6.2 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.1 | 5.3 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.1 | 2.8 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.1 | 1.1 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 12.9 | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) |
| 0.0 | 9.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 1.1 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 10.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 1.2 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.4 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 1.8 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 4.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.1 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.0 | 0.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.9 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 2.5 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.3 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 1.9 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 4.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 1.4 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.8 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.5 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.6 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 0.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 5.2 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 1.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 30.6 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 1.5 | 12.4 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.8 | 8.5 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.7 | 22.9 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.4 | 5.5 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.4 | 12.5 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.4 | 16.2 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 12.6 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 29.9 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 7.4 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.3 | 24.0 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.3 | 9.6 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.3 | 10.3 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.2 | 3.7 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 21.1 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 8.5 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.2 | 2.8 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.2 | 2.0 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.2 | 3.9 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 0.2 | 5.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.2 | 3.9 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.6 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 2.4 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 4.8 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.1 | 1.3 | PID_S1P_S1P3_PATHWAY | S1P3 pathway |
| 0.1 | 1.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.1 | 14.8 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.3 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.1 | 2.2 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 0.7 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.1 | 1.0 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 1.2 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 3.0 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 4.0 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.2 | PID_E2F_PATHWAY | E2F transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 31.5 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 1.2 | 30.6 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.9 | 9.6 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.7 | 25.1 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.7 | 22.5 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.7 | 10.4 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.5 | 19.3 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.5 | 8.2 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.5 | 2.8 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.4 | 3.0 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.4 | 5.9 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.4 | 11.1 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.4 | 6.1 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.3 | 16.6 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 4.8 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.3 | 8.0 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.3 | 3.9 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.2 | 5.6 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.2 | 5.2 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.2 | 1.2 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 27.4 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.2 | 4.5 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.2 | 1.5 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 0.9 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.1 | 1.1 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.1 | 3.6 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 1.6 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 3.2 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 7.9 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 3.6 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 0.7 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 1.6 | REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK | Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK |
| 0.1 | 1.3 | REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.1 | 0.5 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.0 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 2.3 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.0 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 10.8 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 2.4 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.1 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.4 | REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 3.5 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.7 | REACTOME_CELL_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.0 | 0.9 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.1 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 2.2 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
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