Motif ID: Foxa3

Z-value: 0.963


Transcription factors associated with Foxa3:

Gene SymbolEntrez IDGene Name
Foxa3 ENSMUSG00000040891.5 Foxa3



Activity profile for motif Foxa3.

activity profile for motif Foxa3


Sorted Z-values histogram for motif Foxa3

Sorted Z-values for motif Foxa3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa3

PNG image of the network

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Top targets:


Showing 1 to 20 of 165 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103813913 10.748 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr9_+_53850243 9.141 ENSMUST00000048485.5
 Sln
sarcolipin
chr15_+_3270767 8.368 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr7_-_103827922 7.634 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr10_+_60106452 7.232 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr1_+_17145357 6.527 ENSMUST00000026879.7
 Gdap1
ganglioside-induced differentiation-associated-protein 1
chr8_-_84773381 6.462 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr2_-_77519565 5.639 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr1_+_51289106 5.503 ENSMUST00000051572.6
 Sdpr
serum deprivation response
chr9_-_112187898 4.754 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr11_+_78499087 4.648 ENSMUST00000017488.4
 Vtn
vitronectin
chr13_+_94173992 4.648 ENSMUST00000121618.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr16_+_91269759 4.494 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr13_+_16011851 4.399 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr7_-_27181149 4.369 ENSMUST00000071986.6
ENSMUST00000121848.1
 Mia

melanoma inhibitory activity

chr18_+_67133713 4.262 ENSMUST00000076605.7
 Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr17_+_70522083 4.078 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr4_+_42922253 4.015 ENSMUST00000139100.1
 N28178
expressed sequence N28178
chr9_-_112187766 3.909 ENSMUST00000111872.2
ENSMUST00000164754.2
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr4_-_116405986 3.833 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 9.1 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.2 8.7 GO:0034605 cellular response to heat(GO:0034605)
0.9 7.9 GO:0071420 cellular response to histamine(GO:0071420)
0.8 7.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.5 7.1 GO:0070842 aggresome assembly(GO:0070842)
0.4 6.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 6.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.8 5.8 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.3 5.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.7 4.9 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 4.7 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.4 4.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302) liver regeneration(GO:0097421)
0.0 4.6 GO:0048813 dendrite morphogenesis(GO:0048813)
0.9 4.4 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.7 4.3 GO:0009405 pathogenesis(GO:0009405)
0.0 4.1 GO:0007160 cell-matrix adhesion(GO:0007160)
1.3 3.9 GO:0048014 Tie signaling pathway(GO:0048014)
1.0 3.8 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.5 3.8 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.3 3.8 GO:0021527 spinal cord association neuron differentiation(GO:0021527)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 18.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 9.7 GO:0001650 fibrillar center(GO:0001650)
0.5 9.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.5 7.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 7.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 6.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 5.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 5.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.9 4.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.5 4.4 GO:0043512 inhibin A complex(GO:0043512)
0.1 4.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.9 GO:0005902 microvillus(GO:0005902)
0.0 3.8 GO:0031252 cell leading edge(GO:0031252)
0.1 3.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.6 GO:0071564 npBAF complex(GO:0071564)
0.0 3.6 GO:0016607 nuclear speck(GO:0016607)
0.4 3.5 GO:0097433 dense body(GO:0097433)
0.0 3.4 GO:0043204 perikaryon(GO:0043204)
0.1 3.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 18.4 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.4 7.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 7.8 GO:0005516 calmodulin binding(GO:0005516)
0.1 7.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 7.0 GO:0008017 microtubule binding(GO:0008017)
0.2 6.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 6.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 5.1 GO:0002039 p53 binding(GO:0002039)
1.2 4.9 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.3 4.6 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 4.5 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.7 4.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 4.4 GO:0008083 growth factor activity(GO:0008083)
0.2 4.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 4.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 3.8 GO:0019213 deacetylase activity(GO:0019213)
0.1 3.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.5 3.5 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.8 3.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 3.1 GO:0051059 NF-kappaB binding(GO:0051059)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 PID_SHP2_PATHWAY SHP2 signaling
0.2 7.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 4.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 4.4 PID_ALK1_PATHWAY ALK1 signaling events
0.3 4.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.4 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 2.8 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 2.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.3 2.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 1.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.6 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 1.4 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 1.3 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 1.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 7.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 6.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
1.1 4.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.9 4.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 4.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.2 3.4 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 2.8 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.1 2.5 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.3 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 1.6 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 1.5 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.4 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.2 1.0 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 0.9 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 0.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators