Motif ID: Foxc1
Z-value: 0.767

Transcription factors associated with Foxc1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Foxc1 | ENSMUSG00000050295.2 | Foxc1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Foxc1 | mm10_v2_chr13_+_31806627_31806650 | 0.08 | 5.5e-01 | Click! |
Top targets:
Showing 1 to 20 of 172 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 77 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 5.3 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
0.0 | 4.8 | GO:0006413 | translational initiation(GO:0006413) |
1.0 | 3.8 | GO:0071105 | response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105) |
0.2 | 3.0 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
0.6 | 2.9 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
0.4 | 2.8 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
0.2 | 2.8 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
0.5 | 2.7 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
0.1 | 2.7 | GO:0042417 | dopamine metabolic process(GO:0042417) |
0.0 | 2.5 | GO:0006836 | neurotransmitter transport(GO:0006836) |
0.6 | 2.2 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
0.1 | 1.9 | GO:0034390 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
0.1 | 1.8 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.0 | 1.8 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) |
0.5 | 1.5 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) positive regulation of dendritic cell chemotaxis(GO:2000510) |
0.0 | 1.5 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
0.0 | 1.5 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
0.5 | 1.4 | GO:0036118 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
0.1 | 1.4 | GO:0045671 | negative regulation of osteoclast differentiation(GO:0045671) |
0.1 | 1.4 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 42 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 13.7 | GO:0005615 | extracellular space(GO:0005615) |
0.0 | 4.4 | GO:0016234 | inclusion body(GO:0016234) |
0.2 | 2.9 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.2 | 2.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
0.0 | 2.5 | GO:0043195 | terminal bouton(GO:0043195) |
0.1 | 1.9 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
0.0 | 1.5 | GO:0032420 | stereocilium(GO:0032420) |
0.4 | 1.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
0.1 | 1.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 1.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 1.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.0 | 1.2 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.2 | 1.1 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
0.1 | 1.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
0.0 | 1.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.3 | 1.0 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
0.3 | 1.0 | GO:0042585 | germinal vesicle(GO:0042585) |
0.1 | 1.0 | GO:0042101 | T cell receptor complex(GO:0042101) |
0.1 | 0.9 | GO:0005865 | striated muscle thin filament(GO:0005865) |
0.2 | 0.8 | GO:1990590 | ATF1-ATF4 transcription factor complex(GO:1990590) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 63 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 5.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.1 | 4.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
0.3 | 3.8 | GO:0050693 | LBD domain binding(GO:0050693) |
0.0 | 3.8 | GO:0002020 | protease binding(GO:0002020) |
0.2 | 2.9 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.7 | 2.8 | GO:0008142 | oxysterol binding(GO:0008142) |
0.4 | 2.8 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.3 | 2.3 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
0.0 | 2.3 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
0.3 | 2.0 | GO:1903136 | cuprous ion binding(GO:1903136) |
0.3 | 1.9 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
0.2 | 1.8 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.1 | 1.8 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.0 | 1.8 | GO:0008083 | growth factor activity(GO:0008083) |
0.2 | 1.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
0.1 | 1.5 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
0.0 | 1.5 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
0.5 | 1.4 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.2 | 1.3 | GO:0045340 | mercury ion binding(GO:0045340) |
0.1 | 1.3 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
Gene overrepresentation in C2:CP category:
Showing 1 to 19 of 19 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 5.7 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
0.0 | 5.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.1 | 4.8 | PID_INTEGRIN1_PATHWAY | Beta1 integrin cell surface interactions |
0.0 | 4.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 1.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.0 | 1.1 | PID_BMP_PATHWAY | BMP receptor signaling |
0.0 | 1.0 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.0 | 1.0 | PID_AURORA_A_PATHWAY | Aurora A signaling |
0.0 | 1.0 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.0 | 1.0 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
0.1 | 0.8 | PID_ALK2_PATHWAY | ALK2 signaling events |
0.0 | 0.8 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.8 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
0.0 | 0.8 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 0.7 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 0.6 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
0.0 | 0.4 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 0.4 | PID_FOXO_PATHWAY | FoxO family signaling |
0.0 | 0.2 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 27 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 4.6 | REACTOME_HEMOSTASIS | Genes involved in Hemostasis |
0.2 | 3.3 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 3.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.1 | 2.9 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.1 | 1.8 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
0.1 | 1.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.1 | 1.4 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
0.1 | 1.4 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
0.1 | 1.3 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
0.0 | 1.1 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.0 | 1.1 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.0 | 1.1 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.0 | 1.0 | REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
0.0 | 0.9 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
0.1 | 0.8 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
0.1 | 0.8 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
0.0 | 0.8 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.1 | 0.6 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
0.0 | 0.6 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
0.0 | 0.6 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |