Motif ID: Foxc2

Z-value: 0.442


Transcription factors associated with Foxc2:

Gene SymbolEntrez IDGene Name
Foxc2 ENSMUSG00000046714.6 Foxc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc2mm10_v2_chr8_+_121116163_1211161770.104.5e-01Click!


Activity profile for motif Foxc2.

activity profile for motif Foxc2


Sorted Z-values histogram for motif Foxc2

Sorted Z-values for motif Foxc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 119 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_53850243 3.243 ENSMUST00000048485.5
 Sln
sarcolipin
chr8_-_84773381 3.194 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr4_+_48049080 2.446 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr4_-_87806296 1.908 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr2_-_62483637 1.381 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon

chr17_+_3532554 1.381 ENSMUST00000168560.1
 Cldn20
claudin 20
chr1_+_177444653 1.243 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr1_-_97977233 1.205 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr16_+_43363855 1.089 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr16_+_43364145 0.935 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr12_-_31950170 0.901 ENSMUST00000176520.1
 Hbp1
high mobility group box transcription factor 1
chr12_-_31950210 0.900 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
 Hbp1


high mobility group box transcription factor 1


chr13_+_40859768 0.790 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr6_+_8520008 0.781 ENSMUST00000162567.1
ENSMUST00000161217.1
 Glcci1

glucocorticoid induced transcript 1

chr16_-_74411292 0.772 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr6_+_17491216 0.767 ENSMUST00000080469.5
 Met
met proto-oncogene
chr2_-_77519565 0.759 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr5_-_111761697 0.751 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr16_-_22439719 0.688 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr1_+_179546303 0.686 ENSMUST00000040706.8
 Cnst
consortin, connexin sorting protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.2 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.2 3.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 2.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.8 2.4 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.3 2.4 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 2.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 1.4 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.1 1.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 1.2 GO:0009404 toxin metabolic process(GO:0009404)
0.0 1.2 GO:0021766 hippocampus development(GO:0021766)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 0.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.8 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.8 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2 0.7 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 0.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.7 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.7 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 0.6 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 0.6 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 2.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.2 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.6 GO:0032437 cuticular plate(GO:0032437)
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.1 GO:0012506 vesicle membrane(GO:0012506)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.4 GO:0005179 hormone activity(GO:0005179)
0.1 1.3 GO:0005521 lamin binding(GO:0005521)
0.4 1.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 1.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 1.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 0.8 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 0.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.7 GO:0071253 connexin binding(GO:0071253)
0.1 0.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.5 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.0 0.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.4 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 PID_MYC_PATHWAY C-MYC pathway
0.1 2.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 1.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.9 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.8 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor