Motif ID: Foxd1
Z-value: 1.714
Transcription factors associated with Foxd1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxd1 | ENSMUSG00000078302.3 | Foxd1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxd1 | mm10_v2_chr13_+_98354234_98354250 | -0.24 | 7.4e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 125 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 66.9 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 3.8 | 26.8 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 3.6 | 18.2 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.6 | 11.3 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.1 | 11.3 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 1.2 | 11.0 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 0.6 | 11.0 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.6 | 10.4 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.5 | 9.9 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 2.4 | 9.8 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.8 | 9.3 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.9 | 8.5 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.6 | 8.5 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 2.5 | 7.6 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.7 | 6.6 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.6 | 6.2 | GO:0071455 | cellular response to hyperoxia(GO:0071455) |
| 1.2 | 6.1 | GO:0050847 | progesterone receptor signaling pathway(GO:0050847) |
| 0.6 | 6.0 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 2.0 | 5.9 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
| 0.3 | 5.9 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 62 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 76.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 20.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 17.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.4 | 11.3 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 2.6 | 10.4 | GO:0044307 | dendritic branch(GO:0044307) |
| 0.0 | 9.7 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.2 | 9.6 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 9.3 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.6 | 8.5 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 7.7 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 6.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 6.1 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.2 | 6.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.7 | 5.9 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 5.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 5.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 5.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.3 | 5.1 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 5.1 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.4 | 5.0 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 99 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.6 | 66.9 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 8.9 | 26.8 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.0 | 15.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.5 | 12.0 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.8 | 9.8 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 1.6 | 9.4 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 2.3 | 9.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 8.7 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.3 | 8.5 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.3 | 7.1 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.1 | 7.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 7.0 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 6.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 6.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 6.2 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.6 | 6.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 6.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.9 | 6.0 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.6 | 5.9 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.0 | 5.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 35 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 76.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 19.8 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 18.0 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.6 | 17.8 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 9.8 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.5 | 9.3 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.4 | 9.0 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.2 | 8.6 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 6.6 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 6.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.2 | 6.4 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.1 | 5.9 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.1 | 5.4 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.1 | 5.1 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 4.1 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 3.1 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 3.0 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 2.8 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.1 | 2.8 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.1 | 2.8 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 36 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.4 | 10.4 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.2 | 9.3 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.4 | 8.6 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.3 | 8.6 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.2 | 7.6 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 7.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 7.0 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 6.0 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 5.9 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.8 | 5.8 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 5.7 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 4.0 | REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING | Genes involved in PI3K events in ERBB4 signaling |
| 0.3 | 3.7 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.3 | 3.2 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.3 | 3.1 | REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 0.1 | 3.1 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 3.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.5 | 3.0 | REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.0 | 3.0 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
