Motif ID: Foxd1
Z-value: 1.714
Transcription factors associated with Foxd1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxd1 | ENSMUSG00000078302.3 | Foxd1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxd1 | mm10_v2_chr13_+_98354234_98354250 | -0.24 | 7.4e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 66.9 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 3.8 | 26.8 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 3.6 | 18.2 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 2.5 | 7.6 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 2.4 | 9.8 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 2.0 | 5.9 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
| 1.9 | 5.7 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
| 1.7 | 5.1 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
| 1.7 | 5.0 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 1.6 | 4.8 | GO:0099547 | regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254) |
| 1.6 | 4.7 | GO:0014877 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 1.5 | 4.4 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 1.5 | 4.4 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 1.2 | 3.7 | GO:0043379 | rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 1.2 | 5.0 | GO:0002069 | columnar/cuboidal epithelial cell maturation(GO:0002069) |
| 1.2 | 11.0 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 1.2 | 6.1 | GO:0050847 | progesterone receptor signaling pathway(GO:0050847) |
| 1.2 | 4.8 | GO:0035461 | vitamin transmembrane transport(GO:0035461) |
| 1.1 | 4.5 | GO:0052151 | positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263) |
| 1.1 | 3.4 | GO:0090004 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 1.0 | 3.1 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 1.0 | 3.0 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.9 | 8.5 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.9 | 2.8 | GO:0015886 | heme transport(GO:0015886) |
| 0.8 | 9.3 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.8 | 4.1 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.8 | 2.4 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.8 | 4.0 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.7 | 6.6 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.7 | 4.9 | GO:0035826 | rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476) |
| 0.7 | 2.1 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.7 | 2.8 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.7 | 4.9 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.6 | 2.6 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.6 | 3.2 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.6 | 1.9 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.6 | 11.0 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.6 | 8.5 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.6 | 6.0 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.6 | 11.3 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.6 | 3.5 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
| 0.6 | 1.8 | GO:1902524 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 0.6 | 10.4 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.6 | 6.2 | GO:0071455 | cellular response to hyperoxia(GO:0071455) |
| 0.6 | 5.1 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.5 | 2.7 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.5 | 1.6 | GO:0045575 | basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575) |
| 0.5 | 9.9 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.4 | 2.7 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.4 | 1.7 | GO:0008355 | olfactory learning(GO:0008355) |
| 0.4 | 4.3 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.4 | 1.5 | GO:2000481 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of cAMP-dependent protein kinase activity(GO:2000481) |
| 0.4 | 3.5 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.4 | 1.5 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 0.4 | 5.6 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.4 | 1.9 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.4 | 2.8 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.3 | 3.2 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.3 | 5.9 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
| 0.3 | 1.5 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.3 | 4.2 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.2 | 1.2 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.2 | 1.2 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.2 | 1.7 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.2 | 2.8 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.2 | 1.6 | GO:2000258 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.2 | 2.3 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.2 | 0.7 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.2 | 1.3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.2 | 1.4 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.2 | 1.0 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.2 | 0.6 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.2 | 5.2 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.2 | 3.8 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.2 | 3.0 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.2 | 1.3 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.2 | 2.9 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.2 | 2.0 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.2 | 2.4 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.2 | 1.7 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.2 | 1.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.1 | 1.8 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.1 | 1.0 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.1 | 0.9 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.1 | 1.1 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 0.6 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.1 | 1.7 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.1 | 2.2 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 2.8 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 1.7 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 1.2 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.1 | 2.2 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.1 | 0.7 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.1 | 5.6 | GO:0048008 | platelet-derived growth factor receptor signaling pathway(GO:0048008) |
| 0.1 | 4.7 | GO:0046326 | positive regulation of glucose import(GO:0046326) |
| 0.1 | 2.5 | GO:0002931 | response to ischemia(GO:0002931) |
| 0.1 | 4.3 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.1 | 0.9 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.1 | 1.3 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.1 | 1.9 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 0.9 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.1 | 0.1 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.1 | 1.7 | GO:0019835 | cytolysis(GO:0019835) |
| 0.1 | 11.3 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.1 | 2.8 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
| 0.1 | 1.9 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.1 | 0.6 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 0.6 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
| 0.1 | 0.2 | GO:0034239 | regulation of macrophage fusion(GO:0034239) |
| 0.1 | 0.4 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 3.9 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 0.2 | GO:0032878 | regulation of establishment or maintenance of cell polarity(GO:0032878) |
| 0.0 | 3.1 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 0.4 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.0 | 0.2 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 0.0 | 1.2 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
| 0.0 | 2.1 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 1.1 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.0 | 0.3 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 0.4 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.0 | 2.2 | GO:0046488 | phosphatidylinositol metabolic process(GO:0046488) |
| 0.0 | 0.4 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 0.2 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.0 | 0.2 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 0.0 | 0.5 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 10.4 | GO:0044307 | dendritic branch(GO:0044307) |
| 1.2 | 3.7 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 1.2 | 4.8 | GO:1902737 | viral replication complex(GO:0019034) dendritic filopodium(GO:1902737) |
| 1.0 | 3.1 | GO:0098835 | presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) |
| 1.0 | 3.0 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.7 | 5.9 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.7 | 2.1 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.6 | 8.5 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.5 | 1.9 | GO:0031673 | H zone(GO:0031673) |
| 0.5 | 1.4 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.4 | 4.5 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.4 | 2.3 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.4 | 5.0 | GO:0030057 | desmosome(GO:0030057) |
| 0.4 | 11.3 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.3 | 3.8 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.3 | 4.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.3 | 5.1 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.2 | 9.6 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.2 | 2.4 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.2 | 6.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.2 | 1.5 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.2 | 1.7 | GO:0032300 | mismatch repair complex(GO:0032300) |
| 0.2 | 2.7 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.2 | 2.8 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.2 | 2.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 0.9 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 2.9 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.1 | 5.1 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 5.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 5.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 2.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 4.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 2.5 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 1.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 1.6 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.1 | 1.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 6.1 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 0.6 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.1 | 0.9 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.1 | 5.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 4.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 4.8 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 2.8 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 20.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 3.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 2.4 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 3.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 9.7 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 17.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.1 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.0 | 6.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 7.7 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 1.7 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 9.3 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.0 | 1.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.0 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 76.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 2.0 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 2.4 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 2.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 2.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 1.0 | GO:0005643 | nuclear pore(GO:0005643) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.6 | 66.9 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 8.9 | 26.8 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 2.3 | 9.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.7 | 5.0 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 1.6 | 9.4 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 1.2 | 4.9 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 1.0 | 2.9 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.9 | 2.8 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.9 | 6.0 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.8 | 4.2 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.8 | 9.8 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.7 | 4.9 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.7 | 2.8 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.7 | 2.1 | GO:0005118 | sevenless binding(GO:0005118) |
| 0.7 | 4.8 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.6 | 2.6 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.6 | 5.7 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.6 | 1.9 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.6 | 5.9 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.6 | 6.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.5 | 12.0 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.5 | 1.6 | GO:0035651 | AP-3 adaptor complex binding(GO:0035651) |
| 0.4 | 2.7 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.4 | 4.8 | GO:0090482 | vitamin transmembrane transporter activity(GO:0090482) |
| 0.4 | 1.7 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.4 | 3.4 | GO:0071253 | connexin binding(GO:0071253) |
| 0.3 | 3.1 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.3 | 2.7 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.3 | 1.0 | GO:0003963 | RNA-3'-phosphate cyclase activity(GO:0003963) |
| 0.3 | 8.5 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.3 | 4.2 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.3 | 2.9 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.3 | 7.1 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.3 | 1.7 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.3 | 2.5 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.3 | 2.1 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.3 | 2.8 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.2 | 4.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.2 | 1.2 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.2 | 0.8 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.2 | 2.2 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.2 | 0.6 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
| 0.2 | 6.2 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.2 | 2.3 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.2 | 1.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.2 | 3.7 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.2 | 1.0 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.1 | 4.5 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.1 | 4.7 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 0.9 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 3.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 2.4 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 5.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 4.4 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.1 | 1.9 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.1 | 2.8 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.1 | 0.4 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 6.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 7.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 4.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 1.0 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 7.0 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 3.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 6.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 4.4 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.1 | 1.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 3.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 5.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 2.8 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.1 | 2.8 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 1.5 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.2 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.0 | 2.2 | GO:0032934 | cholesterol binding(GO:0015485) sterol binding(GO:0032934) |
| 0.0 | 0.5 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.2 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.0 | 2.7 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 1.6 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 15.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 1.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.8 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 1.2 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 1.2 | GO:0000975 | regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212) |
| 0.0 | 1.0 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.6 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.4 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.3 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 8.7 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 5.1 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 1.1 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.0 | 1.8 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 5.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.7 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 6.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.1 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 0.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 5.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 0.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 76.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.6 | 17.8 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.5 | 9.3 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.4 | 9.0 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.3 | 6.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.3 | 18.0 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.2 | 6.6 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 6.4 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.2 | 8.6 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 2.8 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.1 | 5.4 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.1 | 5.9 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.1 | 2.2 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 19.8 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.3 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 1.6 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 4.1 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 9.8 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.1 | 5.1 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 3.0 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.2 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 3.1 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.8 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 1.4 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.8 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.1 | 2.8 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.3 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.4 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.7 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.7 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.6 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.1 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.1 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.7 | NABA_CORE_MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.0 | 0.2 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 5.8 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.5 | 3.0 | REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.4 | 10.4 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.4 | 8.6 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.3 | 2.8 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.3 | 3.2 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.3 | 3.7 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.3 | 6.0 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.3 | 3.1 | REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 0.3 | 8.6 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.2 | 9.3 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 11.9 | REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.2 | 2.6 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.2 | 5.9 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.2 | 2.1 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 7.6 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.2 | 5.7 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 3.1 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 1.9 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 7.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 4.0 | REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING | Genes involved in PI3K events in ERBB4 signaling |
| 0.1 | 1.6 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 1.4 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 7.0 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 1.9 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 0.9 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 3.0 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.6 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.5 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 2.8 | REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.0 | 3.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.7 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.2 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.3 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.7 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.7 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
