Motif ID: Foxd2

Z-value: 0.935


Transcription factors associated with Foxd2:

Gene SymbolEntrez IDGene Name
Foxd2 ENSMUSG00000055210.3 Foxd2



Activity profile for motif Foxd2.

activity profile for motif Foxd2


Sorted Z-values histogram for motif Foxd2

Sorted Z-values for motif Foxd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 101 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_104114088 11.914 ENSMUST00000031249.3
 Sparcl1
SPARC-like 1
chr18_+_37504264 11.231 ENSMUST00000052179.6
 Pcdhb20
protocadherin beta 20
chr14_+_101840602 10.974 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr14_+_101840501 10.257 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr4_-_136898803 7.734 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr14_-_30353468 7.137 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr15_+_92597104 6.689 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr14_+_80000292 6.429 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr18_+_51117754 6.310 ENSMUST00000116639.2
 Prr16
proline rich 16
chr3_+_89520152 6.295 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr15_+_3270767 6.236 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr18_+_37513652 6.232 ENSMUST00000061405.4
 Pcdhb21
protocadherin beta 21
chr13_+_16014457 5.845 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr10_+_67096456 5.476 ENSMUST00000174317.1
 Jmjd1c
jumonji domain containing 1C
chr16_+_43508118 5.082 ENSMUST00000114690.1
 Zbtb20
zinc finger and BTB domain containing 20
chr19_+_26748268 4.809 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
 Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2




chrX_-_105929206 4.792 ENSMUST00000134381.1
ENSMUST00000154866.1
 Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chrX_+_159697308 4.666 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr2_-_45110336 4.528 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr9_-_20879718 4.455 ENSMUST00000043726.6
 Angptl6
angiopoietin-like 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.5 GO:0007416 synapse assembly(GO:0007416)
3.0 11.8 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.2 8.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.8 7.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.3 6.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 6.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 6.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 6.3 GO:0045793 positive regulation of cell size(GO:0045793)
1.2 5.8 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.8 5.5 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.8 5.4 GO:0019532 oxalate transport(GO:0019532)
0.5 4.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.8 4.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 4.5 GO:0001525 angiogenesis(GO:0001525)
0.7 4.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 3.9 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 3.8 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.4 3.4 GO:0035095 behavioral response to nicotine(GO:0035095)
1.1 3.3 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.3 3.3 GO:0046541 saliva secretion(GO:0046541)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 19.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 11.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
3.0 11.8 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 11.1 GO:0060076 excitatory synapse(GO:0060076)
0.1 7.7 GO:0005581 collagen trimer(GO:0005581)
0.7 7.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 7.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.5 6.4 GO:0042581 specific granule(GO:0042581)
0.1 6.3 GO:0031594 neuromuscular junction(GO:0031594)
1.9 5.8 GO:0043512 inhibin A complex(GO:0043512)
0.3 4.8 GO:0071564 npBAF complex(GO:0071564)
0.1 4.8 GO:0045171 intercellular bridge(GO:0045171)
0.0 4.7 GO:0030139 endocytic vesicle(GO:0030139)
0.3 3.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 3.6 GO:0030141 secretory granule(GO:0030141)
0.3 3.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 3.3 GO:0043034 costamere(GO:0043034)
0.1 3.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 2.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 18.7 GO:0042805 actinin binding(GO:0042805)
0.2 11.9 GO:0050840 extracellular matrix binding(GO:0050840)
1.7 11.8 GO:0015616 DNA translocase activity(GO:0015616)
0.0 8.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9 7.1 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 7.0 GO:0045296 cadherin binding(GO:0045296)
1.6 6.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
1.0 5.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 5.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.5 5.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 4.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 4.8 GO:0008017 microtubule binding(GO:0008017)
0.0 4.7 GO:0017124 SH3 domain binding(GO:0017124)
0.1 4.5 GO:0070412 R-SMAD binding(GO:0070412)
1.0 4.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 4.0 GO:0005096 GTPase activator activity(GO:0005096)
0.3 3.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.3 3.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 3.2 GO:0005521 lamin binding(GO:0005521)
0.5 2.6 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 6.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 5.8 PID_ALK1_PATHWAY ALK1 signaling events
0.1 4.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 4.0 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 3.2 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 2.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.3 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.2 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 6.3 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
1.5 5.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 5.6 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 5.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 5.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 4.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4 3.4 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 2.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 2.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 1.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.2 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 0.7 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.3 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin