Motif ID: Foxd3

Z-value: 0.578


Transcription factors associated with Foxd3:

Gene SymbolEntrez IDGene Name
Foxd3 ENSMUSG00000067261.3 Foxd3



Activity profile for motif Foxd3.

activity profile for motif Foxd3


Sorted Z-values histogram for motif Foxd3

Sorted Z-values for motif Foxd3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_93199348 3.181 ENSMUST00000064775.6
Adcyap1
adenylate cyclase activating polypeptide 1
chr17_+_29090969 2.844 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr14_-_70630149 2.747 ENSMUST00000022694.9
Dmtn
dematin actin binding protein
chr5_+_148265202 2.536 ENSMUST00000110515.2
Mtus2
microtubule associated tumor suppressor candidate 2
chr6_-_144209471 2.133 ENSMUST00000038815.7
Sox5
SRY-box containing gene 5
chr5_+_148265307 2.102 ENSMUST00000110514.1
Mtus2
microtubule associated tumor suppressor candidate 2
chr5_+_148265265 2.095 ENSMUST00000071878.5
Mtus2
microtubule associated tumor suppressor candidate 2
chr6_-_144209558 2.069 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr4_-_36056726 1.988 ENSMUST00000108124.3
Lingo2
leucine rich repeat and Ig domain containing 2
chr3_+_102010138 1.888 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr1_+_6734827 1.823 ENSMUST00000139838.1
St18
suppression of tumorigenicity 18
chr10_-_11080956 1.741 ENSMUST00000105560.1
Grm1
glutamate receptor, metabotropic 1
chr1_-_126830632 1.716 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr16_+_13986596 1.659 ENSMUST00000056521.5
ENSMUST00000118412.1
ENSMUST00000131608.1
2900011O08Rik


RIKEN cDNA 2900011O08 gene


chr14_-_93888732 1.540 ENSMUST00000068992.2
Pcdh9
protocadherin 9
chr6_+_77242644 1.520 ENSMUST00000159616.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr6_+_77242715 1.516 ENSMUST00000161677.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr1_-_126830786 1.515 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr11_+_98798653 1.165 ENSMUST00000037930.6
Msl1
male-specific lethal 1 homolog (Drosophila)
chr8_-_87959560 1.060 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr6_-_3494587 1.056 ENSMUST00000049985.8
Hepacam2
HEPACAM family member 2
chr11_+_83302817 1.006 ENSMUST00000142680.1
Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr9_+_54980880 0.998 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chrX_+_164373363 0.961 ENSMUST00000033751.7
Figf
c-fos induced growth factor
chr17_+_28691419 0.911 ENSMUST00000124886.1
Mapk14
mitogen-activated protein kinase 14
chr5_-_88675190 0.870 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr15_+_100154379 0.845 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chrX_-_163761323 0.762 ENSMUST00000059320.2
Rnf138rt1
ring finger protein 138, retrogene 1
chr2_-_120539852 0.750 ENSMUST00000171215.1
Zfp106
zinc finger protein 106
chr2_+_152669461 0.735 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
H13



histocompatibility 13



chr12_+_111971545 0.703 ENSMUST00000079009.5
Tdrd9
tudor domain containing 9
chr15_+_92597104 0.653 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr14_-_52213379 0.591 ENSMUST00000140603.1
Chd8
chromodomain helicase DNA binding protein 8
chr2_+_9882622 0.568 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr11_-_107189325 0.527 ENSMUST00000018577.7
ENSMUST00000106757.1
Nol11

nucleolar protein 11

chr2_+_125136692 0.521 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr10_-_19011948 0.443 ENSMUST00000105527.1
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr6_-_137571007 0.440 ENSMUST00000100841.2
Eps8
epidermal growth factor receptor pathway substrate 8
chr18_+_37513652 0.414 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr9_+_105642957 0.393 ENSMUST00000065778.6
Pik3r4
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
chr13_+_16014457 0.382 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr6_+_38918969 0.330 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chr2_-_45110336 0.290 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr3_+_76075583 0.285 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr18_+_37725706 0.280 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr2_+_14388434 0.280 ENSMUST00000133258.1
Slc39a12
solute carrier family 39 (zinc transporter), member 12
chr2_+_181767040 0.279 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr1_+_134415414 0.278 ENSMUST00000112237.1
Adipor1
adiponectin receptor 1
chr13_-_18031616 0.276 ENSMUST00000099736.2
Vdac3-ps1
voltage-dependent anion channel 3, pseudogene 1
chr9_-_20879718 0.271 ENSMUST00000043726.6
Angptl6
angiopoietin-like 6
chr5_-_120612558 0.263 ENSMUST00000140554.1
ENSMUST00000031599.2
ENSMUST00000177800.1
1110008J03Rik


RIKEN cDNA 1110008J03 gene


chr12_+_38783455 0.234 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chr17_+_28691342 0.214 ENSMUST00000114758.1
ENSMUST00000004990.6
ENSMUST00000062694.8
ENSMUST00000114754.1
Mapk14



mitogen-activated protein kinase 14



chr4_-_136898803 0.200 ENSMUST00000046285.5
C1qa
complement component 1, q subcomponent, alpha polypeptide
chr2_+_181767283 0.193 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chr9_+_36832684 0.181 ENSMUST00000034630.8
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr4_-_82850721 0.181 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr10_-_127030813 0.134 ENSMUST00000040560.4
Tsfm
Ts translation elongation factor, mitochondrial
chr16_-_4880284 0.124 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr10_-_127030789 0.085 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm

Ts translation elongation factor, mitochondrial

chr10_+_11609256 0.073 ENSMUST00000052902.7
Gm9797
predicted pseudogene 9797
chr1_-_170867761 0.068 ENSMUST00000027974.6
Atf6
activating transcription factor 6
chr19_+_8953826 0.048 ENSMUST00000096239.5
Tut1
terminal uridylyl transferase 1, U6 snRNA-specific
chr12_+_38783503 0.047 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr5_-_31295862 0.028 ENSMUST00000041266.7
ENSMUST00000172435.1
Fndc4

fibronectin type III domain containing 4

chr19_-_8713862 0.011 ENSMUST00000010239.4
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr4_+_115737754 0.001 ENSMUST00000106522.2
Efcab14
EF-hand calcium binding domain 14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0071649 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.9 2.7 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.6 1.7 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.5 4.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.4 1.7 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.3 2.8 GO:0071493 cellular response to UV-B(GO:0071493)
0.3 1.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.2 0.7 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.2 1.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 0.4 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.1 0.7 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 3.0 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 1.0 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 1.0 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.4 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 0.5 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.1 1.9 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.2 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.6 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 1.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.5 GO:0060539 diaphragm development(GO:0060539)
0.0 0.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.3 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.0 2.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.2 GO:0048733 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) sebaceous gland development(GO:0048733)
0.0 0.2 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0070557 PCNA-p21 complex(GO:0070557)
0.7 2.7 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.2 1.2 GO:0072487 MSL complex(GO:0072487)
0.1 0.7 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 1.7 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.1 0.4 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.4 GO:0043512 inhibin A complex(GO:0043512)
0.1 6.7 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.7 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 3.2 GO:0043195 terminal bouton(GO:0043195)
0.0 0.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 4.6 GO:0030426 growth cone(GO:0030426)
0.0 3.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.8 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.4 1.7 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.2 3.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 1.1 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.8 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.3 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 2.7 GO:0030507 spectrin binding(GO:0030507)
0.0 1.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 3.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 6.7 GO:0008017 microtubule binding(GO:0008017)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.0 GO:0030276 clathrin binding(GO:0030276)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.1 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.4 PID_ALK1_PATHWAY ALK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.0 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 2.8 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 0.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.1 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 3.2 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 1.0 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.4 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway