Motif ID: Foxf2

Z-value: 1.084


Transcription factors associated with Foxf2:

Gene SymbolEntrez IDGene Name
Foxf2 ENSMUSG00000038402.2 Foxf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxf2mm10_v2_chr13_+_31625802_316258160.152.8e-01Click!


Activity profile for motif Foxf2.

activity profile for motif Foxf2


Sorted Z-values histogram for motif Foxf2

Sorted Z-values for motif Foxf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 114 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66969616 22.212 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr6_-_148444336 18.553 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr10_+_60106452 9.873 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr15_+_3270767 9.730 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr7_+_82175156 9.350 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr8_-_84773381 8.480 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr16_-_22439570 7.056 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr7_-_4844665 6.511 ENSMUST00000066041.5
ENSMUST00000172377.1
 Shisa7

shisa homolog 7 (Xenopus laevis)

chr4_+_101507947 6.446 ENSMUST00000149047.1
ENSMUST00000106929.3
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr1_-_87573825 6.397 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor
chr4_+_101507855 6.062 ENSMUST00000038207.5
 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr16_-_22439719 6.046 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_+_91269759 5.958 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr3_-_144202300 5.436 ENSMUST00000121796.1
ENSMUST00000121112.1
 Lmo4

LIM domain only 4

chr16_-_4880284 4.551 ENSMUST00000037843.6
 Ubald1
UBA-like domain containing 1
chr10_+_79716588 4.441 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr12_-_112511136 4.385 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr7_+_45783686 4.330 ENSMUST00000118564.1
ENSMUST00000133428.1
 Lmtk3

lemur tyrosine kinase 3

chr17_+_70522083 4.224 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr4_+_5724304 4.095 ENSMUST00000108380.1
 Fam110b
family with sequence similarity 110, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 22.2 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 18.6 GO:0006396 RNA processing(GO:0006396)
2.7 13.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
2.1 12.5 GO:0072318 clathrin coat disassembly(GO:0072318)
1.1 9.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.0 9.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.5 8.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 8.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 7.9 GO:0070842 aggresome assembly(GO:0070842)
0.8 6.6 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.6 6.4 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 6.0 GO:0048663 neuron fate commitment(GO:0048663)
0.4 5.4 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.9 4.4 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.1 3.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 3.7 GO:0050919 negative chemotaxis(GO:0050919)
0.2 3.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 3.5 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.6 3.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.4 3.2 GO:0033625 positive regulation of integrin activation(GO:0033625)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 28.0 GO:0005739 mitochondrion(GO:0005739)
0.1 27.6 GO:0014069 postsynaptic density(GO:0014069)
0.7 25.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 10.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 9.4 GO:0005769 early endosome(GO:0005769)
0.1 6.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 5.4 GO:0031252 cell leading edge(GO:0031252)
1.5 4.4 GO:0098855 HCN channel complex(GO:0098855)
0.1 3.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 3.2 GO:1990635 proximal dendrite(GO:1990635)
1.0 2.9 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.3 2.9 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.2 2.9 GO:0070852 cell body fiber(GO:0070852)
0.6 2.4 GO:0031673 H zone(GO:0031673)
0.0 2.4 GO:0016324 apical plasma membrane(GO:0016324)
0.2 2.3 GO:0071437 invadopodium(GO:0071437)
0.0 2.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.2 GO:0005811 lipid particle(GO:0005811)
0.0 2.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.5 GO:0031931 TORC1 complex(GO:0031931)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 22.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 16.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 12.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 9.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 8.7 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 8.6 GO:0019904 protein domain specific binding(GO:0019904)
0.2 6.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 6.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 6.4 GO:0008289 lipid binding(GO:0008289)
1.1 4.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.7 3.9 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 3.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.8 3.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 3.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 2.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 2.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.5 2.8 GO:0097001 ceramide binding(GO:0097001)
0.1 2.7 GO:0070888 E-box binding(GO:0070888)
0.0 2.5 GO:0019213 deacetylase activity(GO:0019213)
0.0 2.5 GO:0035326 enhancer binding(GO:0035326)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 22.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.4 13.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 9.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 6.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 6.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 5.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 5.4 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 4.4 PID_LKB1_PATHWAY LKB1 signaling events
0.2 3.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 3.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 2.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.4 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 1.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 1.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.2 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 13.3 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 13.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 5.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 4.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 4.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 3.9 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.2 3.4 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.2 REACTOME_SIGNALLING_BY_NGF Genes involved in Signalling by NGF
0.0 3.2 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 2.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.3 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.1 2.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 2.1 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 1.0 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation