Motif ID: Foxi1_Foxo1

Z-value: 2.529

Transcription factors associated with Foxi1_Foxo1:

Gene SymbolEntrez IDGene Name
Foxi1 ENSMUSG00000047861.2 Foxi1
Foxo1 ENSMUSG00000044167.5 Foxo1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo1mm10_v2_chr3_+_52268337_52268388-0.085.5e-01Click!


Activity profile for motif Foxi1_Foxo1.

activity profile for motif Foxi1_Foxo1


Sorted Z-values histogram for motif Foxi1_Foxo1

Sorted Z-values for motif Foxi1_Foxo1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxi1_Foxo1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 65.722 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr17_-_70851710 44.153 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr3_-_52104891 36.922 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr2_+_181767283 30.010 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr2_+_181767040 30.002 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr15_+_25752860 29.938 ENSMUST00000022882.5
ENSMUST00000135173.1
 Myo10

myosin X

chr3_+_34649987 29.332 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2
chr3_-_27153861 28.413 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr3_-_27153844 27.588 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr14_+_73237891 26.754 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr7_-_115824699 25.725 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr10_-_92165159 25.383 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr4_-_97584605 23.777 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 23.579 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr3_-_27153782 23.235 ENSMUST00000175857.1
ENSMUST00000177055.1
ENSMUST00000176535.1
 Ect2


ect2 oncogene


chr7_-_37773555 23.214 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr2_-_69206146 22.217 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr6_+_53573364 21.515 ENSMUST00000047450.7
 Creb5
cAMP responsive element binding protein 5
chr1_+_6487231 21.263 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr11_-_101551837 20.451 ENSMUST00000017290.4
 Brca1
breast cancer 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 477 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.1 91.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
11.0 65.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
3.9 62.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
5.5 60.0 GO:0060539 diaphragm development(GO:0060539)
7.1 49.7 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838)
1.8 48.4 GO:0006270 DNA replication initiation(GO:0006270)
3.8 42.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
2.9 37.7 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
3.1 37.0 GO:0060013 righting reflex(GO:0060013)
1.6 36.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
3.2 35.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.9 35.5 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
1.1 34.0 GO:0042462 eye photoreceptor cell development(GO:0042462)
1.9 33.1 GO:0040034 regulation of development, heterochronic(GO:0040034)
6.4 31.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
5.1 30.5 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
3.7 29.5 GO:0048625 myoblast fate commitment(GO:0048625)
5.5 27.5 GO:0015671 oxygen transport(GO:0015671)
1.8 27.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.7 27.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 211.8 GO:0005634 nucleus(GO:0005634)
0.1 114.7 GO:0005654 nucleoplasm(GO:0005654)
17.5 87.7 GO:0097149 centralspindlin complex(GO:0097149)
0.2 68.7 GO:0016607 nuclear speck(GO:0016607)
1.1 66.1 GO:0005871 kinesin complex(GO:0005871)
1.0 53.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 50.4 GO:0005667 transcription factor complex(GO:0005667)
0.3 47.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
6.6 39.5 GO:0031262 Ndc80 complex(GO:0031262)
0.3 38.6 GO:0000776 kinetochore(GO:0000776)
0.6 38.0 GO:0016459 myosin complex(GO:0016459)
4.1 37.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 36.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
4.0 36.2 GO:0030478 actin cap(GO:0030478)
0.4 33.1 GO:0005902 microvillus(GO:0005902)
3.5 31.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
9.6 28.8 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 28.2 GO:0032993 protein-DNA complex(GO:0032993)
0.4 24.0 GO:0005844 polysome(GO:0005844)
1.8 22.8 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 311 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 172.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 125.4 GO:0003677 DNA binding(GO:0003677)
0.7 90.7 GO:0017048 Rho GTPase binding(GO:0017048)
2.6 70.5 GO:0008432 JUN kinase binding(GO:0008432)
1.2 47.3 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.5 46.5 GO:0003774 motor activity(GO:0003774)
2.8 42.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.1 37.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.3 36.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
5.2 36.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
3.2 35.7 GO:0015250 water channel activity(GO:0015250)
2.0 35.7 GO:0045295 gamma-catenin binding(GO:0045295)
1.9 31.9 GO:0051010 microtubule plus-end binding(GO:0051010)
9.6 28.8 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
5.5 27.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.5 26.7 GO:0003684 damaged DNA binding(GO:0003684)
0.7 25.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 24.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
1.3 24.2 GO:0035198 miRNA binding(GO:0035198)
0.3 22.8 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 141.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
1.6 86.6 PID_PLK1_PATHWAY PLK1 signaling events
1.6 78.4 PID_AURORA_B_PATHWAY Aurora B signaling
1.3 60.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
3.2 45.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.8 42.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.6 36.8 PID_AP1_PATHWAY AP-1 transcription factor network
3.9 30.9 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.7 28.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.7 27.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.8 26.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.6 25.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.7 23.1 PID_ATR_PATHWAY ATR signaling pathway
0.5 19.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.7 19.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 17.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 16.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.7 15.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.8 13.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.3 13.0 PID_ILK_PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 138.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.9 89.0 REACTOME_G1_PHASE Genes involved in G1 Phase
1.0 77.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
2.0 54.2 REACTOME_KINESINS Genes involved in Kinesins
1.4 45.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
2.6 44.1 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
2.3 43.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
1.0 37.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
3.7 33.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
2.0 31.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.7 30.6 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.5 22.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.5 20.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 20.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 20.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
1.8 19.6 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.3 19.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
1.7 19.2 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.5 18.2 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
1.0 15.7 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL