Motif ID: Foxj3_Tbl1xr1

Z-value: 1.094

Transcription factors associated with Foxj3_Tbl1xr1:

Gene SymbolEntrez IDGene Name
Foxj3 ENSMUSG00000032998.10 Foxj3
Tbl1xr1 ENSMUSG00000027630.8 Tbl1xr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxj3mm10_v2_chr4_+_119539652_119539698-0.265.1e-02Click!
Tbl1xr1mm10_v2_chr3_+_22076644_22076681-0.239.0e-02Click!


Activity profile for motif Foxj3_Tbl1xr1.

activity profile for motif Foxj3_Tbl1xr1


Sorted Z-values histogram for motif Foxj3_Tbl1xr1

Sorted Z-values for motif Foxj3_Tbl1xr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxj3_Tbl1xr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_98169542 4.350 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr8_-_53638945 4.245 ENSMUST00000047768.4
 Neil3
nei like 3 (E. coli)
chr6_+_138140298 4.008 ENSMUST00000008684.4
 Mgst1
microsomal glutathione S-transferase 1
chr7_+_67647405 3.705 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr6_+_134929089 3.694 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr14_-_65833963 3.603 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr4_+_11704439 3.598 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr18_-_74207771 3.541 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr19_+_55741810 3.417 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr5_-_135251209 3.390 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr3_+_135212557 3.385 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr11_+_69045640 3.367 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chr13_+_51846673 3.306 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr3_+_159495408 3.288 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr17_+_43667389 3.201 ENSMUST00000170988.1
 Cyp39a1
cytochrome P450, family 39, subfamily a, polypeptide 1
chr1_+_136467958 3.152 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr2_+_118813995 3.128 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr17_-_35704000 3.048 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr10_-_92165159 3.022 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr4_+_128846163 2.995 ENSMUST00000138291.1
 Gm12968
predicted gene 12968

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,030 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.7 11.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 11.9 GO:0007059 chromosome segregation(GO:0007059)
0.2 9.4 GO:0051310 metaphase plate congression(GO:0051310)
1.1 8.7 GO:0048625 myoblast fate commitment(GO:0048625)
0.7 8.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.4 7.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.2 7.1 GO:0006270 DNA replication initiation(GO:0006270)
1.7 6.9 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.6 6.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.1 6.4 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
1.0 6.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.6 6.0 GO:0048664 neuron fate determination(GO:0048664)
0.5 5.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 5.7 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 5.5 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.3 5.4 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.1 5.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.2 5.2 GO:0006284 base-excision repair(GO:0006284)
0.1 5.2 GO:0002181 cytoplasmic translation(GO:0002181)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 328 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.8 GO:0005667 transcription factor complex(GO:0005667)
0.1 14.4 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 14.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.9 11.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 10.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 10.7 GO:0016459 myosin complex(GO:0016459)
0.1 9.5 GO:0005759 mitochondrial matrix(GO:0005759)
1.0 9.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.5 9.1 GO:0031262 Ndc80 complex(GO:0031262)
0.3 9.0 GO:0051233 spindle midzone(GO:0051233)
0.1 8.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 7.7 GO:0005814 centriole(GO:0005814)
0.1 6.5 GO:0005657 replication fork(GO:0005657)
0.3 6.4 GO:0031527 filopodium membrane(GO:0031527)
0.1 6.3 GO:0015934 large ribosomal subunit(GO:0015934)
0.4 6.1 GO:0042788 polysomal ribosome(GO:0042788)
0.2 6.1 GO:0035371 microtubule plus-end(GO:0035371)
0.1 5.8 GO:0032993 protein-DNA complex(GO:0032993)
0.3 5.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 5.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 555 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 20.4 GO:0003677 DNA binding(GO:0003677)
0.1 12.9 GO:0003774 motor activity(GO:0003774)
0.1 11.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 10.4 GO:0042393 histone binding(GO:0042393)
0.0 10.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.4 9.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.5 9.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
1.2 8.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 8.3 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.2 8.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 7.6 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.3 6.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
1.0 6.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 6.8 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.6 6.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.7 6.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 6.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.9 5.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 5.5 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 25.1 PID_PLK1_PATHWAY PLK1 signaling events
0.4 15.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 11.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 9.7 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 9.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 9.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 7.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 7.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 7.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 7.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 7.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 4.9 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 4.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 4.2 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 4.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 4.0 PID_BARD1_PATHWAY BARD1 signaling events
0.1 3.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 47.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 13.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 12.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.3 9.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.4 8.9 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.2 8.4 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.4 7.4 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 6.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 5.2 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.5 5.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 5.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 4.7 REACTOME_KINESINS Genes involved in Kinesins
0.2 4.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 4.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 4.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 4.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 4.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 4.4 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.2 4.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 4.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression