Motif ID: Foxk1_Foxj1

Z-value: 0.638

Transcription factors associated with Foxk1_Foxj1:

Gene SymbolEntrez IDGene Name
Foxj1 ENSMUSG00000034227.7 Foxj1
Foxk1 ENSMUSG00000056493.8 Foxk1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxj1mm10_v2_chr11_-_116335384_1163353990.491.7e-04Click!
Foxk1mm10_v2_chr5_+_142401484_142401532-0.431.1e-03Click!


Activity profile for motif Foxk1_Foxj1.

activity profile for motif Foxk1_Foxj1


Sorted Z-values histogram for motif Foxk1_Foxj1

Sorted Z-values for motif Foxk1_Foxj1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxk1_Foxj1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_117178726 6.202 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr10_-_92165159 5.098 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr11_+_119022962 3.765 ENSMUST00000026662.7
 Cbx2
chromobox 2
chr10_-_130280218 3.686 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr3_+_159495408 3.596 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr3_-_100969644 3.540 ENSMUST00000076941.5
 Ttf2
transcription termination factor, RNA polymerase II
chr5_+_30666886 3.436 ENSMUST00000144742.1
 Cenpa
centromere protein A
chr13_-_103920295 3.399 ENSMUST00000169083.1
 Erbb2ip
Erbb2 interacting protein
chr9_-_100506844 3.387 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr10_-_92164666 3.053 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr18_-_62756275 2.999 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr1_-_97977233 2.945 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr4_-_43499608 2.826 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr14_-_62456286 2.761 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr14_+_46832127 2.535 ENSMUST00000068532.8
 Cgrrf1
cell growth regulator with ring finger domain 1
chr5_+_92809372 2.207 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr1_+_136467958 2.199 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr19_+_37376359 2.171 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr1_-_144177259 2.162 ENSMUST00000111941.1
ENSMUST00000052375.1
 Rgs13

regulator of G-protein signaling 13

chr3_+_131110350 2.150 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 6.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.3 4.8 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.1 4.2 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.3 3.7 GO:0035881 amacrine cell differentiation(GO:0035881)
0.2 3.5 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.1 3.5 GO:0042462 eye photoreceptor cell development(GO:0042462)
1.1 3.4 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.6 3.1 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
0.3 3.1 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.3 3.0 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 2.9 GO:0009404 toxin metabolic process(GO:0009404)
0.1 2.4 GO:0006284 base-excision repair(GO:0006284)
0.1 2.3 GO:0030033 microvillus assembly(GO:0030033)
0.0 2.3 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099)
0.5 2.2 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.2 2.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.7 2.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.0 2.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 1.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.8 GO:0006270 DNA replication initiation(GO:0006270)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 GO:0005667 transcription factor complex(GO:0005667)
0.2 5.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 5.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 4.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.0 4.1 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.2 3.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 3.8 GO:0005681 spliceosomal complex(GO:0005681)
0.0 3.7 GO:0005902 microvillus(GO:0005902)
0.3 3.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 3.4 GO:0051233 spindle midzone(GO:0051233)
0.1 3.0 GO:0097546 ciliary base(GO:0097546)
0.2 2.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 2.5 GO:0030667 secretory granule membrane(GO:0030667)
0.2 2.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.6 1.9 GO:0042585 germinal vesicle(GO:0042585)
0.5 1.6 GO:0071914 prominosome(GO:0071914)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.5 GO:0070469 respiratory chain(GO:0070469)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.4 GO:0000800 lateral element(GO:0000800)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0051015 actin filament binding(GO:0051015)
0.3 5.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 5.1 GO:0004386 helicase activity(GO:0004386)
0.1 4.5 GO:0035064 methylated histone binding(GO:0035064)
0.2 4.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 4.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.6 3.7 GO:0030284 estrogen receptor activity(GO:0030284)
0.6 3.4 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 3.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 3.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 3.1 GO:0042936 dipeptide transporter activity(GO:0042936)
1.0 2.9 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 2.0 GO:0005521 lamin binding(GO:0005521)
0.1 2.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 1.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.4 1.8 GO:0000405 bubble DNA binding(GO:0000405)
0.1 1.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 1.7 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.6 GO:0042805 actinin binding(GO:0042805)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 2.9 PID_MYC_PATHWAY C-MYC pathway
0.0 2.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.5 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.4 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.4 REACTOME_KINESINS Genes involved in Kinesins
0.1 5.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 3.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 3.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 1.9 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.7 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 1.4 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.1 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 0.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 0.7 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 0.7 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.7 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation