Motif ID: Foxo4
Z-value: 0.702
Transcription factors associated with Foxo4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxo4 | ENSMUSG00000042903.7 | Foxo4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxo4 | mm10_v2_chrX_+_101254528_101254574 | 0.53 | 3.7e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.0 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 1.0 | 4.9 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.6 | 1.7 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.5 | 5.2 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.3 | 0.8 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.2 | 0.6 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 0.2 | 1.9 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.2 | 0.5 | GO:0045349 | regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.2 | 1.9 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.1 | 2.1 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 1.9 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 1.9 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 0.5 | GO:1904451 | regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453) |
| 0.1 | 0.7 | GO:0070458 | detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458) |
| 0.1 | 1.3 | GO:0045671 | negative regulation of osteoclast differentiation(GO:0045671) |
| 0.1 | 0.3 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.1 | 0.2 | GO:0032829 | positive regulation of T cell anergy(GO:0002669) negative regulation of T cell cytokine production(GO:0002725) positive regulation of lymphocyte anergy(GO:0002913) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of immature T cell proliferation in thymus(GO:0033092) negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.0 | 0.4 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 0.0 | 0.6 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.0 | 0.3 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
| 0.0 | 0.4 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.0 | 0.2 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.0 | 0.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.2 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
| 0.0 | 0.9 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.2 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.0 | 0.0 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.0 | 1.3 | GO:0046888 | negative regulation of hormone secretion(GO:0046888) |
| 0.0 | 0.1 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.0 | 0.8 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.0 | 1.4 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.8 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.2 | 2.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.5 | GO:0097574 | lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795) |
| 0.1 | 0.5 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 0.3 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 0.7 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 0.2 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.0 | 0.3 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.0 | 2.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 0.6 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.4 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 0.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 1.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 5.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 1.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.7 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.2 | 0.8 | GO:0031721 | haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721) |
| 0.1 | 1.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.4 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.1 | 0.3 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.1 | 3.0 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 0.4 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.1 | 0.8 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 0.5 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.4 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.0 | 0.2 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 0.2 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.0 | 5.2 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.7 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.6 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.2 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.0 | 0.7 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.0 | 0.1 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 0.6 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 0.3 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 2.5 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.8 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.1 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.5 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.5 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 2.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.6 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.5 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.0 | 0.8 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 0.6 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 0.5 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 2.1 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.7 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.5 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.2 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.3 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.4 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
