Motif ID: Foxo4

Z-value: 0.702


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.533.7e-05Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Showing 1 to 20 of 93 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_5796924 4.877 ENSMUST00000174808.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr4_-_97778042 3.249 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_+_8690399 3.031 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr2_+_181767283 2.688 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chr2_+_181767040 2.492 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr17_+_78508063 2.466 ENSMUST00000024880.9
Vit
vitrin
chr2_-_175931051 2.372 ENSMUST00000108949.2
ENSMUST00000109018.2
Gm8898

predicted gene 8898

chr2_-_175338197 2.285 ENSMUST00000121393.2
Gm4631
predicted gene 4631
chr17_-_51831884 2.101 ENSMUST00000124222.1
Satb1
special AT-rich sequence binding protein 1
chr2_+_176521056 1.985 ENSMUST00000108997.2
ENSMUST00000178443.1
Gm14431

predicted gene 14431

chr4_-_32950813 1.924 ENSMUST00000084750.1
ENSMUST00000084748.2
Ankrd6

ankyrin repeat domain 6

chr4_+_97777606 1.914 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr1_+_6487231 1.907 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr2_-_175141999 1.852 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
Gm14399


predicted gene 14399


chr2_+_175469985 1.787 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr2_-_175703646 1.733 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245


predicted gene 4245


chr2_+_175372436 1.716 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723


predicted gene 4723


chr14_-_98169542 1.712 ENSMUST00000069334.7
ENSMUST00000071533.6
Dach1

dachshund 1 (Drosophila)

chr11_-_102579461 1.553 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr2_-_177957239 1.524 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
Gm14326


predicted gene 14326



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.2 GO:0060539 diaphragm development(GO:0060539)
1.0 4.9 GO:0035063 nuclear speck organization(GO:0035063)
1.0 3.0 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 2.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 1.9 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 1.9 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 1.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.9 GO:0072189 ureter development(GO:0072189)
0.6 1.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 1.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.3 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 1.3 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.0 0.9 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.3 0.8 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.0 0.8 GO:0030279 negative regulation of ossification(GO:0030279)
0.1 0.7 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.2 0.6 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.6 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.6 GO:0015701 bicarbonate transport(GO:0015701)
0.2 0.5 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0016607 nuclear speck(GO:0016607)
0.2 2.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.1 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.5 GO:0072562 blood microparticle(GO:0072562)
0.2 0.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.5 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.2 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 3.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.5 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.1 1.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 1.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 0.8 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 0.8 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.7 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.7 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.4 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.4 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.3 GO:0030172 troponin C binding(GO:0030172)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 2.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.5 PID_TNF_PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.8 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 0.5 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport