Motif ID: Foxo6

Z-value: 0.385


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_120287349-0.095.3e-01Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

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Top targets:


Showing 1 to 20 of 74 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12027958 3.504 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr5_+_110330697 2.264 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr4_+_134510999 2.176 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr1_+_74391479 1.885 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr10_-_93310963 1.842 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr10_-_93311073 1.790 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr14_-_47418407 1.726 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chrX_+_106920618 1.659 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr6_-_23248264 1.444 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_+_51987139 1.279 ENSMUST00000168302.1
 Stat4
signal transducer and activator of transcription 4
chr19_-_45742873 1.146 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr12_-_91384403 1.123 ENSMUST00000141429.1
 Cep128
centrosomal protein 128
chr5_-_99037035 1.102 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr5_+_7179299 1.062 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr17_-_24696147 1.057 ENSMUST00000046839.8
 Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr5_-_117389029 1.012 ENSMUST00000111953.1
ENSMUST00000086461.6
 Rfc5

replication factor C (activator 1) 5

chr17_-_31277327 0.940 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chrX_-_163761323 0.921 ENSMUST00000059320.2
 Rnf138rt1
ring finger protein 138, retrogene 1
chr7_+_28808795 0.903 ENSMUST00000172529.1
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chrX_+_134585644 0.818 ENSMUST00000113211.1
 Rpl36a
ribosomal protein L36A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0042060 wound healing(GO:0042060)
0.4 3.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.8 2.3 GO:0045004 DNA replication proofreading(GO:0045004)
0.0 2.1 GO:0007051 spindle organization(GO:0007051)
0.0 1.9 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 1.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2 1.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 1.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.4 1.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.2 1.1 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.1 1.1 GO:0097421 liver regeneration(GO:0097421)
0.1 1.0 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.9 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.9 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.7 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.7 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1 0.6 GO:0050957 equilibrioception(GO:0050957)
0.1 0.5 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.5 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0000922 spindle pole(GO:0000922)
0.5 2.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 2.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 1.0 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.9 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.5 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 3.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 2.3 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.2 1.9 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 1.7 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 1.2 GO:0019843 rRNA binding(GO:0019843)
0.4 1.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 1.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.3 1.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 1.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.9 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 0.7 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 0.5 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 0.5 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.0 0.2 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.2 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 PID_IGF1_PATHWAY IGF1 pathway
0.1 1.9 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 1.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 1.3 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.1 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.0 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 3.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 2.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 1.7 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.1 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds