Motif ID: Foxp1_Foxj2

Z-value: 1.242

Transcription factors associated with Foxp1_Foxj2:

Gene SymbolEntrez IDGene Name
Foxj2 ENSMUSG00000003154.9 Foxj2
Foxp1 ENSMUSG00000030067.11 Foxp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxj2mm10_v2_chr6_+_122819888_1228199380.795.1e-13Click!
Foxp1mm10_v2_chr6_-_99028874_990289420.601.5e-06Click!


Activity profile for motif Foxp1_Foxj2.

activity profile for motif Foxp1_Foxj2


Sorted Z-values histogram for motif Foxp1_Foxj2

Sorted Z-values for motif Foxp1_Foxj2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp1_Foxj2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_148444336 16.104 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr8_+_66386292 14.538 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr8_-_84773381 13.376 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr16_-_22439719 10.788 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_-_43979050 10.710 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr10_+_60106452 10.710 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr9_-_121495678 10.597 ENSMUST00000035120.4
 Cck
cholecystokinin
chr7_+_82175156 9.507 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr1_+_66386968 9.492 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr6_-_58907120 9.284 ENSMUST00000059539.3
 Nap1l5
nucleosome assembly protein 1-like 5
chr15_-_66969616 9.197 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr3_+_68584154 9.007 ENSMUST00000182997.1
 Schip1
schwannomin interacting protein 1
chr16_-_22439570 8.544 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr4_-_151108244 8.438 ENSMUST00000131948.1
 Camta1
calmodulin binding transcription activator 1
chr18_+_36952621 8.377 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr19_+_26750939 8.366 ENSMUST00000175953.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr9_-_40455670 7.721 ENSMUST00000165104.1
ENSMUST00000045682.5
 Gramd1b

GRAM domain containing 1B

chr15_+_3270767 7.627 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr13_+_16014457 7.615 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr2_+_136713444 7.539 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 384 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 26.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
4.0 20.0 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.9 17.7 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.4 17.5 GO:0006376 mRNA splice site selection(GO:0006376)
1.3 17.2 GO:0070842 aggresome assembly(GO:0070842)
0.6 16.5 GO:0018345 protein palmitoylation(GO:0018345)
0.2 16.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.0 16.1 GO:0060137 maternal process involved in parturition(GO:0060137)
1.5 14.6 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
1.2 13.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 12.7 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.2 12.4 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.9 12.1 GO:0001553 luteinization(GO:0001553)
4.0 12.0 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
1.3 11.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.6 10.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
3.4 10.3 GO:0043379 memory T cell differentiation(GO:0043379)
1.4 10.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.6 10.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
1.1 10.0 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 175 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 52.7 GO:0014069 postsynaptic density(GO:0014069)
0.1 46.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 32.0 GO:0016021 integral component of membrane(GO:0016021)
0.7 21.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 20.1 GO:0000139 Golgi membrane(GO:0000139)
0.1 18.4 GO:0097060 synaptic membrane(GO:0097060)
0.8 15.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 15.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 13.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 12.4 GO:0005802 trans-Golgi network(GO:0005802)
0.1 11.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 11.3 GO:0031941 filamentous actin(GO:0031941)
0.6 10.9 GO:0071564 npBAF complex(GO:0071564)
0.8 10.6 GO:0043203 axon hillock(GO:0043203)
0.3 10.1 GO:0035861 site of double-strand break(GO:0035861)
0.4 10.0 GO:0031430 M band(GO:0031430)
0.7 9.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.1 9.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 9.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 8.0 GO:0055038 recycling endosome membrane(GO:0055038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 265 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.9 GO:0017124 SH3 domain binding(GO:0017124)
0.3 18.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.7 18.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.7 16.5 GO:0042287 MHC protein binding(GO:0042287)
0.5 15.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 14.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 13.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 11.8 GO:0043015 gamma-tubulin binding(GO:0043015)
1.1 11.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 11.0 GO:0030507 spectrin binding(GO:0030507)
0.9 10.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
1.2 9.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.5 9.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 8.4 GO:0030246 carbohydrate binding(GO:0030246)
0.0 8.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 8.1 GO:0005509 calcium ion binding(GO:0005509)
1.1 7.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.7 7.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.0 7.8 GO:0032051 clathrin light chain binding(GO:0032051)
0.3 7.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 19.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 16.8 PID_FOXO_PATHWAY FoxO family signaling
0.3 15.7 PID_LKB1_PATHWAY LKB1 signaling events
0.5 15.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.3 13.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 12.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 10.6 PID_IL3_PATHWAY IL3-mediated signaling events
0.3 9.6 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.3 9.3 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.3 8.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 8.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.4 7.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 7.4 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 6.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
3.3 6.6 PID_INSULIN_PATHWAY Insulin Pathway
0.2 6.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 6.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 5.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.2 4.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.3 4.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 23.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.8 13.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.6 13.8 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.4 13.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.2 12.0 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 11.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.3 10.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 9.6 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.5 9.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.4 8.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.6 8.3 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
1.9 7.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 7.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 7.3 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.3 7.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.9 6.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.5 6.2 REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 Genes involved in Activated point mutants of FGFR2
0.2 5.9 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 5.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.3 5.3 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Genes involved in NRIF signals cell death from the nucleus