Motif ID: Foxp2_Foxp3

Z-value: 0.701

Transcription factors associated with Foxp2_Foxp3:

Gene SymbolEntrez IDGene Name
Foxp2 ENSMUSG00000029563.10 Foxp2
Foxp3 ENSMUSG00000039521.6 Foxp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp2mm10_v2_chr6_+_14901344_14901364-0.247.7e-02Click!
Foxp3mm10_v2_chrX_+_7579666_7579693-0.123.9e-01Click!


Activity profile for motif Foxp2_Foxp3.

activity profile for motif Foxp2_Foxp3


Sorted Z-values histogram for motif Foxp2_Foxp3

Sorted Z-values for motif Foxp2_Foxp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp2_Foxp3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_66386292 13.814 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr4_+_144892813 7.248 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 5.841 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr11_+_3332426 5.797 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr10_+_60106452 5.626 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr15_+_3270767 4.994 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr4_+_144893127 4.946 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr7_+_82175156 4.507 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr1_+_66386968 4.495 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr6_+_141524379 4.346 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr15_-_58214882 4.215 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr19_+_4855129 4.150 ENSMUST00000119694.1
 Ctsf
cathepsin F
chr2_+_28641227 4.064 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
 Tsc1


tuberous sclerosis 1


chr6_-_148444336 4.062 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr6_+_30541582 3.911 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr4_-_87806296 3.848 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr10_+_29211637 3.832 ENSMUST00000092627.4
 9330159F19Rik
RIKEN cDNA 9330159F19 gene
chr11_+_69095217 3.388 ENSMUST00000101004.2
 Per1
period circadian clock 1
chr12_-_100725028 3.292 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr8_-_84773381 3.209 ENSMUST00000109764.1
 Nfix
nuclear factor I/X

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 242 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 18.0 GO:0042572 retinol metabolic process(GO:0042572)
0.7 13.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.6 8.8 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 8.8 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.6 8.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.1 8.0 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.5 7.1 GO:0070842 aggresome assembly(GO:0070842)
2.2 6.5 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.4 6.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 5.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.6 5.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.5 5.6 GO:0097421 liver regeneration(GO:0097421)
0.5 5.1 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 5.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 4.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.6 4.7 GO:0060137 maternal process involved in parturition(GO:0060137)
0.4 4.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.4 4.2 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
1.1 4.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
1.4 4.1 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.5 14.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 11.8 GO:0014069 postsynaptic density(GO:0014069)
0.1 10.2 GO:0016605 PML body(GO:0016605)
0.2 6.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 6.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 6.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.4 5.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.6 5.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 4.9 GO:0008023 transcription elongation factor complex(GO:0008023)
1.0 4.8 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 4.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 4.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 4.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
1.4 4.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.3 4.1 GO:0030057 desmosome(GO:0030057)
1.0 4.0 GO:0044307 dendritic branch(GO:0044307)
0.3 3.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.9 3.8 GO:0031673 H zone(GO:0031673)
0.2 3.8 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 18.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.5 13.1 GO:0042287 MHC protein binding(GO:0042287)
0.0 9.9 GO:0005509 calcium ion binding(GO:0005509)
2.7 8.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 6.9 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.6 6.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 5.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 5.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.6 5.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 4.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.1 4.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 4.2 GO:0017075 syntaxin-1 binding(GO:0017075)
1.0 4.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 4.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 4.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 3.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 3.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 3.9 GO:0031402 sodium ion binding(GO:0031402)
0.5 3.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.4 3.7 GO:0035374 chondroitin sulfate binding(GO:0035374)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 10.4 PID_FOXO_PATHWAY FoxO family signaling
0.2 9.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 9.2 PID_LKB1_PATHWAY LKB1 signaling events
0.2 5.6 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 5.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 4.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 4.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 4.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 3.5 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.2 3.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.5 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 2.5 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 2.2 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.9 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 1.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 5.8 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 5.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 5.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 4.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 4.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 4.3 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 4.3 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.3 4.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 4.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 4.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 3.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.3 3.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.8 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.7 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 2.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.9 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.1 1.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation