Motif ID: Gata2_Gata1

Z-value: 0.700

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata2mm10_v2_chr6_+_88198656_881986750.482.2e-04Click!
Gata1mm10_v2_chrX_-_7967817_79679100.238.6e-02Click!


Activity profile for motif Gata2_Gata1.

activity profile for motif Gata2_Gata1


Sorted Z-values histogram for motif Gata2_Gata1

Sorted Z-values for motif Gata2_Gata1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

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Top targets:


Showing 1 to 20 of 158 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_116309639 5.652 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr16_+_45093611 5.206 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr16_+_45094036 5.186 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr11_+_90030295 4.249 ENSMUST00000092788.3
 Tmem100
transmembrane protein 100
chr8_+_84701430 3.695 ENSMUST00000037165.4
 Lyl1
lymphoblastomic leukemia 1
chr1_-_162866502 3.589 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr2_+_72476159 3.550 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr7_-_4522427 3.459 ENSMUST00000098859.3
 Tnni3
troponin I, cardiac 3
chr2_+_72476225 3.257 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr3_+_135825788 2.723 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr4_+_11579647 2.645 ENSMUST00000180239.1
 Fsbp
fibrinogen silencer binding protein
chr14_-_54577578 2.616 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr3_-_154330543 2.584 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr2_-_36104060 2.502 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr1_+_172341197 2.480 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr7_-_139582790 2.470 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr16_-_95459245 2.251 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
 Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr6_+_17306335 2.101 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr7_-_4522794 2.052 ENSMUST00000140424.1
 Tnni3
troponin I, cardiac 3
chr9_-_32541589 2.007 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.6 6.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
1.9 5.7 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.9 5.5 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.5 3.7 GO:0001955 blood vessel maturation(GO:0001955)
0.3 3.6 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.3 3.5 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.5 3.4 GO:0019532 oxalate transport(GO:0019532)
0.6 2.9 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.4 2.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.6 2.5 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.4 2.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.4 2.5 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 2.5 GO:0030168 platelet activation(GO:0030168)
0.5 2.3 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.1 2.0 GO:0035855 megakaryocyte development(GO:0035855)
0.1 2.0 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.6 1.9 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 1.9 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.6 1.7 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 9.4 GO:0005614 interstitial matrix(GO:0005614)
1.4 5.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 4.2 GO:0043204 perikaryon(GO:0043204)
0.2 2.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.4 2.6 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 2.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 2.4 GO:0097449 astrocyte projection(GO:0097449)
0.1 2.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.6 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.3 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.2 1.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.5 GO:0098533 ATPase dependent transmembrane transport complex(GO:0098533)
0.1 0.4 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 6.7 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 5.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.8 5.5 GO:0030172 troponin C binding(GO:0030172)
0.0 3.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 3.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 3.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 3.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.6 2.9 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.2 2.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.8 2.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 2.4 GO:0035591 signaling adaptor activity(GO:0035591)
0.1 2.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 1.9 GO:0016936 galactoside binding(GO:0016936)
0.1 1.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.9 GO:0005179 hormone activity(GO:0005179)
0.6 1.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 1.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.5 1.6 GO:0004531 deoxyribonuclease II activity(GO:0004531)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 6.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.9 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 2.0 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.4 5.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 4.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.2 3.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 3.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 2.4 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 2.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.8 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.6 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.1 0.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.8 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 0.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.5 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules