Motif ID: Gata3

Z-value: 1.630


Transcription factors associated with Gata3:

Gene SymbolEntrez IDGene Name
Gata3 ENSMUSG00000015619.10 Gata3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata3mm10_v2_chr2_-_9878580_9878607-0.257.1e-02Click!


Activity profile for motif Gata3.

activity profile for motif Gata3


Sorted Z-values histogram for motif Gata3

Sorted Z-values for motif Gata3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_119053339 11.150 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr6_-_23248264 8.888 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_-_119053619 7.507 ENSMUST00000062483.8
 Gli2
GLI-Kruppel family member GLI2
chr3_+_102010138 7.222 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr14_+_67234620 6.724 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr1_+_6730051 6.338 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr4_+_9269285 6.147 ENSMUST00000038841.7
 Clvs1
clavesin 1
chr4_+_148041172 5.874 ENSMUST00000069604.8
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr9_+_65265173 5.336 ENSMUST00000048762.1
 Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr14_+_13453937 5.289 ENSMUST00000153954.1
 Synpr
synaptoporin
chr11_+_102604370 5.163 ENSMUST00000057893.5
 Fzd2
frizzled homolog 2 (Drosophila)
chr7_-_103853199 5.032 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr11_+_32276400 5.007 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr19_+_41482632 4.824 ENSMUST00000067795.5
 Lcor
ligand dependent nuclear receptor corepressor
chr11_-_100527862 4.806 ENSMUST00000107385.1
 Acly
ATP citrate lyase
chr16_-_50432340 4.804 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
 Bbx




bobby sox homolog (Drosophila)




chr1_+_6730135 4.790 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr15_-_75747922 4.749 ENSMUST00000062002.4
 Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
chr7_-_37772868 4.746 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr6_-_48840988 4.619 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 384 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 20.8 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
4.7 18.7 GO:0060032 notochord regression(GO:0060032)
3.6 18.2 GO:0015671 oxygen transport(GO:0015671)
1.2 13.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 9.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.8 9.3 GO:0060539 diaphragm development(GO:0060539)
0.5 9.2 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
2.3 9.0 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.8 9.0 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.6 8.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.5 8.1 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.3 7.8 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
1.2 7.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.3 6.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.6 6.4 GO:0070829 heterochromatin maintenance(GO:0070829)
0.9 6.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 6.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.5 6.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.4 5.8 GO:0060013 righting reflex(GO:0060013)
1.9 5.6 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 19.0 GO:0097542 ciliary tip(GO:0097542)
1.7 13.7 GO:0005833 hemoglobin complex(GO:0005833)
0.0 11.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 11.2 GO:0032993 protein-DNA complex(GO:0032993)
0.2 9.1 GO:0008180 COP9 signalosome(GO:0008180)
0.2 8.5 GO:0035371 microtubule plus-end(GO:0035371)
0.3 8.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 7.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 7.0 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 6.6 GO:0060077 inhibitory synapse(GO:0060077)
0.1 6.2 GO:0005925 focal adhesion(GO:0005925)
0.1 5.7 GO:0002102 podosome(GO:0002102)
0.0 5.5 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 5.3 GO:0072562 blood microparticle(GO:0072562)
0.3 5.0 GO:0042788 polysomal ribosome(GO:0042788)
0.5 4.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 4.7 GO:0043679 axon terminus(GO:0043679)
0.1 3.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.7 GO:0055037 recycling endosome(GO:0055037)
0.2 3.3 GO:0035253 ciliary rootlet(GO:0035253)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 249 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 18.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 18.3 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
3.6 18.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 15.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 10.7 GO:0001047 core promoter binding(GO:0001047)
0.0 9.3 GO:0019904 protein domain specific binding(GO:0019904)
0.5 8.3 GO:0051010 microtubule plus-end binding(GO:0051010)
1.3 8.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 7.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.4 7.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 7.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.7 6.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.0 5.9 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 5.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 5.7 GO:0017091 AU-rich element binding(GO:0017091)
0.3 5.6 GO:0001848 complement binding(GO:0001848)
0.3 5.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 5.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 5.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 5.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 20.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 9.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 7.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 6.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 5.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 5.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 5.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 4.9 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 3.8 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 3.8 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.4 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 3.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.6 3.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 3.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.1 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 3.1 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 2.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 2.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 2.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.6 REACTOME_KINESINS Genes involved in Kinesins
0.3 9.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 7.1 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 6.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 6.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 6.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.6 6.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 5.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 5.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 5.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 4.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 4.7 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 4.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 4.0 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 3.9 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 3.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.5 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway