Motif ID: Gata4

Z-value: 0.559


Transcription factors associated with Gata4:

Gene SymbolEntrez IDGene Name
Gata4 ENSMUSG00000021944.9 Gata4



Activity profile for motif Gata4.

activity profile for motif Gata4


Sorted Z-values histogram for motif Gata4

Sorted Z-values for motif Gata4



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata4

PNG image of the network

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Top targets:


Showing 1 to 20 of 131 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_103510874 4.488 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr1_-_56969864 3.213 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 3.129 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr10_-_62342674 2.918 ENSMUST00000143179.1
ENSMUST00000130422.1
 Hk1

hexokinase 1

chr1_+_177444653 2.697 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr5_-_73191848 2.580 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr2_+_4559742 2.507 ENSMUST00000176828.1
 Frmd4a
FERM domain containing 4A
chr10_+_84576626 2.155 ENSMUST00000020223.7
 Tcp11l2
t-complex 11 (mouse) like 2
chr13_+_42709482 2.040 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr11_+_3330781 2.001 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr1_+_45311538 1.986 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr2_-_52558539 1.868 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr18_+_36952621 1.800 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr11_+_3330401 1.795 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_-_33087169 1.742 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr13_+_42681513 1.712 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr15_+_60822947 1.658 ENSMUST00000180730.1
 9930014A18Rik
RIKEN cDNA 9930014A18 gene
chr1_+_180851131 1.647 ENSMUST00000038091.6
 Sde2
SDE2 telomere maintenance homolog (S. pombe)
chr16_-_34262830 1.580 ENSMUST00000114947.1
 Kalrn
kalirin, RhoGEF kinase
chr16_-_34263179 1.579 ENSMUST00000114949.1
ENSMUST00000114954.1
 Kalrn

kalirin, RhoGEF kinase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 4.5 GO:0035640 exploration behavior(GO:0035640)
0.5 4.2 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.5 3.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 3.8 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.3 3.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 3.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 3.5 GO:0021766 hippocampus development(GO:0021766)
0.0 3.1 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.4 2.9 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 2.6 GO:0090527 actin filament reorganization(GO:0090527)
0.2 2.5 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 2.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 2.5 GO:0001541 ovarian follicle development(GO:0001541)
0.1 2.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 2.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.4 2.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 1.9 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 1.7 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.4 1.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.9 GO:0097228 sperm principal piece(GO:0097228)
0.1 2.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.3 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.7 GO:0016605 PML body(GO:0016605)
0.1 1.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.5 GO:0030139 endocytic vesicle(GO:0030139)
0.3 1.4 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 1.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.4 GO:0031143 pseudopodium(GO:0031143)
0.3 1.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 1.2 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 1.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 0.9 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 GO:0002020 protease binding(GO:0002020)
0.1 4.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.3 3.8 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 3.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 3.8 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.6 2.9 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 2.9 GO:0017124 SH3 domain binding(GO:0017124)
0.5 2.5 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 2.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 2.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.9 GO:0060090 binding, bridging(GO:0060090)
0.0 1.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 1.4 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.5 1.4 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 1.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 1.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.3 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 2.5 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.4 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 0.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.4 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 3.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.9 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 2.7 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 2.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 2.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.5 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 1.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 1.4 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.4 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 1.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.8 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP