Motif ID: Gata5

Z-value: 0.773


Transcription factors associated with Gata5:

Gene SymbolEntrez IDGene Name
Gata5 ENSMUSG00000015627.5 Gata5



Activity profile for motif Gata5.

activity profile for motif Gata5


Sorted Z-values histogram for motif Gata5

Sorted Z-values for motif Gata5



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata5

PNG image of the network

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Top targets:


Showing 1 to 20 of 133 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103853199 11.995 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr11_+_32276893 6.513 ENSMUST00000145569.1
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276400 6.240 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr14_+_75455957 4.259 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr16_-_44558879 4.136 ENSMUST00000114634.1
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr11_+_95337012 3.927 ENSMUST00000037502.6
 Fam117a
family with sequence similarity 117, member A
chr8_+_45658666 3.818 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr13_+_108316332 3.755 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr8_+_45658273 3.273 ENSMUST00000153798.1
 Sorbs2
sorbin and SH3 domain containing 2
chr16_-_50432340 3.141 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
 Bbx




bobby sox homolog (Drosophila)




chr13_+_108316395 2.878 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr7_-_70366735 2.440 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr10_-_92162753 2.330 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr5_+_93093428 2.175 ENSMUST00000074733.7
 Sept11
septin 11
chr7_+_67647405 2.137 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr11_-_101551837 1.971 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr16_-_50330987 1.882 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)
chr8_+_53511695 1.776 ENSMUST00000033920.4
 Aga
aspartylglucosaminidase
chr7_-_99238564 1.620 ENSMUST00000064231.7
 Mogat2
monoacylglycerol O-acyltransferase 2
chr3_+_146121655 1.616 ENSMUST00000039450.4
 Mcoln3
mucolipin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 24.7 GO:0015671 oxygen transport(GO:0015671)
0.2 8.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 5.6 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.0 5.0 GO:0060348 bone development(GO:0060348)
0.9 4.3 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.2 4.1 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.5 2.4 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 2.2 GO:0051291 protein heterooligomerization(GO:0051291)
0.7 2.0 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 1.8 GO:0006517 protein deglycosylation(GO:0006517)
0.5 1.6 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.5 1.6 GO:0060023 soft palate development(GO:0060023)
0.0 1.6 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.0 1.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.2 1.2 GO:0035878 nail development(GO:0035878)
0.0 1.1 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1 1.0 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.9 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 0.8 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 22.0 GO:0005833 hemoglobin complex(GO:0005833)
0.0 6.3 GO:0014069 postsynaptic density(GO:0014069)
0.1 4.1 GO:0044295 axonal growth cone(GO:0044295)
0.3 2.0 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 1.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.1 0.9 GO:0036038 MKS complex(GO:0036038)
0.1 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.9 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.6 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.5 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.4 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.4 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 0.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 24.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 5.8 GO:0005096 GTPase activator activity(GO:0005096)
0.2 2.7 GO:0016805 dipeptidase activity(GO:0016805)
0.2 2.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 2.0 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.8 GO:0043621 protein self-association(GO:0043621)
0.5 1.6 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 1.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 1.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 1.2 GO:0038132 neuregulin binding(GO:0038132)
0.4 1.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.0 1.0 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.9 GO:0005521 lamin binding(GO:0005521)
0.3 0.8 GO:0001729 ceramide kinase activity(GO:0001729)
0.2 0.7 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.7 GO:0016803 ether hydrolase activity(GO:0016803)
0.1 0.7 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 1.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.4 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 2.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.0 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.1 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 1.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.9 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.7 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.4 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling