Motif ID: Gata6

Z-value: 0.339


Transcription factors associated with Gata6:

Gene SymbolEntrez IDGene Name
Gata6 ENSMUSG00000005836.8 Gata6



Activity profile for motif Gata6.

activity profile for motif Gata6


Sorted Z-values histogram for motif Gata6

Sorted Z-values for motif Gata6



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_86732409 1.653 ENSMUST00000070435.4
 Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr11_+_67586675 1.546 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr2_+_65930117 1.258 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr6_+_58833689 1.238 ENSMUST00000041401.8
 Herc3
hect domain and RLD 3
chr12_+_95692212 1.146 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr2_+_68104671 1.115 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr10_-_62342674 1.111 ENSMUST00000143179.1
ENSMUST00000130422.1
 Hk1

hexokinase 1

chr4_+_13751297 1.067 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_+_66350465 1.049 ENSMUST00000042824.6
 Herc1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr6_+_58831748 1.003 ENSMUST00000126292.1
ENSMUST00000031823.5
 Herc3

hect domain and RLD 3

chr6_+_86078070 0.994 ENSMUST00000032069.5
 Add2
adducin 2 (beta)
chr9_-_29963112 0.987 ENSMUST00000075069.4
 Ntm
neurotrimin
chr1_+_152954966 0.971 ENSMUST00000043313.8
 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr2_-_7396192 0.737 ENSMUST00000137733.2
 Celf2
CUGBP, Elav-like family member 2
chr2_-_7081207 0.691 ENSMUST00000114923.2
ENSMUST00000182706.1
 Celf2

CUGBP, Elav-like family member 2

chr1_-_25829511 0.671 ENSMUST00000135518.1
ENSMUST00000151309.1
 Bai3

brain-specific angiogenesis inhibitor 3

chr5_-_73191848 0.662 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr5_+_76840597 0.648 ENSMUST00000120639.2
ENSMUST00000163347.1
ENSMUST00000121851.1
 C530008M17Rik


RIKEN cDNA C530008M17 gene


chr8_+_45628176 0.646 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr19_+_4711153 0.550 ENSMUST00000008991.6
 Sptbn2
spectrin beta, non-erythrocytic 2
chr2_-_7395879 0.547 ENSMUST00000182404.1
 Celf2
CUGBP, Elav-like family member 2
chr17_-_33713372 0.542 ENSMUST00000173392.1
 March2
membrane-associated ring finger (C3HC4) 2
chr2_-_7081256 0.516 ENSMUST00000183209.1
 Celf2
CUGBP, Elav-like family member 2
chr1_+_179803376 0.490 ENSMUST00000097454.2
 Gm10518
predicted gene 10518
chr16_-_34262945 0.488 ENSMUST00000114953.1
 Kalrn
kalirin, RhoGEF kinase
chr1_-_173333503 0.480 ENSMUST00000038227.4
 Darc
Duffy blood group, chemokine receptor
chr5_+_121777929 0.453 ENSMUST00000160821.1
 Atxn2
ataxin 2
chr15_+_18818895 0.449 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr6_-_38124568 0.432 ENSMUST00000040259.4
 Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr6_-_136875794 0.412 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr18_+_76059458 0.408 ENSMUST00000167921.1
 Zbtb7c
zinc finger and BTB domain containing 7C
chr8_-_64205970 0.407 ENSMUST00000066166.4
 Tll1
tolloid-like
chr6_-_127109517 0.389 ENSMUST00000039913.8
 9630033F20Rik
RIKEN cDNA 9630033F20 gene
chr8_+_45627709 0.386 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr8_+_45627946 0.372 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr11_+_4883186 0.359 ENSMUST00000139737.1
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr11_+_3330781 0.353 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr6_-_23248264 0.335 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_+_119900099 0.326 ENSMUST00000106516.1
 Lyrm1
LYR motif containing 1
chr2_-_59948155 0.317 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr3_-_20242173 0.285 ENSMUST00000001921.1
 Cpa3
carboxypeptidase A3, mast cell
chr2_-_33087169 0.272 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_+_80617045 0.260 ENSMUST00000028384.4
 Dusp19
dual specificity phosphatase 19
chr17_+_34604819 0.255 ENSMUST00000173242.1
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr8_-_122699066 0.252 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr2_-_7395968 0.252 ENSMUST00000002176.6
 Celf2
CUGBP, Elav-like family member 2
chr1_+_45311538 0.245 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr5_-_30461902 0.244 ENSMUST00000133509.1
ENSMUST00000074171.6
ENSMUST00000114747.2
ENSMUST00000144125.1
 Otof



otoferlin



chr16_-_46010212 0.235 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr11_+_87581041 0.221 ENSMUST00000018544.5
ENSMUST00000063156.4
ENSMUST00000107960.1
 Sept4


septin 4


chr11_+_95712673 0.214 ENSMUST00000107717.1
 Zfp652
zinc finger protein 652
chr16_+_36041184 0.214 ENSMUST00000042203.8
 Wdr5b
WD repeat domain 5B
chr2_-_33086366 0.185 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr7_-_119895446 0.182 ENSMUST00000098080.2
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr15_-_83170168 0.169 ENSMUST00000162834.1
 Cyb5r3
cytochrome b5 reductase 3
chr5_+_19907502 0.168 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chrX_-_37110257 0.154 ENSMUST00000076265.6
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr15_-_83170498 0.151 ENSMUST00000162178.1
 Cyb5r3
cytochrome b5 reductase 3
chr10_+_40883469 0.151 ENSMUST00000019975.7
 Wasf1
WAS protein family, member 1
chr16_+_58670208 0.149 ENSMUST00000060077.5
 Cpox
coproporphyrinogen oxidase
chr6_-_122609964 0.142 ENSMUST00000032211.4
 Gdf3
growth differentiation factor 3
chr17_+_71204647 0.136 ENSMUST00000126681.1
 Lpin2
lipin 2
chr11_+_4986824 0.133 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr9_-_65827544 0.132 ENSMUST00000159109.1
 Zfp609
zinc finger protein 609
chr2_+_71786923 0.123 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr10_+_52417532 0.117 ENSMUST00000023830.8
 Nus1
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
chr19_+_58670358 0.107 ENSMUST00000057270.7
 Pnlip
pancreatic lipase
chr9_+_65032413 0.099 ENSMUST00000034960.6
 Dpp8
dipeptidylpeptidase 8
chr16_+_91647859 0.096 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
 Son



Son DNA binding protein



chr4_-_46404224 0.077 ENSMUST00000107764.2
 Hemgn
hemogen
chr10_+_53337686 0.057 ENSMUST00000046221.6
ENSMUST00000163319.1
 Pln

phospholamban

chr2_+_143915273 0.049 ENSMUST00000103172.3
 Dstn
destrin
chr11_-_53707269 0.046 ENSMUST00000124352.1
ENSMUST00000020649.7
 Rad50

RAD50 homolog (S. cerevisiae)

chr11_-_103697898 0.024 ENSMUST00000021329.7
 Gosr2
golgi SNAP receptor complex member 2
chr11_-_70220969 0.015 ENSMUST00000060010.2
 Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr18_-_43477764 0.014 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.2 1.1 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 1.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 2.1 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.1 0.7 GO:0090527 actin filament reorganization(GO:0090527)
0.1 2.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.5 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 1.0 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.4 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.4 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.4 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.3 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.0 0.3 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.1 GO:0045605 negative regulation of epidermal cell differentiation(GO:0045605)
0.0 0.2 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.1 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 0.1 GO:0035878 nail development(GO:0035878)
0.0 0.2 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 1.1 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.1 GO:0032380 dolichol metabolic process(GO:0019348) regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 1.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.0 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.2 GO:0010225 response to UV-C(GO:0010225)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.6 GO:0008091 spectrin(GO:0008091)
0.1 0.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 1.1 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)
0.0 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 1.0 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.2 1.1 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.4 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 1.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 2.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.5 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.1 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.4 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation