Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.564

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx3mm10_v2_chr3_+_107595031_1075951640.114.1e-01Click!
Gbx1mm10_v2_chr5_-_24527276_24527276-0.038.1e-01Click!


Activity profile for motif Gbx1_Nobox_Alx3.

activity profile for motif Gbx1_Nobox_Alx3


Sorted Z-values histogram for motif Gbx1_Nobox_Alx3

Sorted Z-values for motif Gbx1_Nobox_Alx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_23415400 4.815 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr12_+_109545390 4.309 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chrX_-_143933089 4.156 ENSMUST00000087313.3
 Dcx
doublecortin
chr15_-_11037968 3.709 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr11_-_98053415 3.650 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr2_+_125136692 3.563 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr1_-_158356258 3.512 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr9_+_32116040 3.428 ENSMUST00000174641.1
 Arhgap32
Rho GTPase activating protein 32
chr7_+_126950518 3.296 ENSMUST00000106335.1
ENSMUST00000146017.1
 Sez6l2

seizure related 6 homolog like 2

chr3_+_55461758 3.027 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr15_+_92597104 3.007 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr4_+_108719649 2.882 ENSMUST00000178992.1
 3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr7_+_126950687 2.869 ENSMUST00000106333.1
 Sez6l2
seizure related 6 homolog like 2
chr10_+_39612934 2.838 ENSMUST00000019987.6
 Traf3ip2
TRAF3 interacting protein 2
chr16_-_42340595 2.815 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr12_-_91849081 2.760 ENSMUST00000167466.1
ENSMUST00000021347.5
ENSMUST00000178462.1
 Sel1l


sel-1 suppressor of lin-12-like (C. elegans)


chr1_+_72284367 2.733 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr9_-_55919605 2.715 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr1_-_155417394 2.589 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr6_+_125552948 2.585 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.8 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.5 6.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 5.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 5.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 4.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 3.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.4 3.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 3.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.6 3.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.4 3.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 3.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.5 3.0 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 3.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 3.0 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 3.0 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 2.9 GO:0007416 synapse assembly(GO:0007416)
0.5 2.8 GO:0016198 axon choice point recognition(GO:0016198)
0.2 2.8 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 2.8 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 2.7 GO:0030168 platelet activation(GO:0030168)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 5.9 GO:0071565 nBAF complex(GO:0071565)
0.1 5.6 GO:0031672 A band(GO:0031672)
0.0 3.5 GO:0001650 fibrillar center(GO:0001650)
0.6 2.8 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 2.8 GO:0031527 filopodium membrane(GO:0031527)
0.5 2.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.4 GO:0005882 intermediate filament(GO:0005882)
0.3 2.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 2.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 2.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 2.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.5 2.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 1.8 GO:0030673 axolemma(GO:0030673)
0.3 1.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.5 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.2 1.4 GO:0097433 dense body(GO:0097433)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.5 GO:0008017 microtubule binding(GO:0008017)
0.0 4.4 GO:0005509 calcium ion binding(GO:0005509)
0.4 4.0 GO:0019865 immunoglobulin binding(GO:0019865)
0.9 3.7 GO:0004966 galanin receptor activity(GO:0004966)
0.0 3.7 GO:0017124 SH3 domain binding(GO:0017124)
0.2 3.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 3.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.4 3.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.4 3.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 3.1 GO:0030165 PDZ domain binding(GO:0030165)
1.0 3.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 3.0 GO:0002039 p53 binding(GO:0002039)
0.0 2.8 GO:0019905 syntaxin binding(GO:0019905)
0.0 2.8 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 2.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 2.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 2.4 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.1 2.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.4 GO:0000287 magnesium ion binding(GO:0000287)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 5.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 4.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.6 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.2 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 1.1 PID_BMP_PATHWAY BMP receptor signaling
0.1 0.9 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.7 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.6 PID_P53_REGULATION_PATHWAY p53 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 5.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 4.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 2.6 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 2.5 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.1 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 1.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.0 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 1.0 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers