Motif ID: Gbx2

Z-value: 0.559


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_89933290-0.095.3e-01Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 55 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_59170978 7.239 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr3_-_116129615 6.767 ENSMUST00000029574.8
Vcam1
vascular cell adhesion molecule 1
chr13_-_97747373 4.149 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_36784924 4.027 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr14_-_48667508 3.851 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr3_+_94372794 3.739 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr12_+_79297345 3.563 ENSMUST00000079533.5
ENSMUST00000171210.1
Rad51b

RAD51 homolog B

chrX_+_106920618 3.307 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr16_-_36784784 3.086 ENSMUST00000165531.1
Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chrM_-_14060 2.677 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr13_-_97747399 2.240 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_+_59306920 2.063 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr7_-_30664986 2.058 ENSMUST00000019697.8
Haus5
HAUS augmin-like complex, subunit 5
chr7_+_75455534 1.962 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13

A kinase (PRKA) anchor protein 13

chr4_+_110397661 1.771 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
Agbl4



ATP/GTP binding protein-like 4



chr18_+_56432116 1.716 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr1_-_128102412 1.636 ENSMUST00000112538.1
ENSMUST00000086614.5
Zranb3

zinc finger, RAN-binding domain containing 3

chr5_-_111761697 1.500 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr4_+_110397764 1.446 ENSMUST00000097920.2
ENSMUST00000080744.6
Agbl4

ATP/GTP binding protein-like 4

chr9_+_96258697 1.353 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.2 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
1.4 7.1 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
0.6 6.8 GO:0061032 visceral serous pericardium development(GO:0061032)
1.0 3.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 3.7 GO:0072615 interleukin-17 secretion(GO:0072615)
0.6 3.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.2 3.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.8 3.2 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 2.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 2.1 GO:0051225 spindle assembly(GO:0051225)
0.3 2.0 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.5 1.6 GO:0036292 DNA rewinding(GO:0036292)
0.0 1.3 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.1 1.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.1 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.2 0.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.9 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 0.7 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.7 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.6 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.5 GO:0002102 podosome(GO:0002102)
0.0 4.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.7 3.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 3.2 GO:0005814 centriole(GO:0005814)
0.0 2.9 GO:0030426 growth cone(GO:0030426)
0.0 2.6 GO:0070469 respiratory chain(GO:0070469)
0.3 2.1 GO:0070652 HAUS complex(GO:0070652)
0.0 2.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.6 GO:0043596 nuclear replication fork(GO:0043596)
0.0 1.3 GO:0000786 nucleosome(GO:0000786)
0.4 1.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.9 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
2.4 7.1 GO:0042936 dipeptide transporter activity(GO:0042936)
1.7 6.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 3.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.9 3.7 GO:0008142 oxysterol binding(GO:0008142)
0.5 3.6 GO:0000150 recombinase activity(GO:0000150)
0.5 3.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 3.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.1 GO:0005109 frizzled binding(GO:0005109)
0.2 2.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.6 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.3 GO:0008201 heparin binding(GO:0008201)
0.1 1.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 0.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.7 GO:0005518 collagen binding(GO:0005518)
0.2 0.6 GO:0019966 interleukin-1 binding(GO:0019966)
0.2 0.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 3.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 2.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 2.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 0.9 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 6.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 3.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 2.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.1 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.9 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.4 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling