Motif ID: Gcm1

Z-value: 0.441


Transcription factors associated with Gcm1:

Gene SymbolEntrez IDGene Name
Gcm1 ENSMUSG00000023333.7 Gcm1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gcm1mm10_v2_chr9_+_78051938_780519580.038.0e-01Click!


Activity profile for motif Gcm1.

activity profile for motif Gcm1


Sorted Z-values histogram for motif Gcm1

Sorted Z-values for motif Gcm1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gcm1

PNG image of the network

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Top targets:


Showing 1 to 20 of 56 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065538 3.496 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr19_+_6400523 2.413 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr11_+_101246960 2.320 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr5_-_110343009 2.173 ENSMUST00000058016.9
ENSMUST00000112478.3
 P2rx2

purinergic receptor P2X, ligand-gated ion channel, 2

chrX_+_73503074 1.877 ENSMUST00000114479.1
ENSMUST00000088429.1
ENSMUST00000033744.5
 Atp2b3


ATPase, Ca++ transporting, plasma membrane 3


chr7_-_99182681 1.726 ENSMUST00000033001.4
 Dgat2
diacylglycerol O-acyltransferase 2
chr4_-_136956784 1.712 ENSMUST00000030420.8
 Epha8
Eph receptor A8
chr3_-_69598822 1.401 ENSMUST00000061826.1
 B3galnt1
UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1
chr12_-_119238794 1.391 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr7_+_46396439 1.385 ENSMUST00000025202.6
 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr14_-_19977249 1.242 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_66213552 1.049 ENSMUST00000178730.1
 Ptk2b
PTK2 protein tyrosine kinase 2 beta
chr16_-_3907651 1.035 ENSMUST00000177221.1
ENSMUST00000177323.1
 1700037C18Rik

RIKEN cDNA 1700037C18 gene

chr7_+_119900099 1.017 ENSMUST00000106516.1
 Lyrm1
LYR motif containing 1
chr6_-_113501818 0.960 ENSMUST00000101059.1
 Prrt3
proline-rich transmembrane protein 3
chr19_+_6400611 0.956 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr10_-_13868779 0.885 ENSMUST00000105534.3
 Aig1
androgen-induced 1
chr16_-_91597636 0.848 ENSMUST00000023686.8
 Tmem50b
transmembrane protein 50B
chr2_+_96318014 0.841 ENSMUST00000135431.1
ENSMUST00000162807.2
 Lrrc4c

leucine rich repeat containing 4C

chr17_+_8311101 0.781 ENSMUST00000154553.1
 Sft2d1
SFT2 domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.5 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.1 3.4 GO:0071277 cellular response to calcium ion(GO:0071277)
0.4 2.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 2.2 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
0.4 1.9 GO:1990034 calcium ion export from cell(GO:1990034)
0.3 1.7 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.2 1.7 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 1.4 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 1.4 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 1.4 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.3 1.0 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
0.0 0.8 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.7 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.0 0.7 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.3 0.6 GO:0035106 operant conditioning(GO:0035106)
0.1 0.6 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0 0.5 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 0.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.3 GO:0042713 sperm ejaculation(GO:0042713)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0051233 spindle midzone(GO:0051233)
0.5 2.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 2.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.7 GO:0005811 lipid particle(GO:0005811)
0.1 1.4 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 1.4 GO:0030673 axolemma(GO:0030673) dendrite membrane(GO:0032590)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.5 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.3 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0043274 phospholipase binding(GO:0043274)
0.0 3.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.5 2.3 GO:0097643 amylin receptor activity(GO:0097643)
0.4 2.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) mercury ion binding(GO:0045340)
0.1 1.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.6 1.7 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.2 1.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 1.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.2 1.4 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 1.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 1.0 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.3 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 1.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 1.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.5 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 3.4 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.9 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.7 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.0 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL