Motif ID: Gcm2

Z-value: 2.029


Transcription factors associated with Gcm2:

Gene SymbolEntrez IDGene Name
Gcm2 ENSMUSG00000021362.6 Gcm2



Activity profile for motif Gcm2.

activity profile for motif Gcm2


Sorted Z-values histogram for motif Gcm2

Sorted Z-values for motif Gcm2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gcm2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065737 48.676 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr11_-_6065538 28.778 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr15_-_66831625 23.968 ENSMUST00000164163.1
 Sla
src-like adaptor
chr7_+_121392266 20.070 ENSMUST00000084628.3
 Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr4_-_138396438 16.111 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr12_-_79007276 14.569 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B

chr2_-_32353247 13.767 ENSMUST00000078352.5
ENSMUST00000113352.2
ENSMUST00000113365.1
 Dnm1


dynamin 1


chr9_+_112234257 11.663 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr15_-_44788016 11.579 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr19_+_6400523 11.464 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr7_+_57591147 11.358 ENSMUST00000039697.7
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr5_+_110544326 10.844 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr11_+_98348404 9.841 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr2_-_32353283 9.555 ENSMUST00000091089.5
ENSMUST00000113350.1
 Dnm1

dynamin 1

chr4_+_85205120 9.281 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr1_+_50927511 9.253 ENSMUST00000081851.3
 Tmeff2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr2_+_82053222 9.166 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr5_-_37717122 8.897 ENSMUST00000094836.4
 Stk32b
serine/threonine kinase 32B
chr15_+_25414175 8.484 ENSMUST00000069992.5
 Gm5468
predicted gene 5468
chr3_+_96596628 8.324 ENSMUST00000058943.7
 Ankrd34a
ankyrin repeat domain 34A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 486 entries
Log-likelihood per target Total log-likelihoodTermDescription
25.8 77.5 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
3.3 23.3 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.3 20.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.6 15.9 GO:0071625 vocalization behavior(GO:0071625)
0.3 14.5 GO:0001881 receptor recycling(GO:0001881)
0.3 14.1 GO:0034605 cellular response to heat(GO:0034605)
0.2 12.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.6 11.9 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.6 11.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.3 11.4 GO:0071420 cellular response to histamine(GO:0071420)
0.3 11.2 GO:0071277 cellular response to calcium ion(GO:0071277)
1.6 11.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.5 10.7 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.4 10.4 GO:0048148 behavioral response to cocaine(GO:0048148)
0.5 10.1 GO:0001553 luteinization(GO:0001553)
3.3 9.8 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 9.7 GO:0008654 phospholipid biosynthetic process(GO:0008654)
2.3 9.3 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
1.9 9.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.2 8.5 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 192 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 111.0 GO:0016021 integral component of membrane(GO:0016021)
1.9 65.6 GO:0051233 spindle midzone(GO:0051233)
0.2 44.5 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
2.3 36.5 GO:0043196 varicosity(GO:0043196)
0.2 28.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 25.0 GO:0031225 anchored component of membrane(GO:0031225)
0.2 24.5 GO:0008021 synaptic vesicle(GO:0008021)
0.3 24.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.5 21.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 19.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 16.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 16.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
1.0 15.0 GO:0043083 synaptic cleft(GO:0043083)
1.7 13.7 GO:0097433 dense body(GO:0097433)
0.1 12.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 11.9 GO:0043025 neuronal cell body(GO:0043025)
0.8 11.4 GO:1902711 GABA-A receptor complex(GO:1902711)
1.0 11.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
1.8 10.6 GO:0008091 spectrin(GO:0008091)
0.3 9.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 314 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 81.8 GO:0043274 phospholipase binding(GO:0043274)
3.3 33.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 25.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
1.3 25.0 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.6 20.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 17.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
1.2 15.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.5 14.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 13.9 GO:0008289 lipid binding(GO:0008289)
0.4 12.6 GO:0017046 peptide hormone binding(GO:0017046)
1.9 11.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
1.5 10.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.5 10.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 10.1 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 10.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 9.7 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 9.7 GO:0005516 calmodulin binding(GO:0005516)
1.8 9.1 GO:0034235 GPI anchor binding(GO:0034235)
0.1 8.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 8.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 81.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.7 28.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.2 18.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 17.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 14.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 12.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.6 8.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 8.6 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.2 8.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 8.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 6.5 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.5 6.4 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.2 5.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 5.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 5.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 4.9 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.2 4.8 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 4.6 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.2 4.1 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.5 3.9 PID_IL2_1PATHWAY IL2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 92.6 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.6 32.6 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.7 23.3 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.5 21.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.5 18.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 17.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.5 14.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 12.0 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
1.2 11.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.7 11.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 10.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.6 9.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 8.4 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 8.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.4 7.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 7.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 7.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
1.1 6.6 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.3 6.6 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.3 6.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation