Motif ID: Gfi1_Gfi1b

Z-value: 1.189

Transcription factors associated with Gfi1_Gfi1b:

Gene SymbolEntrez IDGene Name
Gfi1 ENSMUSG00000029275.11 Gfi1
Gfi1b ENSMUSG00000026815.8 Gfi1b



Activity profile for motif Gfi1_Gfi1b.

activity profile for motif Gfi1_Gfi1b


Sorted Z-values histogram for motif Gfi1_Gfi1b

Sorted Z-values for motif Gfi1_Gfi1b



Network of associatons between targets according to the STRING database.



First level regulatory network of Gfi1_Gfi1b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 15.994 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_-_26989974 9.866 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr7_+_62376979 7.763 ENSMUST00000080403.5
 Magel2
melanoma antigen, family L, 2
chr9_+_3027439 6.402 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3005125 6.147 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3000922 6.122 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3013140 5.591 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3034599 5.585 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr7_-_17062384 5.163 ENSMUST00000153833.1
ENSMUST00000108492.2
 Hif3a

hypoxia inducible factor 3, alpha subunit

chr9_+_3023547 5.035 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3017408 5.016 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 4.875 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3025417 4.858 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr13_+_35659856 4.487 ENSMUST00000075220.6
 Cdyl
chromodomain protein, Y chromosome-like
chr9_+_3037111 4.369 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr10_+_13090788 4.216 ENSMUST00000121646.1
ENSMUST00000121325.1
ENSMUST00000121766.1
 Plagl1


pleiomorphic adenoma gene-like 1


chr9_+_3036877 4.210 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr7_-_62464505 4.187 ENSMUST00000094339.2
 Peg12
paternally expressed 12
chr9_+_3004457 3.684 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr12_+_109544498 3.668 ENSMUST00000126289.1
 Meg3
maternally expressed 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 16.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 11.3 GO:0006270 DNA replication initiation(GO:0006270)
0.6 7.8 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.2 4.9 GO:0008340 determination of adult lifespan(GO:0008340)
1.2 4.7 GO:2000768 positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.1 4.2 GO:0000578 embryonic axis specification(GO:0000578)
0.1 4.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.3 3.8 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 3.6 GO:0001525 angiogenesis(GO:0001525)
0.1 3.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.1 3.2 GO:0035622 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
0.2 3.0 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.2 3.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.9 2.8 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 2.8 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.9 2.7 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.1 2.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 2.6 GO:0043029 T cell homeostasis(GO:0043029)
0.4 2.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 2.5 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.9 GO:0016607 nuclear speck(GO:0016607)
0.2 7.8 GO:0030904 retromer complex(GO:0030904)
0.0 6.3 GO:0000776 kinetochore(GO:0000776)
0.1 3.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.1 GO:0016604 nuclear body(GO:0016604)
0.1 2.6 GO:0002102 podosome(GO:0002102)
0.0 2.6 GO:0030141 secretory granule(GO:0030141)
0.0 2.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 2.5 GO:0043209 myelin sheath(GO:0043209)
0.3 2.4 GO:0033269 internode region of axon(GO:0033269)
0.0 2.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 2.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 2.2 GO:0045120 pronucleus(GO:0045120)
0.0 2.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.0 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.9 GO:0016605 PML body(GO:0016605)
0.3 1.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 1.7 GO:0005883 neurofilament(GO:0005883)
0.2 1.6 GO:0008278 cohesin complex(GO:0008278)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 9.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 7.0 GO:0003779 actin binding(GO:0003779)
0.0 6.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 6.1 GO:0003682 chromatin binding(GO:0003682)
0.1 5.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 4.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 4.4 GO:0035326 enhancer binding(GO:0035326)
0.0 4.1 GO:0045296 cadherin binding(GO:0045296)
0.4 4.0 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 3.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 3.0 GO:0070410 co-SMAD binding(GO:0070410)
0.9 2.8 GO:0016015 morphogen activity(GO:0016015)
0.0 2.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.9 2.7 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 2.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 2.6 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 2.4 GO:0042393 histone binding(GO:0042393)
0.0 2.4 GO:0051082 unfolded protein binding(GO:0051082)
0.3 2.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 4.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 4.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 3.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.1 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 2.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 1.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.3 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 1.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.1 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.9 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 0.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 5.2 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 4.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 3.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2 3.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 3.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 2.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 2.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 2.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 2.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 2.2 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 2.2 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.1 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 2.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.9 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.7 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.2 1.6 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1 1.6 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines