Motif ID: Gfi1_Gfi1b
Z-value: 1.189
Transcription factors associated with Gfi1_Gfi1b:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Gfi1 | ENSMUSG00000029275.11 | Gfi1 |
| Gfi1b | ENSMUSG00000026815.8 | Gfi1b |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 16.0 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 1.2 | 4.7 | GO:2000768 | positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 1.1 | 3.2 | GO:0035622 | intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034) |
| 0.9 | 2.8 | GO:1900108 | negative regulation of nodal signaling pathway(GO:1900108) |
| 0.9 | 2.7 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.8 | 1.7 | GO:1990705 | cholangiocyte proliferation(GO:1990705) |
| 0.7 | 2.2 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.7 | 2.1 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.6 | 2.4 | GO:0006166 | purine ribonucleoside salvage(GO:0006166) |
| 0.6 | 1.8 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.6 | 1.8 | GO:1902336 | neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336) |
| 0.6 | 1.7 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 0.6 | 7.8 | GO:0051127 | positive regulation of actin nucleation(GO:0051127) |
| 0.5 | 1.5 | GO:0033566 | gamma-tubulin complex localization(GO:0033566) |
| 0.4 | 1.8 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.4 | 2.5 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.4 | 1.5 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.4 | 1.1 | GO:0002842 | positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.3 | 1.0 | GO:0030070 | insulin processing(GO:0030070) |
| 0.3 | 1.3 | GO:1900623 | positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.3 | 1.0 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.3 | 3.8 | GO:0021798 | forebrain dorsal/ventral pattern formation(GO:0021798) |
| 0.3 | 1.6 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 0.3 | 1.2 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.3 | 0.9 | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448) rRNA export from nucleus(GO:0006407) |
| 0.3 | 1.2 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.3 | 1.2 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) general adaptation syndrome(GO:0051866) |
| 0.3 | 0.6 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) |
| 0.3 | 11.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.3 | 0.3 | GO:0071335 | hair follicle cell proliferation(GO:0071335) |
| 0.3 | 0.8 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 0.3 | 0.8 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 0.3 | 0.8 | GO:0001830 | trophectodermal cell fate commitment(GO:0001830) |
| 0.3 | 1.0 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
| 0.2 | 2.5 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.2 | 1.0 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.2 | 0.7 | GO:0035523 | protein K29-linked deubiquitination(GO:0035523) protein K6-linked deubiquitination(GO:0044313) |
| 0.2 | 1.9 | GO:0014741 | negative regulation of cardiac muscle hypertrophy(GO:0010614) negative regulation of muscle hypertrophy(GO:0014741) |
| 0.2 | 1.7 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
| 0.2 | 2.1 | GO:0070141 | response to UV-A(GO:0070141) |
| 0.2 | 0.9 | GO:1900150 | neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) regulation of defense response to fungus(GO:1900150) |
| 0.2 | 0.4 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
| 0.2 | 0.7 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
| 0.2 | 0.7 | GO:1904207 | chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.2 | 1.5 | GO:0031424 | keratinization(GO:0031424) |
| 0.2 | 1.1 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.2 | 3.0 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.2 | 0.8 | GO:0097168 | condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168) |
| 0.2 | 3.0 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.2 | 0.6 | GO:0046881 | sperm ejaculation(GO:0042713) positive regulation of follicle-stimulating hormone secretion(GO:0046881) |
| 0.2 | 0.6 | GO:0097274 | urea homeostasis(GO:0097274) |
| 0.2 | 0.4 | GO:0032847 | regulation of cellular pH reduction(GO:0032847) |
| 0.2 | 4.9 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.2 | 0.2 | GO:1901630 | negative regulation of presynaptic membrane organization(GO:1901630) |
| 0.2 | 1.3 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
| 0.2 | 0.6 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 0.2 | 0.6 | GO:0060578 | extraocular skeletal muscle development(GO:0002074) subthalamic nucleus development(GO:0021763) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578) |
| 0.2 | 1.2 | GO:0055064 | carbon dioxide transport(GO:0015670) chloride ion homeostasis(GO:0055064) |
| 0.2 | 0.5 | GO:0090646 | mitochondrial tRNA processing(GO:0090646) |
| 0.1 | 0.6 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 0.1 | 2.2 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 0.6 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
| 0.1 | 0.7 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 0.1 | 2.6 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 0.5 | GO:0035989 | tendon development(GO:0035989) |
| 0.1 | 0.4 | GO:0002940 | tRNA N2-guanine methylation(GO:0002940) |
| 0.1 | 1.2 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.1 | 1.8 | GO:0060013 | righting reflex(GO:0060013) |
| 0.1 | 0.5 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.1 | 1.4 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.1 | 2.1 | GO:0030903 | notochord development(GO:0030903) |
| 0.1 | 0.5 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.1 | 1.6 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
| 0.1 | 0.4 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.1 | 1.2 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.1 | 0.9 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.1 | 0.3 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
| 0.1 | 0.6 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.1 | 4.2 | GO:0000578 | embryonic axis specification(GO:0000578) |
| 0.1 | 3.3 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.1 | 0.6 | GO:1901979 | regulation of inward rectifier potassium channel activity(GO:1901979) |
| 0.1 | 0.6 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.1 | 1.3 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.1 | 0.3 | GO:0019255 | glucose 1-phosphate metabolic process(GO:0019255) |
| 0.1 | 0.6 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 0.6 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 1.8 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.1 | 0.8 | GO:0060046 | regulation of acrosome reaction(GO:0060046) |
| 0.1 | 0.6 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.1 | 0.4 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
| 0.1 | 1.2 | GO:0033005 | positive regulation of mast cell activation(GO:0033005) positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 0.1 | 0.2 | GO:0071873 | response to norepinephrine(GO:0071873) |
| 0.1 | 0.3 | GO:0072086 | specification of loop of Henle identity(GO:0072086) |
| 0.1 | 0.3 | GO:0010520 | regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.1 | 0.3 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.1 | 0.6 | GO:0016114 | terpenoid biosynthetic process(GO:0016114) |
| 0.1 | 0.4 | GO:0007182 | common-partner SMAD protein phosphorylation(GO:0007182) |
| 0.1 | 0.2 | GO:0070172 | positive regulation of tooth mineralization(GO:0070172) |
| 0.1 | 0.2 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.1 | 0.6 | GO:1900016 | negative regulation of cytokine production involved in inflammatory response(GO:1900016) |
| 0.1 | 0.3 | GO:0030576 | Cajal body organization(GO:0030576) |
| 0.1 | 0.2 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.1 | 0.8 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 0.2 | GO:0045414 | regulation of interleukin-8 biosynthetic process(GO:0045414) |
| 0.1 | 0.4 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.1 | 0.2 | GO:0032240 | RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.1 | 0.7 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.1 | 0.1 | GO:0060298 | positive regulation of sarcomere organization(GO:0060298) |
| 0.1 | 0.4 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.1 | 0.3 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
| 0.1 | 0.6 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804) |
| 0.1 | 1.7 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.1 | 0.4 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.1 | 0.4 | GO:0015842 | aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) |
| 0.1 | 0.4 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.1 | 0.7 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 0.8 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.1 | 0.4 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.1 | 2.6 | GO:0043029 | T cell homeostasis(GO:0043029) |
| 0.1 | 4.2 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 1.0 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.1 | 0.7 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.1 | 2.8 | GO:0050830 | defense response to Gram-positive bacterium(GO:0050830) |
| 0.1 | 0.3 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) |
| 0.1 | 1.1 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.1 | 0.3 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) |
| 0.1 | 0.4 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.0 | 0.1 | GO:0050883 | musculoskeletal movement, spinal reflex action(GO:0050883) |
| 0.0 | 0.1 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.0 | 1.3 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.5 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.5 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.0 | 0.6 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
| 0.0 | 0.3 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.0 | 1.2 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 2.3 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
| 0.0 | 0.4 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 0.0 | 0.6 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.1 | GO:0038145 | macrophage colony-stimulating factor signaling pathway(GO:0038145) |
| 0.0 | 1.0 | GO:0019432 | triglyceride biosynthetic process(GO:0019432) |
| 0.0 | 2.0 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
| 0.0 | 0.1 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.0 | 0.4 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.0 | 0.1 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.0 | 0.2 | GO:0031442 | positive regulation of mRNA 3'-end processing(GO:0031442) |
| 0.0 | 0.1 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
| 0.0 | 1.8 | GO:0021884 | forebrain neuron development(GO:0021884) |
| 0.0 | 0.7 | GO:0007413 | axonal fasciculation(GO:0007413) |
| 0.0 | 0.2 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 0.0 | 0.2 | GO:0018377 | N-terminal protein myristoylation(GO:0006499) protein myristoylation(GO:0018377) |
| 0.0 | 0.1 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.0 | 1.0 | GO:0051310 | metaphase plate congression(GO:0051310) |
| 0.0 | 1.3 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.1 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.0 | 0.2 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.0 | 0.1 | GO:0036363 | transforming growth factor beta activation(GO:0036363) |
| 0.0 | 0.1 | GO:0015793 | glycerol transport(GO:0015793) renal water absorption(GO:0070295) |
| 0.0 | 1.5 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 0.3 | GO:0090331 | negative regulation of platelet aggregation(GO:0090331) |
| 0.0 | 0.1 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
| 0.0 | 0.1 | GO:0042795 | snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 0.1 | GO:0002572 | pro-T cell differentiation(GO:0002572) |
| 0.0 | 0.3 | GO:0042403 | thyroid hormone metabolic process(GO:0042403) |
| 0.0 | 0.3 | GO:1903894 | regulation of IRE1-mediated unfolded protein response(GO:1903894) |
| 0.0 | 0.3 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.0 | 1.0 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.2 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.0 | 0.1 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.0 | 0.1 | GO:0046549 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.0 | 0.2 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.0 | 1.3 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 0.7 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.3 | GO:0009081 | branched-chain amino acid metabolic process(GO:0009081) branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 0.5 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.0 | 0.8 | GO:1901381 | positive regulation of potassium ion transmembrane transport(GO:1901381) |
| 0.0 | 2.0 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 0.9 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.0 | 0.3 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 0.3 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 0.3 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.0 | 0.4 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.0 | 0.1 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.0 | 0.3 | GO:0051968 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) |
| 0.0 | 0.6 | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle(GO:0007091) metaphase/anaphase transition of cell cycle(GO:0044784) |
| 0.0 | 0.5 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.0 | 0.2 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.0 | 0.3 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.0 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.0 | 0.8 | GO:0050679 | positive regulation of epithelial cell proliferation(GO:0050679) |
| 0.0 | 0.2 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.0 | 0.2 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 0.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.7 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 0.2 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.0 | 0.1 | GO:0034644 | cellular response to UV(GO:0034644) |
| 0.0 | 0.2 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 1.2 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.1 | GO:0061085 | regulation of histone H3-K27 methylation(GO:0061085) positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.0 | 0.3 | GO:0006760 | folic acid-containing compound metabolic process(GO:0006760) |
| 0.0 | 0.3 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.0 | 0.0 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.0 | 0.0 | GO:0045648 | positive regulation of erythrocyte differentiation(GO:0045648) |
| 0.0 | 0.2 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 1.1 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity(GO:0051092) |
| 0.0 | 0.2 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 0.3 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 0.9 | GO:0051963 | regulation of synapse assembly(GO:0051963) |
| 0.0 | 3.6 | GO:0001525 | angiogenesis(GO:0001525) |
| 0.0 | 1.6 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.0 | GO:0002309 | T cell proliferation involved in immune response(GO:0002309) interleukin-3 production(GO:0032632) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0071914 | prominosome(GO:0071914) |
| 0.3 | 1.3 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 0.3 | 1.8 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.3 | 2.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.3 | 1.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.2 | 1.6 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.2 | 0.7 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.2 | 7.8 | GO:0030904 | retromer complex(GO:0030904) |
| 0.2 | 1.7 | GO:0005883 | neurofilament(GO:0005883) |
| 0.2 | 1.4 | GO:0042627 | chylomicron(GO:0042627) |
| 0.2 | 1.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.2 | 0.6 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.2 | 0.6 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.2 | 1.5 | GO:0001520 | outer dense fiber(GO:0001520) meiotic spindle(GO:0072687) |
| 0.2 | 0.9 | GO:0001652 | granular component(GO:0001652) |
| 0.2 | 0.3 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 0.2 | 0.9 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.1 | 0.4 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.1 | 2.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 0.6 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 0.1 | 0.5 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.1 | 0.6 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.1 | 0.4 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) |
| 0.1 | 2.2 | GO:0045120 | pronucleus(GO:0045120) |
| 0.1 | 0.3 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.1 | 0.5 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 0.3 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 0.8 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.1 | 0.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 1.1 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 0.7 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 0.4 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.1 | 0.7 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.1 | 0.4 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 1.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 3.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 2.6 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 0.9 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 0.7 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 0.6 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 1.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.3 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.1 | 0.8 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 0.3 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.1 | 0.1 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.1 | 0.5 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.1 | 0.4 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.1 | 1.2 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.2 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.0 | 0.3 | GO:0072588 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
| 0.0 | 0.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 2.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 6.3 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 1.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.6 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 0.2 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 2.5 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.0 | 0.3 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.3 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 0.4 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 12.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.0 | 0.3 | GO:0060091 | kinocilium(GO:0060091) |
| 0.0 | 1.3 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.4 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.0 | 0.2 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.0 | 2.6 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 2.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.7 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 2.2 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.7 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 0.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.3 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 0.4 | GO:0005838 | proteasome regulatory particle(GO:0005838) proteasome accessory complex(GO:0022624) |
| 0.0 | 1.1 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.1 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 1.2 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.2 | GO:0071664 | beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664) |
| 0.0 | 0.4 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.2 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 1.5 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 0.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 1.2 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.6 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.7 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.2 | GO:0042571 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.3 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 1.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 0.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 2.0 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 2.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.3 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.2 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 3.1 | GO:0016604 | nuclear body(GO:0016604) |
| 0.0 | 0.3 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.6 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.4 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.8 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.9 | 2.7 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.7 | 2.1 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.6 | 1.8 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.5 | 1.6 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.4 | 1.3 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.4 | 2.2 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.4 | 2.2 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.4 | 1.2 | GO:0030249 | guanylate cyclase regulator activity(GO:0030249) |
| 0.4 | 1.5 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.4 | 4.0 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.3 | 1.3 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.3 | 2.3 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.3 | 1.3 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.3 | 0.8 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.2 | 0.9 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.2 | 0.6 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.2 | 1.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.2 | 1.1 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.2 | 1.2 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.1 | 1.9 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.1 | 0.4 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.1 | 0.7 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.1 | 2.0 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.1 | 5.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 1.6 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.1 | 0.4 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.1 | 3.0 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 1.5 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 0.8 | GO:0016453 | acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453) |
| 0.1 | 1.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 0.6 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
| 0.1 | 0.4 | GO:0031750 | D3 dopamine receptor binding(GO:0031750) |
| 0.1 | 0.5 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.1 | 2.7 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.1 | 0.4 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.1 | 1.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 0.6 | GO:0017002 | activin-activated receptor activity(GO:0017002) |
| 0.1 | 0.5 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
| 0.1 | 0.3 | GO:0070140 | isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140) |
| 0.1 | 3.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.9 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 0.4 | GO:0036468 | aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468) |
| 0.1 | 0.6 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.1 | 17.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 0.5 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.1 | 1.1 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.0 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 0.6 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.1 | 0.6 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 0.9 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 0.9 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 0.1 | 1.0 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 0.4 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.1 | 0.4 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.1 | 0.8 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
| 0.1 | 1.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 0.3 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 0.4 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 0.2 | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534) |
| 0.1 | 4.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 1.2 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.1 | 0.8 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 1.0 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 0.2 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 0.1 | 0.9 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.1 | 0.2 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.1 | 1.0 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 0.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 2.0 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 0.2 | GO:0004441 | inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) |
| 0.1 | 0.4 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.1 | 0.6 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.1 | 1.6 | GO:0042805 | actinin binding(GO:0042805) |
| 0.1 | 0.6 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 0.5 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 0.3 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.0 | 0.3 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.0 | 2.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.3 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.0 | 1.0 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 0.4 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 1.2 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 1.4 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 0.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.7 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) |
| 0.0 | 1.2 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 4.4 | GO:0035326 | enhancer binding(GO:0035326) |
| 0.0 | 0.7 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 0.8 | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646) |
| 0.0 | 0.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 0.3 | GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624) |
| 0.0 | 2.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.1 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
| 0.0 | 0.2 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.0 | 0.6 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.0 | 0.4 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 2.8 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 2.4 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.9 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 0.4 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.4 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.0 | 0.7 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 0.3 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.1 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.0 | 0.9 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 0.1 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.0 | 0.6 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.1 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.0 | 0.1 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.0 | 0.2 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.0 | 0.4 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.5 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.0 | 0.8 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.3 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.1 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.0 | 0.2 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.5 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 0.1 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.0 | 1.1 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.2 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 9.3 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 1.4 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.5 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 7.0 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 6.1 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.2 | GO:0043028 | cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028) |
| 0.0 | 0.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 6.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 2.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 4.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 2.6 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.0 | 0.8 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 0.6 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 0.3 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.2 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 1.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.5 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.3 | 3.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 4.5 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 1.4 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 3.7 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.1 | 4.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 3.9 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.1 | 1.7 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.9 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.9 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 4.3 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.1 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.1 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.7 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.9 | PID_FAS_PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 0.1 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.1 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 1.3 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 1.4 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.8 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.3 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.2 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.2 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 2.0 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.6 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.0 | 0.4 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.6 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.8 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.8 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 0.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.8 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.4 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.5 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.5 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.3 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.2 | 5.2 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.2 | 1.6 | REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.2 | 3.1 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.2 | 2.7 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 2.2 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 2.2 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 3.3 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.1 | 7.4 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 1.4 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 3.0 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.6 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 0.9 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 2.1 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 0.2 | REACTOME_DOWNSTREAM_TCR_SIGNALING | Genes involved in Downstream TCR signaling |
| 0.1 | 0.6 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 0.8 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.1 | 1.3 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 1.9 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 1.4 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 4.4 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.1 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.2 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.8 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 1.0 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.4 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 2.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.7 | REACTOME_KERATAN_SULFATE_BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 1.2 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.0 | 0.4 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.6 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 2.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.7 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.2 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.8 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.4 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.0 | 1.4 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.4 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.2 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.6 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.2 | REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 1.0 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.4 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.7 | REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.0 | 0.8 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.2 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.1 | REACTOME_REGULATORY_RNA_PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 0.2 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.2 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.6 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.8 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.4 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 2.3 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.1 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.2 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
|
|
|