Motif ID: Gli1

Z-value: 0.748


Transcription factors associated with Gli1:

Gene SymbolEntrez IDGene Name
Gli1 ENSMUSG00000025407.6 Gli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_127341614-0.533.4e-05Click!


Activity profile for motif Gli1.

activity profile for motif Gli1


Sorted Z-values histogram for motif Gli1

Sorted Z-values for motif Gli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 169 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_64090241 4.400 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090265 4.325 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr12_-_81333129 3.721 ENSMUST00000085238.6
ENSMUST00000182208.1
 Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr15_-_95528228 3.528 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr8_+_54954728 3.207 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr6_-_52012476 2.960 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2
chr11_-_119547744 2.945 ENSMUST00000026670.4
 Nptx1
neuronal pentraxin 1
chr15_-_95528702 2.804 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr2_-_54085542 2.693 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr4_-_68954351 2.684 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr15_-_85581809 2.657 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr13_+_118714678 2.614 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr5_+_30588078 2.529 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr18_-_43373248 2.523 ENSMUST00000118043.1
 Dpysl3
dihydropyrimidinase-like 3
chr1_-_56972437 2.516 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr13_-_114458720 2.435 ENSMUST00000022287.5
 Fst
follistatin
chr12_+_44328882 2.316 ENSMUST00000020939.8
ENSMUST00000110748.2
 Nrcam

neuron-glia-CAM-related cell adhesion molecule

chr1_-_133801031 2.258 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr5_+_5573952 2.150 ENSMUST00000101627.2
 Gm8773
predicted gene 8773
chr17_-_24209377 2.076 ENSMUST00000024931.4
 Ntn3
netrin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.6 6.3 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.5 5.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 4.0 GO:0071420 cellular response to histamine(GO:0071420)
0.0 3.9 GO:0002757 immune response-activating signal transduction(GO:0002757)
0.7 3.7 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 3.2 GO:0003407 neural retina development(GO:0003407)
0.6 2.9 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.4 2.9 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.9 2.7 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 2.7 GO:0042711 maternal behavior(GO:0042711)
0.9 2.6 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.9 2.6 GO:2000331 regulation of terminal button organization(GO:2000331)
0.7 2.6 GO:0046967 cytosol to ER transport(GO:0046967)
0.2 2.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 2.5 GO:0051764 actin crosslink formation(GO:0051764)
0.0 2.5 GO:0007050 cell cycle arrest(GO:0007050)
0.8 2.4 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.3 2.4 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.4 2.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 6.2 GO:0031012 extracellular matrix(GO:0031012)
0.0 5.6 GO:0043204 perikaryon(GO:0043204)
0.3 5.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 4.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 3.7 GO:0031594 neuromuscular junction(GO:0031594)
0.1 3.2 GO:0044295 axonal growth cone(GO:0044295)
0.0 3.1 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.7 GO:0060170 ciliary membrane(GO:0060170)
0.4 2.6 GO:0042825 TAP complex(GO:0042825)
0.0 2.5 GO:0031941 filamentous actin(GO:0031941)
0.1 2.3 GO:0097228 sperm principal piece(GO:0097228)
0.1 2.3 GO:0043194 axon initial segment(GO:0043194)
0.0 2.1 GO:0014704 intercalated disc(GO:0014704)
0.0 2.1 GO:0030139 endocytic vesicle(GO:0030139)
0.7 2.0 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 1.9 GO:0097512 cardiac myofibril(GO:0097512)
0.0 1.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.8 GO:0031519 PcG protein complex(GO:0031519)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 6.3 GO:0005080 protein kinase C binding(GO:0005080)
0.1 5.1 GO:0030507 spectrin binding(GO:0030507)
0.2 4.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.4 3.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 3.7 GO:0005262 calcium channel activity(GO:0005262)
0.2 3.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.1 3.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.7 2.7 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.7 2.6 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.7 2.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 2.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 2.5 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.2 2.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 2.4 GO:0048185 activin binding(GO:0048185)
0.5 2.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 2.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 2.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.7 2.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 2.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 5.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.5 PID_BMP_PATHWAY BMP receptor signaling
0.1 3.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 3.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 1.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.2 PID_BCR_5PATHWAY BCR signaling pathway
0.1 1.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 4.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 3.7 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 3.0 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 3.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 2.6 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 2.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.4 2.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 1.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.1 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.1 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.0 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis