Motif ID: Gli3_Zic1

Z-value: 1.060

Transcription factors associated with Gli3_Zic1:

Gene SymbolEntrez IDGene Name
Gli3 ENSMUSG00000021318.9 Gli3
Zic1 ENSMUSG00000032368.8 Zic1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli3mm10_v2_chr13_+_15463837_15463980-0.733.8e-10Click!
Zic1mm10_v2_chr9_-_91365778_91365815-0.384.1e-03Click!


Activity profile for motif Gli3_Zic1.

activity profile for motif Gli3_Zic1


Sorted Z-values histogram for motif Gli3_Zic1

Sorted Z-values for motif Gli3_Zic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli3_Zic1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_70501116 8.150 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr9_+_50752758 7.697 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr6_+_17463749 7.566 ENSMUST00000115443.1
 Met
met proto-oncogene
chr11_-_42000284 6.915 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr17_-_68004075 6.750 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr15_-_95528228 6.690 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr11_-_42000532 6.574 ENSMUST00000070735.3
 Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr7_+_5056856 6.524 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106

chr7_+_5057161 6.207 ENSMUST00000045543.5
 Ccdc106
coiled-coil domain containing 106
chr16_+_91269759 6.049 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr7_+_5056706 5.949 ENSMUST00000144802.1
 Ccdc106
coiled-coil domain containing 106
chr17_-_24209377 5.869 ENSMUST00000024931.4
 Ntn3
netrin 3
chr1_+_195017399 5.767 ENSMUST00000181273.1
 A330023F24Rik
RIKEN cDNA A330023F24 gene
chr4_+_124657646 5.737 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr6_-_101377897 5.644 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr13_-_117025505 5.466 ENSMUST00000022239.6
 Parp8
poly (ADP-ribose) polymerase family, member 8
chr7_+_99268338 5.413 ENSMUST00000107100.2
 Map6
microtubule-associated protein 6
chr11_-_42182163 5.392 ENSMUST00000153147.1
 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr9_-_56418023 5.319 ENSMUST00000061552.8
 C230081A13Rik
RIKEN cDNA C230081A13 gene
chr2_-_155945282 5.249 ENSMUST00000040162.2
 Gdf5
growth differentiation factor 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 24.1 GO:0071420 cellular response to histamine(GO:0071420)
2.6 18.5 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.0 10.9 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.5 8.4 GO:0001553 luteinization(GO:0001553)
1.4 8.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
1.3 7.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 7.7 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
2.4 7.3 GO:1904978 regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
1.7 6.8 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 5.9 GO:0007520 myoblast fusion(GO:0007520)
0.8 5.5 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.2 5.5 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 5.4 GO:0032418 lysosome localization(GO:0032418)
0.9 5.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.5 5.2 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.3 5.2 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
1.7 5.0 GO:0045763 regulation of arginine metabolic process(GO:0000821) negative regulation of cellular amino acid metabolic process(GO:0045763)
1.7 5.0 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
1.7 5.0 GO:2000331 regulation of terminal button organization(GO:2000331)
0.7 5.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 24.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 19.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 11.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 9.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.4 9.2 GO:0032279 asymmetric synapse(GO:0032279)
2.7 8.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
1.3 7.9 GO:0097512 cardiac myofibril(GO:0097512)
0.3 7.3 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.4 7.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 6.7 GO:0043204 perikaryon(GO:0043204)
0.6 6.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 6.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 5.8 GO:0030175 filopodium(GO:0030175)
1.1 5.5 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
1.1 5.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.2 5.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 5.0 GO:0072546 ER membrane protein complex(GO:0072546)
0.2 5.0 GO:0097228 sperm principal piece(GO:0097228)
0.4 4.8 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 4.4 GO:0016604 nuclear body(GO:0016604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 18.5 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
1.1 13.5 GO:0004890 GABA-A receptor activity(GO:0004890)
1.8 10.6 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 9.8 GO:0008201 heparin binding(GO:0008201)
1.2 8.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
1.5 7.3 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.3 7.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 6.8 GO:0008083 growth factor activity(GO:0008083)
0.8 6.5 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.7 6.5 GO:0036122 BMP binding(GO:0036122)
0.1 6.0 GO:0030276 clathrin binding(GO:0030276)
0.2 5.8 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 5.6 GO:0005262 calcium channel activity(GO:0005262)
0.9 5.5 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.1 5.3 GO:0097643 amylin receptor activity(GO:0097643)
0.1 5.2 GO:0042562 hormone binding(GO:0042562)
0.7 5.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.3 5.0 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.3 5.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 5.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.5 21.0 PID_ARF6_PATHWAY Arf6 signaling events
0.2 11.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 7.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 4.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 4.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 4.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 4.4 PID_ARF_3PATHWAY Arf1 pathway
0.0 4.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 2.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.5 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 2.5 PID_TNF_PATHWAY TNF receptor signaling pathway
0.2 2.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 2.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 2.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 1.7 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 24.1 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.4 16.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.8 9.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 8.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 7.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 7.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 6.0 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 5.0 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.7 4.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 4.9 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.3 4.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.4 4.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 4.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 3.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 3.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.2 2.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 2.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 2.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.4 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers