Motif ID: Gli3_Zic1
Z-value: 1.060
Transcription factors associated with Gli3_Zic1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Gli3 | ENSMUSG00000021318.9 | Gli3 |
| Zic1 | ENSMUSG00000032368.8 | Zic1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gli3 | mm10_v2_chr13_+_15463837_15463980 | -0.73 | 3.8e-10 | Click! |
| Zic1 | mm10_v2_chr9_-_91365778_91365815 | -0.38 | 4.1e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 24.1 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 2.6 | 18.5 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 2.4 | 7.3 | GO:1904978 | regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980) |
| 1.7 | 6.8 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 1.7 | 5.0 | GO:0045763 | regulation of arginine metabolic process(GO:0000821) negative regulation of cellular amino acid metabolic process(GO:0045763) |
| 1.7 | 5.0 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) |
| 1.7 | 5.0 | GO:2000331 | regulation of terminal button organization(GO:2000331) |
| 1.6 | 4.8 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 1.5 | 4.5 | GO:0071336 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
| 1.4 | 8.3 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 1.3 | 7.7 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.0 | 10.9 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.9 | 4.7 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.9 | 3.6 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.9 | 5.3 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.9 | 3.5 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.9 | 3.4 | GO:0006558 | L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) |
| 0.9 | 4.3 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.8 | 5.5 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
| 0.8 | 3.0 | GO:0098912 | smooth muscle contraction involved in micturition(GO:0060083) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) |
| 0.7 | 1.4 | GO:0030913 | paranodal junction assembly(GO:0030913) |
| 0.7 | 5.0 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.7 | 2.1 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 0.6 | 5.0 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.6 | 2.5 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.6 | 2.4 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.6 | 4.7 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.6 | 1.7 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.6 | 1.7 | GO:1903903 | striated muscle atrophy(GO:0014891) positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of establishment of T cell polarity(GO:1903903) |
| 0.5 | 3.3 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.5 | 3.2 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.5 | 3.2 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.5 | 1.6 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 0.5 | 8.4 | GO:0001553 | luteinization(GO:0001553) |
| 0.5 | 5.2 | GO:2001054 | negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.5 | 3.1 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
| 0.5 | 0.5 | GO:0007521 | muscle cell fate determination(GO:0007521) |
| 0.5 | 2.6 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.5 | 1.5 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.4 | 2.7 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.4 | 4.9 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.4 | 2.2 | GO:1903587 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) |
| 0.4 | 2.1 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.4 | 1.2 | GO:0061526 | acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) regulation of sulfur amino acid metabolic process(GO:0031335) musculoskeletal movement, spinal reflex action(GO:0050883) acetylcholine secretion(GO:0061526) |
| 0.4 | 1.2 | GO:1905072 | detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072) |
| 0.4 | 4.1 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.4 | 2.4 | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.4 | 1.2 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
| 0.4 | 1.1 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
| 0.3 | 3.6 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.3 | 4.5 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.3 | 2.2 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.3 | 5.2 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.3 | 2.1 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.3 | 1.2 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.3 | 1.4 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.3 | 0.8 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.3 | 1.4 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.3 | 1.4 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.3 | 2.5 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) lipid glycosylation(GO:0030259) |
| 0.3 | 1.1 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 0.3 | 1.1 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.3 | 2.7 | GO:0015838 | proline transport(GO:0015824) amino-acid betaine transport(GO:0015838) |
| 0.3 | 0.8 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.3 | 0.8 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 0.3 | 1.0 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
| 0.3 | 2.0 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 0.3 | 0.8 | GO:0010512 | negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) |
| 0.3 | 1.5 | GO:0048597 | post-embryonic camera-type eye morphogenesis(GO:0048597) |
| 0.2 | 2.0 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.2 | 2.7 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.2 | 0.7 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.2 | 2.8 | GO:0036465 | synaptic vesicle recycling(GO:0036465) |
| 0.2 | 0.9 | GO:0070197 | meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.2 | 1.1 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.2 | 0.7 | GO:0006533 | aspartate catabolic process(GO:0006533) D-amino acid metabolic process(GO:0046416) |
| 0.2 | 1.6 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 2.0 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.2 | 0.4 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.2 | 2.1 | GO:0099612 | protein localization to axon(GO:0099612) |
| 0.2 | 0.8 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.2 | 5.5 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.2 | 1.2 | GO:1902287 | trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287) |
| 0.2 | 1.2 | GO:0000050 | urea cycle(GO:0000050) urea metabolic process(GO:0019627) |
| 0.2 | 1.0 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.2 | 0.6 | GO:0070375 | ERK5 cascade(GO:0070375) |
| 0.2 | 2.8 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
| 0.2 | 2.2 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.2 | 0.9 | GO:0032796 | uropod organization(GO:0032796) |
| 0.2 | 3.0 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.2 | 1.3 | GO:0036506 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 0.2 | 0.6 | GO:0043974 | histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674) |
| 0.2 | 5.9 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.2 | 0.3 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.2 | 0.2 | GO:1900275 | negative regulation of phospholipase C activity(GO:1900275) |
| 0.1 | 0.7 | GO:2000398 | regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398) |
| 0.1 | 0.4 | GO:0021523 | somatic motor neuron differentiation(GO:0021523) |
| 0.1 | 2.0 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.1 | 0.6 | GO:1903028 | regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028) |
| 0.1 | 1.0 | GO:0007182 | common-partner SMAD protein phosphorylation(GO:0007182) positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.1 | 0.7 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.1 | 1.2 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
| 0.1 | 0.5 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.1 | 0.6 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.1 | 0.9 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.1 | 1.4 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.1 | 0.4 | GO:0010360 | negative regulation of anion channel activity(GO:0010360) |
| 0.1 | 2.8 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.1 | 0.5 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 0.1 | 0.8 | GO:0006498 | N-terminal protein lipidation(GO:0006498) |
| 0.1 | 0.1 | GO:0072368 | regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368) |
| 0.1 | 0.8 | GO:0098703 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
| 0.1 | 0.2 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
| 0.1 | 0.8 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.1 | 2.4 | GO:0048305 | immunoglobulin secretion(GO:0048305) |
| 0.1 | 0.3 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.1 | 2.0 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.1 | 1.1 | GO:2001197 | regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197) |
| 0.1 | 0.3 | GO:1903722 | regulation of centriole elongation(GO:1903722) |
| 0.1 | 1.2 | GO:0044539 | long-chain fatty acid import(GO:0044539) |
| 0.1 | 0.7 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.1 | 0.8 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
| 0.1 | 1.3 | GO:1901898 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.1 | 7.7 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 0.1 | 1.8 | GO:0042711 | maternal behavior(GO:0042711) |
| 0.1 | 2.5 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 5.4 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.1 | 0.8 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.1 | 0.8 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 0.3 | GO:1903898 | positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898) |
| 0.1 | 0.4 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.1 | 2.0 | GO:0021692 | cerebellar Purkinje cell layer morphogenesis(GO:0021692) |
| 0.1 | 2.0 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 0.3 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
| 0.1 | 1.3 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.1 | 2.2 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 0.3 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.1 | 0.9 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 4.4 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.1 | 1.7 | GO:0033198 | response to ATP(GO:0033198) |
| 0.1 | 4.2 | GO:0048663 | neuron fate commitment(GO:0048663) |
| 0.1 | 0.6 | GO:0021960 | anterior commissure morphogenesis(GO:0021960) |
| 0.1 | 3.5 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 2.0 | GO:0034243 | regulation of transcription elongation from RNA polymerase II promoter(GO:0034243) |
| 0.1 | 2.1 | GO:0048821 | erythrocyte development(GO:0048821) |
| 0.1 | 0.2 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 0.1 | 1.1 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 0.9 | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation(GO:1904707) |
| 0.1 | 1.0 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.1 | 0.4 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.1 | 0.3 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.1 | 0.9 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.1 | 0.5 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.1 | 0.2 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.1 | 0.2 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.1 | 1.0 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.0 | 1.1 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.3 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.0 | 2.5 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
| 0.0 | 0.6 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.3 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.0 | 1.2 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.7 | GO:0072348 | sulfur compound transport(GO:0072348) |
| 0.0 | 1.8 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
| 0.0 | 2.3 | GO:0045839 | negative regulation of mitotic nuclear division(GO:0045839) |
| 0.0 | 1.0 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
| 0.0 | 3.0 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.0 | 0.2 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
| 0.0 | 0.4 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.0 | 0.5 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 0.3 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 1.9 | GO:0050729 | positive regulation of inflammatory response(GO:0050729) |
| 0.0 | 0.3 | GO:0071557 | somite rostral/caudal axis specification(GO:0032525) histone H3-K27 demethylation(GO:0071557) |
| 0.0 | 0.2 | GO:0099640 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) axo-dendritic protein transport(GO:0099640) |
| 0.0 | 0.5 | GO:0042092 | type 2 immune response(GO:0042092) |
| 0.0 | 1.0 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.6 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.0 | 0.7 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 1.1 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 0.4 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
| 0.0 | 3.2 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 2.0 | GO:0035308 | negative regulation of protein dephosphorylation(GO:0035308) |
| 0.0 | 0.7 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 3.5 | GO:0006457 | protein folding(GO:0006457) |
| 0.0 | 3.4 | GO:0006813 | potassium ion transport(GO:0006813) |
| 0.0 | 0.1 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.0 | 0.8 | GO:0021799 | cerebral cortex radially oriented cell migration(GO:0021799) |
| 0.0 | 0.5 | GO:0070266 | necroptotic process(GO:0070266) |
| 0.0 | 2.9 | GO:0006906 | vesicle fusion(GO:0006906) |
| 0.0 | 2.0 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 0.3 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.9 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 0.5 | GO:0001825 | blastocyst formation(GO:0001825) |
| 0.0 | 0.3 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.0 | 0.4 | GO:0031398 | positive regulation of protein ubiquitination(GO:0031398) |
| 0.0 | 0.5 | GO:0072384 | organelle transport along microtubule(GO:0072384) |
| 0.0 | 0.2 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 0.4 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 8.2 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 1.6 | 24.1 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 1.3 | 7.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.1 | 5.5 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 1.1 | 5.3 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.8 | 4.2 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.7 | 2.1 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.7 | 2.6 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.6 | 6.5 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.5 | 3.0 | GO:0008091 | spectrin(GO:0008091) |
| 0.4 | 9.2 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.4 | 4.8 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.4 | 1.2 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.4 | 7.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.4 | 5.0 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.3 | 19.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.3 | 7.3 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
| 0.3 | 2.0 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.2 | 5.0 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.2 | 9.6 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.2 | 0.9 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.2 | 1.1 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.2 | 3.3 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.2 | 2.0 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.2 | 1.3 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.2 | 0.9 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.2 | 1.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.2 | 2.6 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.2 | 5.1 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 0.6 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.1 | 3.6 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.1 | 3.7 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 0.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 2.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 0.7 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.1 | 2.3 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.1 | 3.7 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 1.6 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.1 | 2.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 0.7 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 0.6 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 0.9 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.1 | 4.3 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 0.5 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 2.2 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 0.3 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 0.3 | GO:0099524 | region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524) |
| 0.1 | 2.5 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.1 | 2.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 0.8 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 0.3 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 6.7 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 5.8 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 0.2 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 0.8 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 4.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 2.0 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 2.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.8 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 0.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 1.0 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 1.2 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.6 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 3.8 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 0.3 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.2 | GO:0033648 | host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648) |
| 0.0 | 0.7 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.4 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 1.5 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 1.6 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 6.1 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.5 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 1.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.6 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.3 | GO:0012506 | vesicle membrane(GO:0012506) |
| 0.0 | 0.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.8 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 0.7 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 1.6 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 0.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.6 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 1.1 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 11.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 0.1 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.0 | 4.4 | GO:0016604 | nuclear body(GO:0016604) |
| 0.0 | 0.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 18.5 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 1.8 | 10.6 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 1.5 | 7.3 | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) |
| 1.4 | 4.3 | GO:0070905 | serine binding(GO:0070905) |
| 1.2 | 4.7 | GO:0004096 | catalase activity(GO:0004096) |
| 1.2 | 8.2 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 1.1 | 4.5 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 1.1 | 13.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 1.1 | 3.3 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 1.1 | 5.3 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.9 | 5.5 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.9 | 3.6 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.8 | 6.5 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.8 | 3.1 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.8 | 2.3 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.7 | 5.1 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.7 | 6.5 | GO:0036122 | BMP binding(GO:0036122) |
| 0.7 | 2.1 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.7 | 4.9 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.6 | 4.7 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.6 | 2.2 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.4 | 4.9 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.4 | 4.8 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.4 | 1.2 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
| 0.4 | 2.0 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.4 | 2.7 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.4 | 3.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 1.1 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) |
| 0.3 | 2.7 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.3 | 7.1 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.3 | 5.0 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.3 | 2.0 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.3 | 1.6 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.3 | 1.2 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.3 | 1.7 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.3 | 0.8 | GO:0001888 | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888) |
| 0.3 | 2.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.3 | 1.4 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.3 | 5.0 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.3 | 1.1 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.3 | 2.2 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.3 | 0.8 | GO:0016880 | acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.3 | 2.0 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.2 | 3.9 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.2 | 0.9 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.2 | 1.5 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.2 | 5.8 | GO:0008376 | acetylgalactosaminyltransferase activity(GO:0008376) |
| 0.2 | 0.9 | GO:0004724 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) |
| 0.2 | 5.0 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.2 | 0.5 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.2 | 0.5 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.2 | 4.1 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 0.7 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.1 | 4.8 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 1.3 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 0.4 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 0.4 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 0.1 | 1.5 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 1.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 1.9 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.1 | 6.0 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 2.8 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 1.2 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 0.6 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.1 | 6.8 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.1 | 1.4 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 1.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 1.2 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) |
| 0.1 | 0.9 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 1.3 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 0.6 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.1 | 2.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 0.8 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.1 | 4.9 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 9.8 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 0.7 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.1 | 3.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 2.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 1.7 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 0.1 | 5.2 | GO:0042562 | hormone binding(GO:0042562) |
| 0.1 | 0.3 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.1 | 1.0 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 0.7 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.1 | 0.5 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.1 | 0.9 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 1.1 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.1 | 5.6 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 0.6 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
| 0.1 | 0.3 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 1.6 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.1 | 0.4 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 0.6 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.1 | 0.9 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.1 | 0.3 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
| 0.1 | 4.1 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 0.4 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 3.4 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 0.7 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.1 | 0.7 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 2.5 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.7 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.0 | 2.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.5 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 3.3 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.4 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.0 | 2.4 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 1.6 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 0.3 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.0 | 0.3 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 0.2 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.0 | 0.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.8 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 4.2 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 1.2 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 1.7 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 3.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.5 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.3 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.0 | 0.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 2.1 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.2 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.8 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.3 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.0 | 2.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 2.1 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.1 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 0.0 | 0.8 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.0 | 0.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.1 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.6 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.4 | GO:0043236 | laminin binding(GO:0043236) |
| 0.0 | 0.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 3.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.1 | GO:0015501 | sodium:amino acid symporter activity(GO:0005283) glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.2 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 21.0 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.2 | 7.2 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 11.7 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.2 | 4.7 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.2 | 2.3 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.2 | 4.4 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.2 | 4.5 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.1 | 4.7 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 1.5 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 22.1 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.1 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 2.5 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 1.7 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
| 0.1 | 0.8 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 1.4 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 1.1 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 1.8 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 2.8 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.0 | 1.2 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 2.7 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.5 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.0 | 4.1 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.3 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.7 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 2.0 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 1.1 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.8 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.3 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.0 | 0.7 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 1.0 | PID_NFAT_3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.0 | 1.0 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.6 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.2 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.7 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.2 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.9 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.1 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 24.1 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.8 | 9.8 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.7 | 4.9 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.4 | 16.3 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.4 | 4.9 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.4 | 4.5 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.3 | 4.8 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.2 | 2.5 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.2 | 8.9 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 1.3 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.2 | 7.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.2 | 6.0 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.2 | 2.4 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 3.2 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 1.5 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.7 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 4.5 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 7.2 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.6 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 1.5 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 2.4 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 1.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 0.7 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 1.2 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 0.7 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 5.0 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 0.6 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 1.2 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 0.9 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 1.1 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 3.7 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 0.5 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 2.0 | REACTOME_INWARDLY_RECTIFYING_K_CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 2.0 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.1 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 0.6 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.8 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.3 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.4 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.3 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 2.5 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.6 | REACTOME_KERATAN_SULFATE_BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.9 | REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 1.0 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 1.2 | REACTOME_REGULATION_OF_INSULIN_SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.0 | 0.3 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.6 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.7 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
|
|
|