Motif ID: Glis2

Z-value: 1.011


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_45947350.265.3e-02Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 174 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 16.193 ENSMUST00000005019.5
Crabp2
cellular retinoic acid binding protein II
chr6_-_48840988 9.160 ENSMUST00000164733.1
Tmem176b
transmembrane protein 176B
chr4_+_109978004 7.461 ENSMUST00000061187.3
Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr17_-_56830916 6.854 ENSMUST00000002444.7
ENSMUST00000086801.5
Rfx2

regulatory factor X, 2 (influences HLA class II expression)

chr6_-_48841098 6.640 ENSMUST00000101429.4
Tmem176b
transmembrane protein 176B
chr19_+_7268296 6.557 ENSMUST00000066646.4
Rcor2
REST corepressor 2
chr6_-_48841373 6.524 ENSMUST00000166247.1
Tmem176b
transmembrane protein 176B
chr11_+_101468164 6.474 ENSMUST00000001347.6
Rnd2
Rho family GTPase 2
chr6_+_48841476 6.262 ENSMUST00000101426.4
Tmem176a
transmembrane protein 176A
chr4_-_58499398 6.151 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr6_+_48841633 6.109 ENSMUST00000168406.1
Tmem176a
transmembrane protein 176A
chr2_-_54085542 5.945 ENSMUST00000100089.2
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr2_-_75704535 5.780 ENSMUST00000102672.4
Nfe2l2
nuclear factor, erythroid derived 2, like 2
chr2_+_105668888 5.116 ENSMUST00000111086.4
ENSMUST00000111087.3
Pax6

paired box gene 6

chr11_+_72042455 4.963 ENSMUST00000021164.3
Fam64a
family with sequence similarity 64, member A
chr6_+_120666388 4.880 ENSMUST00000112686.1
Cecr2
cat eye syndrome chromosome region, candidate 2
chr13_-_29984219 4.849 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr7_-_103843154 4.767 ENSMUST00000063957.4
Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr14_+_55854115 4.462 ENSMUST00000168479.1
Nynrin
NYN domain and retroviral integrase containing
chr5_+_136083916 4.305 ENSMUST00000042135.7
Rasa4
RAS p21 protein activator 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.0 34.7 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.5 22.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.8 9.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.2 8.5 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.7 7.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.5 6.9 GO:0001675 acrosome assembly(GO:0001675)
1.1 6.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
1.5 6.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 5.9 GO:0007050 cell cycle arrest(GO:0007050)
1.4 5.8 GO:1902037 proteasomal ubiquitin-independent protein catabolic process(GO:0010499) positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.6 5.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.6 5.8 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
1.3 5.0 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.5 4.9 GO:0001842 neural fold formation(GO:0001842)
1.6 4.8 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
1.0 4.8 GO:0015671 oxygen transport(GO:0015671)
0.6 4.5 GO:0015074 DNA integration(GO:0015074)
0.8 3.9 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 3.7 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 3.7 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 GO:0005667 transcription factor complex(GO:0005667)
0.6 8.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 7.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 7.0 GO:0005882 intermediate filament(GO:0005882)
0.0 6.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 6.4 GO:0005769 early endosome(GO:0005769)
0.1 6.2 GO:0043198 dendritic shaft(GO:0043198)
0.4 5.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.7 5.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 5.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.1 GO:0016607 nuclear speck(GO:0016607)
1.2 4.9 GO:0090537 CERF complex(GO:0090537)
0.6 4.8 GO:0005833 hemoglobin complex(GO:0005833)
0.0 4.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 4.1 GO:0016235 aggresome(GO:0016235)
0.0 3.9 GO:0005925 focal adhesion(GO:0005925)
0.1 3.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
1.1 3.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 3.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.9 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 27.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
2.7 16.2 GO:0019841 retinol binding(GO:0019841)
0.6 9.1 GO:0003680 AT DNA binding(GO:0003680)
0.8 7.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.9 6.2 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 6.2 GO:0047485 protein N-terminus binding(GO:0047485)
1.0 5.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 5.8 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 5.8 GO:0001047 core promoter binding(GO:0001047)
0.8 5.7 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.2 5.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
1.6 4.8 GO:0010698 acetyltransferase activator activity(GO:0010698)
1.2 4.8 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 3.9 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 3.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.6 3.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.1 3.4 GO:0070052 collagen V binding(GO:0070052)
0.0 3.3 GO:0004540 ribonuclease activity(GO:0004540)
1.1 3.2 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.7 2.9 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 7.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 6.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 6.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 6.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 4.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 3.4 PID_CDC42_PATHWAY CDC42 signaling events
0.1 2.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.7 ST_ADRENERGIC Adrenergic Pathway
0.0 2.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.1 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.9 PID_FGF_PATHWAY FGF signaling pathway
0.1 1.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.8 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 1.7 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 9.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 7.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.6 6.6 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 6.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 5.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.5 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 4.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.5 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 3.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 2.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 2.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.6 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.1 2.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 2.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 1.9 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.7 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins