Motif ID: Glis3

Z-value: 0.570


Transcription factors associated with Glis3:

Gene SymbolEntrez IDGene Name
Glis3 ENSMUSG00000052942.7 Glis3
Glis3 ENSMUSG00000091294.1 Glis3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis3mm10_v2_chr19_-_28680077_286801220.384.5e-03Click!


Activity profile for motif Glis3.

activity profile for motif Glis3


Sorted Z-values histogram for motif Glis3

Sorted Z-values for motif Glis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 126 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 2.877 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr6_+_17463749 2.826 ENSMUST00000115443.1
Met
met proto-oncogene
chr8_+_70501116 2.653 ENSMUST00000127983.1
Crlf1
cytokine receptor-like factor 1
chr4_+_144893077 2.505 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_17463927 2.284 ENSMUST00000115442.1
Met
met proto-oncogene
chr4_+_144893127 2.249 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_17463826 2.129 ENSMUST00000140070.1
Met
met proto-oncogene
chr7_-_142657466 1.960 ENSMUST00000097936.2
ENSMUST00000000033.5
Igf2

insulin-like growth factor 2

chr11_-_102296618 1.669 ENSMUST00000107132.2
ENSMUST00000073234.2
Atxn7l3

ataxin 7-like 3

chr13_+_38345716 1.107 ENSMUST00000171970.1
Bmp6
bone morphogenetic protein 6
chr10_-_68278713 1.018 ENSMUST00000020106.7
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr3_+_52268337 0.974 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr2_+_32646586 0.808 ENSMUST00000009705.7
ENSMUST00000167841.1
Eng

endoglin

chr11_+_5861886 0.763 ENSMUST00000102923.3
Aebp1
AE binding protein 1
chrM_+_9452 0.744 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chrX_-_136868537 0.722 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr1_-_64121389 0.658 ENSMUST00000055001.3
Klf7
Kruppel-like factor 7 (ubiquitous)
chr1_-_64121456 0.639 ENSMUST00000142009.1
ENSMUST00000114086.1
Klf7

Kruppel-like factor 7 (ubiquitous)

chr13_+_119690462 0.628 ENSMUST00000179869.1
Hmgcs1
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
chrM_+_8600 0.567 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.6 GO:0042572 retinol metabolic process(GO:0042572)
1.0 7.2 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 2.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 2.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 1.7 GO:0016578 histone deubiquitination(GO:0016578)
0.4 1.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.2 1.1 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.1 1.0 GO:0060613 fat pad development(GO:0060613)
0.1 1.0 GO:0071455 response to hyperoxia(GO:0055093) cellular response to hyperoxia(GO:0071455)
0.3 0.8 GO:1905072 detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
0.0 0.7 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.7 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.7 GO:0033233 regulation of protein sumoylation(GO:0033233)
0.0 0.6 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.2 0.5 GO:0070172 oculomotor nerve development(GO:0021557) positive regulation of tooth mineralization(GO:0070172)
0.1 0.4 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.1 0.4 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 0.4 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.4 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 0.4 GO:0021993 initiation of neural tube closure(GO:0021993)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.5 GO:0009925 basal plasma membrane(GO:0009925)
0.9 2.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.7 GO:0000124 SAGA complex(GO:0000124)
0.0 1.1 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.7 GO:0071203 WASH complex(GO:0071203)
0.0 0.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.4 GO:0033503 HULC complex(GO:0033503)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.1 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 7.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.8 7.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4 2.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 2.0 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.1 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 0.8 GO:0005534 galactose binding(GO:0005534)
0.1 0.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.4 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.4 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.1 0.4 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.4 GO:2001069 glycogen binding(GO:2001069)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 7.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.0 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.1 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.4 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 1.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation