Motif ID: Gmeb1
Z-value: 0.570
Transcription factors associated with Gmeb1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Gmeb1 | ENSMUSG00000028901.7 | Gmeb1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gmeb1 | mm10_v2_chr4_-_132261596_132261622 | 0.49 | 1.3e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 8.9 | GO:0051316 | attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316) |
| 1.1 | 8.0 | GO:0098535 | positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535) |
| 0.8 | 2.3 | GO:0046544 | regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544) |
| 0.7 | 5.2 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.5 | 1.4 | GO:0034241 | positive regulation of macrophage fusion(GO:0034241) |
| 0.5 | 4.6 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
| 0.5 | 2.7 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.3 | 1.4 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.2 | 0.7 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
| 0.2 | 0.6 | GO:0000715 | nucleotide-excision repair, DNA damage recognition(GO:0000715) |
| 0.2 | 2.1 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.2 | 0.5 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) |
| 0.1 | 1.2 | GO:0061084 | negative regulation of protein refolding(GO:0061084) |
| 0.1 | 2.3 | GO:0042407 | cristae formation(GO:0042407) |
| 0.1 | 3.0 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.1 | 0.3 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364) |
| 0.1 | 0.4 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.1 | 0.2 | GO:0006592 | ornithine biosynthetic process(GO:0006592) |
| 0.0 | 0.6 | GO:0043619 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619) |
| 0.0 | 3.0 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.0 | 0.6 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 0.2 | GO:0072717 | cellular response to actinomycin D(GO:0072717) |
| 0.0 | 0.5 | GO:0061525 | hindgut development(GO:0061525) left/right axis specification(GO:0070986) |
| 0.0 | 1.5 | GO:0030835 | negative regulation of actin filament depolymerization(GO:0030835) |
| 0.0 | 0.3 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.0 | 0.2 | GO:0060972 | left/right pattern formation(GO:0060972) |
| 0.0 | 0.4 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.0 | 0.3 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 0.8 | GO:0045216 | cell-cell junction organization(GO:0045216) |
| 0.0 | 0.4 | GO:0006515 | misfolded or incompletely synthesized protein catabolic process(GO:0006515) |
| 0.0 | 1.2 | GO:0019395 | fatty acid oxidation(GO:0019395) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 8.9 | GO:0000939 | nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939) |
| 1.3 | 8.0 | GO:0098536 | deuterosome(GO:0098536) |
| 0.3 | 2.3 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.1 | 0.6 | GO:0071942 | XPC complex(GO:0071942) |
| 0.1 | 1.4 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.1 | 1.4 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 1.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 1.2 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 4.1 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 0.9 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.1 | 0.7 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 0.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 5.0 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 0.5 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 1.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.5 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.6 | GO:0008309 | double-stranded DNA exodeoxyribonuclease activity(GO:0008309) |
| 0.4 | 1.2 | GO:0032564 | dATP binding(GO:0032564) |
| 0.4 | 1.5 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.4 | 3.0 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.2 | 0.6 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.2 | 5.6 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.2 | 2.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.6 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 0.2 | GO:0017084 | glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202) |
| 0.1 | 2.3 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.8 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 1.4 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.1 | 0.3 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.0 | 1.4 | GO:0043236 | laminin binding(GO:0043236) |
| 0.0 | 0.2 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.0 | 4.1 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.6 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 1.2 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.0 | 0.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 1.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.4 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 6.0 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 0.6 | GO:0031593 | polyubiquitin binding(GO:0031593) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.1 | 2.3 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.0 | 3.0 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.6 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.5 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.2 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.3 | 2.8 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 2.3 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 1.4 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 6.6 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 7.7 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.8 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.5 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.6 | REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 1.6 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
