Motif ID: Gmeb1

Z-value: 0.570


Transcription factors associated with Gmeb1:

Gene SymbolEntrez IDGene Name
Gmeb1 ENSMUSG00000028901.7 Gmeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb1mm10_v2_chr4_-_132261596_1322616220.491.3e-04Click!


Activity profile for motif Gmeb1.

activity profile for motif Gmeb1


Sorted Z-values histogram for motif Gmeb1

Sorted Z-values for motif Gmeb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 66 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_113531675 5.231 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr15_+_99074968 4.939 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr2_-_157007039 4.640 ENSMUST00000103129.2
ENSMUST00000103130.1
 Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr1_+_175880775 4.585 ENSMUST00000039725.6
 Exo1
exonuclease 1
chr2_-_157007015 4.210 ENSMUST00000146413.1
 Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr3_+_40800054 4.154 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr8_-_94918012 4.101 ENSMUST00000077955.5
 Ccdc102a
coiled-coil domain containing 102A
chr3_+_40800013 3.831 ENSMUST00000026858.5
ENSMUST00000170825.1
 Plk4

polo-like kinase 4

chr3_+_127553462 3.368 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr7_-_19310035 2.954 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr11_-_40733373 2.827 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr19_+_43612299 2.717 ENSMUST00000057178.9
 Nkx2-3
NK2 homeobox 3
chr11_-_100822525 2.286 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chrX_+_112311334 2.260 ENSMUST00000026599.3
ENSMUST00000113415.1
 Apool

apolipoprotein O-like

chr15_-_58135047 1.653 ENSMUST00000038194.3
 Atad2
ATPase family, AAA domain containing 2
chr3_+_138143429 1.591 ENSMUST00000040321.6
 Trmt10a
tRNA methyltransferase 10A
chr2_+_75659253 1.535 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
 Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr17_+_84511832 1.475 ENSMUST00000047206.5
 Plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr3_+_138143483 1.409 ENSMUST00000162864.1
 Trmt10a
tRNA methyltransferase 10A
chr3_-_138143352 1.353 ENSMUST00000098580.2
 Mttp
microsomal triglyceride transfer protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 8.9 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
1.1 8.0 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.7 5.2 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.5 4.6 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 3.0 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 3.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.5 2.7 GO:0002317 plasma cell differentiation(GO:0002317)
0.8 2.3 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.1 2.3 GO:0042407 cristae formation(GO:0042407)
0.2 2.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 1.5 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.5 1.4 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.3 1.4 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 1.2 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.0 1.2 GO:0019395 fatty acid oxidation(GO:0019395)
0.0 0.8 GO:0045216 cell-cell junction organization(GO:0045216)
0.2 0.7 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.2 0.6 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.6 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.6 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 8.9 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
1.3 8.0 GO:0098536 deuterosome(GO:0098536)
0.0 5.0 GO:0000793 condensed chromosome(GO:0000793)
0.1 4.1 GO:0016459 myosin complex(GO:0016459)
0.3 2.3 GO:0061617 MICOS complex(GO:0061617)
0.1 1.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 1.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.2 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.9 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.6 GO:0071942 XPC complex(GO:0071942)
0.0 0.5 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.2 5.6 GO:0070182 DNA polymerase binding(GO:0070182)
1.1 4.6 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0 4.1 GO:0003774 motor activity(GO:0003774)
0.4 3.0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.2 2.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.4 1.5 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 1.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.4 GO:0043236 laminin binding(GO:0043236)
0.0 1.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 1.2 GO:0032564 dATP binding(GO:0032564)
0.0 1.2 GO:0004497 monooxygenase activity(GO:0004497)
0.1 0.8 GO:0001618 virus receptor activity(GO:0001618)
0.2 0.6 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 PID_BARD1_PATHWAY BARD1 signaling events
0.0 3.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 6.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.5 5.2 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.3 2.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 2.3 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.6 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation