Motif ID: Grhl1

Z-value: 0.372


Transcription factors associated with Grhl1:

Gene SymbolEntrez IDGene Name
Grhl1 ENSMUSG00000020656.9 Grhl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Grhl1mm10_v2_chr12_+_24572276_245723080.066.6e-01Click!


Activity profile for motif Grhl1.

activity profile for motif Grhl1


Sorted Z-values histogram for motif Grhl1

Sorted Z-values for motif Grhl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Grhl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 52 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_105399286 1.863 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr17_+_87635974 1.770 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr2_-_151973387 1.766 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chrX_+_100730178 1.685 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr16_-_26989974 1.547 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr2_+_172550761 1.404 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr18_+_56432116 1.096 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr8_-_71381907 0.943 ENSMUST00000002466.8
 Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr4_+_141242850 0.796 ENSMUST00000138096.1
ENSMUST00000006618.2
ENSMUST00000125392.1
 Arhgef19


Rho guanine nucleotide exchange factor (GEF) 19


chr14_+_79481164 0.785 ENSMUST00000040131.5
 Elf1
E74-like factor 1
chr6_+_128438757 0.746 ENSMUST00000144745.1
 Gm10069
predicted gene 10069
chrX_-_38456407 0.649 ENSMUST00000074913.5
ENSMUST00000016678.7
ENSMUST00000061755.8
 Lamp2


lysosomal-associated membrane protein 2


chr4_+_109676568 0.611 ENSMUST00000102724.4
 Faf1
Fas-associated factor 1
chr7_+_101321703 0.601 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chr14_-_79481268 0.549 ENSMUST00000022601.5
 Wbp4
WW domain binding protein 4
chr19_-_18631754 0.542 ENSMUST00000025631.6
 Ostf1
osteoclast stimulating factor 1
chr10_+_128747850 0.541 ENSMUST00000163377.2
 Wibg
within bgcn homolog (Drosophila)
chr14_-_57133268 0.531 ENSMUST00000160703.1
 Gjb6
gap junction protein, beta 6
chr17_-_56005566 0.517 ENSMUST00000043785.6
 Stap2
signal transducing adaptor family member 2
chr14_+_75136326 0.491 ENSMUST00000145303.1
 Lcp1
lymphocyte cytosolic protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.8 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.2 1.7 GO:0090527 actin filament reorganization(GO:0090527)
0.0 1.5 GO:0006270 DNA replication initiation(GO:0006270)
0.5 1.4 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 0.9 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 0.8 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 0.6 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.1 0.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.6 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.5 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.5 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.4 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 0.4 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.1 0.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.4 GO:0001706 endoderm formation(GO:0001706)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.3 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.7 GO:0005884 actin filament(GO:0005884)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 0.6 GO:0031088 platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.1 0.2 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)

Gene overrepresentation in molecular_function category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 1.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 1.7 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.2 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis