Motif ID: Gsc2_Dmbx1

Z-value: 0.636

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.359.6e-03Click!


Activity profile for motif Gsc2_Dmbx1.

activity profile for motif Gsc2_Dmbx1


Sorted Z-values histogram for motif Gsc2_Dmbx1

Sorted Z-values for motif Gsc2_Dmbx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 86 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_137766474 9.793 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr14_-_118052235 9.413 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr4_+_154960915 6.782 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr5_+_3344194 5.775 ENSMUST00000042410.4
 Cdk6
cyclin-dependent kinase 6
chr5_+_3343893 5.673 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr2_+_91259822 5.382 ENSMUST00000138470.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr11_+_78322965 4.509 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr13_-_116309639 3.114 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr14_-_31640878 3.020 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
 Hacl1


2-hydroxyacyl-CoA lyase 1


chr17_+_35861318 2.771 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr11_-_68973840 2.756 ENSMUST00000038644.4
 Rangrf
RAN guanine nucleotide release factor
chr4_-_141053660 2.717 ENSMUST00000040222.7
 Crocc
ciliary rootlet coiled-coil, rootletin
chr11_-_52282564 2.395 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr17_+_35861343 2.246 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr2_+_164562579 2.145 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr17_-_58991343 2.108 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr13_+_3361029 2.044 ENSMUST00000179981.1
 Gm16505
predicted gene 16505
chr1_+_44551483 1.731 ENSMUST00000074525.3
 Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr5_+_77265454 1.674 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor
chr2_-_51972990 1.412 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.4 GO:0044838 cell quiescence(GO:0044838)
0.2 9.8 GO:0046677 response to antibiotic(GO:0046677)
1.6 9.4 GO:0006570 tyrosine metabolic process(GO:0006570)
1.7 6.8 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.2 5.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.5 4.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.9 3.6 GO:0032053 ciliary basal body organization(GO:0032053)
0.1 3.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.0 3.1 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.6 3.0 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.5 2.8 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.0 2.7 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 2.6 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.8 2.5 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.3 2.4 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 2.1 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.4 1.7 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 1.3 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.4 1.2 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.1 1.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.6 9.8 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.3 9.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 5.0 GO:0005652 nuclear lamina(GO:0005652)
0.2 3.6 GO:0035253 ciliary rootlet(GO:0035253)
0.1 3.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.8 GO:0014704 intercalated disc(GO:0014704)
0.0 2.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.4 1.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.0 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 11.4 GO:0098770 FBXO family protein binding(GO:0098770)
2.4 9.8 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.7 9.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 7.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 5.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.8 4.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 3.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 3.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332)
0.1 3.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 3.0 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 3.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 2.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.4 2.1 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 1.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 1.5 GO:0019894 kinesin binding(GO:0019894)
0.2 1.4 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 1.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 1.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 6.8 PID_CDC42_PATHWAY CDC42 signaling events
0.0 3.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.6 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.6 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.2 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 7.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 4.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 3.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 3.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 3.0 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 2.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins