Motif ID: Gsx2_Hoxd3_Vax1

Z-value: 0.630

Transcription factors associated with Gsx2_Hoxd3_Vax1:

Gene SymbolEntrez IDGene Name
Gsx2 ENSMUSG00000035946.6 Gsx2
Hoxd3 ENSMUSG00000079277.3 Hoxd3
Vax1 ENSMUSG00000006270.6 Vax1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx2mm10_v2_chr5_+_75075464_750756010.731.9e-10Click!
Vax1mm10_v2_chr19_-_59170978_591709780.696.1e-09Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_8710734 11.488 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 10.312 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_14621805 4.871 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr8_+_94152607 4.859 ENSMUST00000034211.8
Mt3
metallothionein 3
chr4_-_14621494 3.103 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 3.003 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr15_+_25773985 2.991 ENSMUST00000125667.1
Myo10
myosin X
chr3_+_66219909 2.937 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr2_+_91457501 2.704 ENSMUST00000028689.3
Lrp4
low density lipoprotein receptor-related protein 4
chr9_-_90255927 2.577 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr2_+_116067213 2.561 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr18_+_56432116 2.248 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr2_+_109917639 2.082 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr18_+_57142782 1.858 ENSMUST00000139892.1
Megf10
multiple EGF-like-domains 10
chr15_+_98571004 1.743 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr3_+_159839729 1.601 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr14_-_48662740 1.382 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr9_+_119063429 1.354 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill


villin-like


chr6_-_34317442 1.323 ENSMUST00000154655.1
ENSMUST00000102980.4
Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr2_+_20737306 1.240 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr2_-_116067391 1.183 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr2_-_168767029 1.183 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr2_+_91257323 1.104 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr2_-_168767136 1.065 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr10_-_8886033 1.049 ENSMUST00000015449.5
Sash1
SAM and SH3 domain containing 1
chr15_-_37459327 1.046 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr13_-_102906046 0.915 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr2_+_71389239 0.914 ENSMUST00000028408.2
Hat1
histone aminotransferase 1
chr3_-_116253467 0.892 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr12_+_38780284 0.891 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr4_+_8690399 0.850 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr3_+_103739366 0.846 ENSMUST00000106852.1
Gm10964
predicted gene 10964
chrX_+_9885622 0.831 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5

synaptotagmin-like 5

chr19_+_55895508 0.800 ENSMUST00000111646.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr14_+_26259109 0.794 ENSMUST00000174494.1
Duxbl3
double homeobox B-like 3
chr13_-_102905740 0.771 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr17_-_70853482 0.770 ENSMUST00000118283.1
Tgif1
TGFB-induced factor homeobox 1
chr13_+_51408618 0.765 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chr15_+_39006272 0.724 ENSMUST00000179165.1
ENSMUST00000022906.7
Fzd6

frizzled homolog 6 (Drosophila)

chr3_-_59220150 0.699 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr12_+_38781093 0.683 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr11_+_59306920 0.654 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr11_-_109611417 0.614 ENSMUST00000103060.3
ENSMUST00000047186.3
ENSMUST00000106689.1
Wipi1


WD repeat domain, phosphoinositide interacting 1


chr1_-_152625212 0.609 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr5_+_66968559 0.606 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr2_+_106693185 0.604 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr3_+_53488677 0.583 ENSMUST00000029307.3
Stoml3
stomatin (Epb7.2)-like 3
chr14_+_26119811 0.568 ENSMUST00000173617.1
Duxbl2
doubl homeobox B-like 2
chr14_+_79515618 0.544 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr12_-_55014329 0.528 ENSMUST00000172875.1
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr12_+_38780817 0.525 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr6_+_8948608 0.518 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr12_-_79296266 0.515 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr8_-_106573461 0.510 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr14_+_25980039 0.472 ENSMUST00000173155.1
Duxbl1
double homeobox B-like 1
chr1_+_161070767 0.471 ENSMUST00000111618.1
ENSMUST00000111620.3
ENSMUST00000028035.7
Cenpl


centromere protein L


chr10_-_83648631 0.461 ENSMUST00000146876.2
ENSMUST00000176294.1
Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr2_-_91649785 0.460 ENSMUST00000111333.1
Zfp408
zinc finger protein 408
chr9_-_39603635 0.449 ENSMUST00000119722.1
AW551984
expressed sequence AW551984
chrX_+_169685191 0.447 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chrX_-_101086020 0.432 ENSMUST00000113710.1
Slc7a3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
chr2_-_91649751 0.426 ENSMUST00000099714.3
Zfp408
zinc finger protein 408
chr5_-_63968867 0.420 ENSMUST00000154169.1
Rell1
RELT-like 1
chr6_-_54566484 0.419 ENSMUST00000019268.4
Scrn1
secernin 1
chr7_+_101896340 0.401 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr2_-_29787622 0.396 ENSMUST00000177467.1
ENSMUST00000113807.3
Trub2

TruB pseudouridine (psi) synthase homolog 2 (E. coli)

chr11_+_60537978 0.374 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr9_+_94669876 0.369 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr14_-_64455903 0.368 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr5_+_48242549 0.358 ENSMUST00000172493.1
Slit2
slit homolog 2 (Drosophila)
chr4_+_154964117 0.351 ENSMUST00000030931.4
ENSMUST00000070953.4
Pank4

pantothenate kinase 4

chr8_+_36489191 0.348 ENSMUST00000171777.1
6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr9_+_121950988 0.326 ENSMUST00000043011.7
Fam198a
family with sequence similarity 198, member A
chrX_+_107255878 0.317 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174


G protein-coupled receptor 174


chr5_+_66968416 0.307 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr13_-_53473074 0.306 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr14_+_47298260 0.302 ENSMUST00000166743.1
Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chrM_-_14060 0.299 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr2_-_120154600 0.257 ENSMUST00000028755.7
Ehd4
EH-domain containing 4
chr5_-_149051300 0.235 ENSMUST00000110505.1
Hmgb1
high mobility group box 1
chr12_+_111814170 0.234 ENSMUST00000021714.7
Zfyve21
zinc finger, FYVE domain containing 21
chr4_-_42661893 0.230 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chrX_+_106920618 0.224 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr4_+_105789869 0.214 ENSMUST00000184254.1
Gm12728
predicted gene 12728
chr19_-_32196393 0.205 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr18_+_33464163 0.201 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr2_+_19371636 0.200 ENSMUST00000023856.8
Msrb2
methionine sulfoxide reductase B2
chr5_+_136987019 0.190 ENSMUST00000004968.4
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr7_+_19368498 0.173 ENSMUST00000132655.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr8_-_112011266 0.173 ENSMUST00000164470.1
ENSMUST00000093120.5
Kars

lysyl-tRNA synthetase

chr10_-_33995054 0.167 ENSMUST00000164429.1
Gm17567
predicted gene, 17567
chr2_-_164171113 0.159 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr11_+_114851507 0.154 ENSMUST00000177952.1
Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr14_+_69347587 0.153 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr4_-_117682233 0.151 ENSMUST00000102687.3
Dmap1
DNA methyltransferase 1-associated protein 1
chrX_-_160138375 0.146 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr2_-_164389095 0.145 ENSMUST00000167427.1
Slpi
secretory leukocyte peptidase inhibitor
chr8_-_112011320 0.145 ENSMUST00000034426.6
Kars
lysyl-tRNA synthetase
chr3_+_19187321 0.139 ENSMUST00000130806.1
ENSMUST00000117529.1
ENSMUST00000119865.1
Mtfr1


mitochondrial fission regulator 1


chr12_-_98577940 0.137 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr4_+_103143052 0.133 ENSMUST00000106855.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr1_-_161070613 0.126 ENSMUST00000035430.3
Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
chr12_+_112760652 0.114 ENSMUST00000063888.3
Pld4
phospholipase D family, member 4
chr6_+_47920476 0.106 ENSMUST00000009411.8
Zfp212
Zinc finger protein 212
chr12_+_102128718 0.105 ENSMUST00000159329.1
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr9_-_13818665 0.086 ENSMUST00000150893.1
ENSMUST00000124883.1
Cep57

centrosomal protein 57

chr10_-_76110956 0.084 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr5_-_3647806 0.063 ENSMUST00000119783.1
ENSMUST00000007559.8
Gatad1

GATA zinc finger domain containing 1

chr2_+_110597298 0.057 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr16_-_89818338 0.055 ENSMUST00000164263.2
Tiam1
T cell lymphoma invasion and metastasis 1
chr3_+_88297147 0.052 ENSMUST00000164166.1
ENSMUST00000168062.1
Cct3

chaperonin containing Tcp1, subunit 3 (gamma)

chr5_-_100416115 0.051 ENSMUST00000182886.1
ENSMUST00000094578.4
Sec31a

Sec31 homolog A (S. cerevisiae)

chr16_-_50330987 0.050 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr7_+_101896817 0.042 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chrX_-_157415286 0.040 ENSMUST00000079945.4
ENSMUST00000138396.1
Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chr1_-_163725123 0.039 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr12_-_80643799 0.038 ENSMUST00000166931.1
Erh
enhancer of rudimentary homolog (Drosophila)
chr2_+_120476911 0.037 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
Capn3



calpain 3



chr4_-_129227883 0.034 ENSMUST00000106051.1
C77080
expressed sequence C77080
chr12_+_80644212 0.033 ENSMUST00000085245.5
Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr14_+_48446128 0.029 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr1_+_93421682 0.026 ENSMUST00000096427.4
Gm17415
predicted gene, 17415
chr3_+_88297115 0.025 ENSMUST00000001452.7
Cct3
chaperonin containing Tcp1, subunit 3 (gamma)
chr13_-_97747373 0.024 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr14_-_52104015 0.022 ENSMUST00000111610.4
ENSMUST00000164655.1
Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr1_-_172027269 0.013 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr5_-_138187177 0.013 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr14_-_104522615 0.013 ENSMUST00000022716.2
Rnf219
ring finger protein 219
chr12_-_87775755 0.011 ENSMUST00000164517.2
Gm21319
predicted gene, 21319
chr7_-_4778141 0.002 ENSMUST00000094892.5
Il11
interleukin 11
chr5_-_137072254 0.000 ENSMUST00000077523.3
ENSMUST00000041388.4
Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 21.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.6 4.9 GO:0097212 lysosomal membrane organization(GO:0097212)
1.6 11.0 GO:0019532 oxalate transport(GO:0019532)
0.9 2.7 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.7 2.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.6 2.9 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.5 1.6 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.4 1.3 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.3 1.0 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.3 1.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 1.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.3 1.9 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.3 0.9 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.2 0.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 0.9 GO:0061743 motor learning(GO:0061743)
0.2 2.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 2.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.4 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.3 GO:0045575 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.1 0.9 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 0.8 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.4 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.4 GO:0015822 ornithine transport(GO:0015822)
0.1 0.2 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.4 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.1 0.8 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 1.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.6 GO:0048199 protein localization to pre-autophagosomal structure(GO:0034497) vesicle targeting, to, from or within Golgi(GO:0048199)
0.0 3.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.4 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 2.6 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.3 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.4 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.7 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 1.1 GO:0051693 actin filament capping(GO:0051693)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:1903977 positive regulation of Schwann cell migration(GO:1900149) positive regulation of glial cell migration(GO:1903977)
0.0 0.4 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.1 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.2 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.1 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.3 GO:0006907 pinocytosis(GO:0006907)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.2 2.7 GO:0016600 flotillin complex(GO:0016600)
0.1 0.5 GO:0008623 CHRAC(GO:0008623)
0.1 32.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 0.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.9 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 3.0 GO:0016459 myosin complex(GO:0016459)
0.1 0.2 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 2.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 4.8 GO:0070382 exocytic vesicle(GO:0070382)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 2.0 GO:0000792 heterochromatin(GO:0000792)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 21.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.0 11.0 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.7 4.8 GO:0001849 complement component C1q binding(GO:0001849)
0.3 1.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 2.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 3.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.4 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 0.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.4 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 1.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.2 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.5 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.1 0.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.1 0.9 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.4 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.4 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.8 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.8 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 3.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.0 GO:0005118 sevenless binding(GO:0005118)
0.0 0.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.1 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0 0.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.8 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 3.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 2.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 20.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 11.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 0.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 3.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)