Motif ID: Gsx2_Hoxd3_Vax1

Z-value: 0.630

Transcription factors associated with Gsx2_Hoxd3_Vax1:

Gene SymbolEntrez IDGene Name
Gsx2 ENSMUSG00000035946.6 Gsx2
Hoxd3 ENSMUSG00000079277.3 Hoxd3
Vax1 ENSMUSG00000006270.6 Vax1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx2mm10_v2_chr5_+_75075464_750756010.731.9e-10Click!
Vax1mm10_v2_chr19_-_59170978_591709780.696.1e-09Click!


Activity profile for motif Gsx2_Hoxd3_Vax1.

activity profile for motif Gsx2_Hoxd3_Vax1


Sorted Z-values histogram for motif Gsx2_Hoxd3_Vax1

Sorted Z-values for motif Gsx2_Hoxd3_Vax1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Top targets:


Showing 1 to 20 of 131 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710734 11.488 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 10.312 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_14621805 4.871 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr8_+_94152607 4.859 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr4_-_14621494 3.103 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 3.003 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr15_+_25773985 2.991 ENSMUST00000125667.1
 Myo10
myosin X
chr3_+_66219909 2.937 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr2_+_91457501 2.704 ENSMUST00000028689.3
 Lrp4
low density lipoprotein receptor-related protein 4
chr9_-_90255927 2.577 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr2_+_116067213 2.561 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr18_+_56432116 2.248 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr2_+_109917639 2.082 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr18_+_57142782 1.858 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr15_+_98571004 1.743 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr3_+_159839729 1.601 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr14_-_48662740 1.382 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr9_+_119063429 1.354 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr6_-_34317442 1.323 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr2_+_20737306 1.240 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.4 21.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.6 11.0 GO:0019532 oxalate transport(GO:0019532)
1.6 4.9 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 3.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.6 2.9 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.9 2.7 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 2.6 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 2.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.7 2.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 2.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 1.9 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.5 1.6 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.3 1.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.4 1.3 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.0 1.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.1 GO:0051693 actin filament capping(GO:0051693)
0.3 1.0 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.3 1.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 1.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.3 0.9 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 32.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.8 GO:0070382 exocytic vesicle(GO:0070382)
0.1 3.0 GO:0016459 myosin complex(GO:0016459)
0.2 2.7 GO:0016600 flotillin complex(GO:0016600)
0.0 2.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.0 GO:0000792 heterochromatin(GO:0000792)
0.1 1.9 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 1.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.5 GO:0008623 CHRAC(GO:0008623)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.2 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 21.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.0 11.0 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.7 4.8 GO:0001849 complement component C1q binding(GO:0001849)
0.1 3.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 3.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.2 2.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.3 1.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 1.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.9 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.8 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.8 GO:0070410 co-SMAD binding(GO:0070410)
0.1 0.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 3.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.8 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 11.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels